Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells

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dc.contributorLab. Bacteriologiapt_BR
dc.contributorLab. Parasitologiapt_BR
dc.contributorLab. Biotecnologia Viralpt_BR
dc.contributorCentro Bioindustrialpt_BR
dc.contributor.authorCaires-Júnior, Luiz Carlospt_BR
dc.contributor.authorGoulart, Ernestopt_BR
dc.contributor.authorMelo, Uirá Soutopt_BR
dc.contributor.authorAraujo, Bruno Henrique Silvapt_BR
dc.contributor.authorAlvizi, Lucaspt_BR
dc.contributor.authorSchanoski, Alessandra Soarespt_BR
dc.contributor.authorOliveira, Danyllo Felipe dept_BR
dc.contributor.authorKobayashi, Gerson Shigerupt_BR
dc.contributor.authorGriesi-Oliveira, Karinapt_BR
dc.contributor.authorMusso, Camila Mansopt_BR
dc.contributor.authorAmaral, Murilo Senapt_BR
dc.contributor.authorSilva, Lucas Ferreira dapt_BR
dc.contributor.authorAstray, Renato Mancinipt_BR
dc.contributor.authorSuarez-Patino, Sandra Fernandapt_BR
dc.contributor.authorVentini, Daniella Cristinapt_BR
dc.contributor.authorda Silva, Sergio Gomespt_BR
dc.contributor.authorYamamoto, Guilherme Lopespt_BR
dc.contributor.authorEzquina, Suzanapt_BR
dc.contributor.authorNaslavsky, Michel Satyapt_BR
dc.contributor.authorTelles-Silva, Kayque Alvespt_BR
dc.contributor.authorWeinmann, Karinapt_BR
dc.contributor.authorVan der Linden, Vanessapt_BR
dc.contributor.authorVan der Linden, Heliopt_BR
dc.contributor.authorMendes de Oliveira, Joao Ricardopt_BR
dc.contributor.authorRodrigues Arrais, Nivia Mariapt_BR
dc.contributor.authorMelo, Adrianapt_BR
dc.contributor.authorFigueiredo, Thalitapt_BR
dc.contributor.authorSantos, Silvanapt_BR
dc.contributor.authorCastro Meira, Joanna Goespt_BR
dc.contributor.authorPassos, Saulo Duartept_BR
dc.contributor.authorde Almeida, Roque Pachecopt_BR
dc.contributor.authorBispo, Ana Jovina Barretopt_BR
dc.contributor.authorCavalheiro, Esper Abraopt_BR
dc.contributor.authorKalil, Jorgept_BR
dc.contributor.authorCunha-Neto, Edeciopt_BR
dc.contributor.authorNakaya, Helderpt_BR
dc.contributor.authorSantos, Robert Andreatapt_BR
dc.contributor.authorFerreira, Luís Carlos de Souzapt_BR
dc.contributor.authorVerjovski-Almeida, Sergiopt_BR
dc.contributor.authorHo, Paulo Leept_BR
dc.contributor.authorPassos-Bueno, Maria Ritapt_BR
dc.contributor.authorZatz, Mayanapt_BR
dc.date.accessioned2020-07-09T21:19:29Z-
dc.date.available2020-07-09T21:19:29Z-
dc.date.issued2018pt_BR
dc.identifier.citationCaires-Júnior LC, Goulart E, Melo US, Araujo BHS, Alvizi L, Schanoski AS, et al. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat. Commun.. 2018 Feb;9:475. doi:10.1038/s41467-017-02790-9.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2422-
dc.description.abstractCongenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the NPCs from CZS babies show a significantly different gene expression signature of mTOR and Wnt pathway regulators, key to a neurodevelopmental program. Following ZIKV in vitro infection, cells from affected individuals have significantly higher ZIKV replication and reduced cell growth. Whole-exome analysis in 18 affected CZS babies as compared to 5 unaffected twins and 609 controls excludes a monogenic model to explain resistance or increased susceptibility to CZS development. Overall, our results indicate that CZS is not a stochastic event and depends on NPC intrinsic susceptibility, possibly related to oligogenic and/or epigenetic mechanisms.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extent475pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofNature Communicationspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleDiscordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cellspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1038/s41467-017-02790-9pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1038/s41467-017-02790-9pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalLaboratório Nacional de Biociências (LNBio)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)¦¦Brasilpt_BR
dc.contributor.externalHospital Israelita Albert Einstein¦¦Brasilpt_BR
dc.contributor.externalUniversidade de Mogi das Cruzes (UMC)¦¦Brasilpt_BR
dc.contributor.externalAssociação de Assistência à Criança Deficiente (AACD)¦¦Brasilpt_BR
dc.contributor.externalCentro de Reabilitação e Readaptação Dr Henrique Santillo (CRER)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal de Pernambuco (UFPE)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal do Rio Grande do Norte (UFRN)¦¦Brasilpt_BR
dc.contributor.externalInstituto de Saúde Elpídio de Almeida (ISEA)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Estadual da Paraíba (UEPB)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal da Bahia (UFBA)¦¦Brasilpt_BR
dc.contributor.externalFaculdade de Medicina de Jundiaí (FMJ)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal de Sergipe (UFS)¦¦Brasilpt_BR
dc.identifier.citationvolume9pt_BR
dc.relation.ispartofabbreviatedNat Communpt_BR
dc.identifier.citationabntv. 9, 475, fev. 2018pt_BR
dc.identifier.citationvancouver2018 Feb;9:475pt_BR
dc.contributor.butantanSchanoski, Alessandra Soares|:Pesquisador|:Lab. Bacteriologia|:pt_BR
dc.contributor.butantanAmaral, Murilo Sena|:Técnico|:Lab. Parasitologia|:pt_BR
dc.contributor.butantanAstray, Renato Mancini|:Pesquisador|:Lab. Biotecnologia Viral|:pt_BR
dc.contributor.butantanSuarez-Patino, Sandra Fernanda|:Aluno|:|:pt_BR
dc.contributor.butantanVentini, Daniella Cristina|:Técnico|:Centro Bioindustrialpt_BR
dc.contributor.butantanVerjovski-Almeida, Sergio|:Pesquisador|:Lab. Parasitologia|:pt_BR
dc.contributor.butantanHo, Paulo Lee|:Pesquisador|:Centro Bioindustrial|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦465355/2014-5pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦440770/2016-5pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/08028-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦14/50931-3pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/03620-2pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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