Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells

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dc.contributorLab. Bacteriologiapt_BR
dc.contributorLab. Parasitologiapt_BR
dc.contributor(LABV) Laboratório de Biotecnologia Viralpt_BR
dc.contributorCentro Bioindustrialpt_BR
dc.contributor(LMP) Laboratório Multipropósitopt_BR
dc.contributor.authorCaires-Júnior, Luiz Carlospt_BR
dc.contributor.authorGoulart, Ernestopt_BR
dc.contributor.authorMelo, Uirá Soutopt_BR
dc.contributor.authorAraujo, Bruno Henrique Silvapt_BR
dc.contributor.authorAlvizi, Lucaspt_BR
dc.contributor.authorSchanoski, Alessandra Soarespt_BR
dc.contributor.authorOliveira, Danyllo Felipe dept_BR
dc.contributor.authorKobayashi, Gerson Shigerupt_BR
dc.contributor.authorGriesi-Oliveira, Karinapt_BR
dc.contributor.authorMusso, Camila Mansopt_BR
dc.contributor.authorAmaral, Murilo Senapt_BR
dc.contributor.authorSilva, Lucas Ferreira dapt_BR
dc.contributor.authorAstray, Renato Mancinipt_BR
dc.contributor.authorSuarez-Patino, Sandra Fernandapt_BR
dc.contributor.authorVentini, Daniella Cristinapt_BR
dc.contributor.authorda Silva, Sergio Gomespt_BR
dc.contributor.authorYamamoto, Guilherme Lopespt_BR
dc.contributor.authorEzquina, Suzanapt_BR
dc.contributor.authorNaslavsky, Michel Satyapt_BR
dc.contributor.authorTelles-Silva, Kayque Alvespt_BR
dc.contributor.authorWeinmann, Karinapt_BR
dc.contributor.authorVan der Linden, Vanessapt_BR
dc.contributor.authorVan der Linden, Heliopt_BR
dc.contributor.authorMendes de Oliveira, Joao Ricardopt_BR
dc.contributor.authorRodrigues Arrais, Nivia Mariapt_BR
dc.contributor.authorMelo, Adrianapt_BR
dc.contributor.authorFigueiredo, Thalitapt_BR
dc.contributor.authorSantos, Silvanapt_BR
dc.contributor.authorCastro Meira, Joanna Goespt_BR
dc.contributor.authorPassos, Saulo Duartept_BR
dc.contributor.authorde Almeida, Roque Pachecopt_BR
dc.contributor.authorBispo, Ana Jovina Barretopt_BR
dc.contributor.authorCavalheiro, Esper Abraopt_BR
dc.contributor.authorKalil, Jorgept_BR
dc.contributor.authorCunha-Neto, Edeciopt_BR
dc.contributor.authorNakaya, Helderpt_BR
dc.contributor.authorSantos, Robert Andreatapt_BR
dc.contributor.authorFerreira, Luís Carlos de Souzapt_BR
dc.contributor.authorVerjovski-Almeida, Sergiopt_BR
dc.contributor.authorHo, Paulo Leept_BR
dc.contributor.authorPassos-Bueno, Maria Ritapt_BR
dc.contributor.authorZatz, Mayanapt_BR
dc.date.accessioned2020-07-09T21:19:29Z-
dc.date.available2020-07-09T21:19:29Z-
dc.date.issued2018pt_BR
dc.identifier.citationCaires-Júnior LC, Goulart E, Melo US, Araujo BHS, Alvizi L, Schanoski AS, et al. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nat. Commun.. 2018 Feb;9:475. doi:10.1038/s41467-017-02790-9.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2422-
dc.description.abstractCongenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the NPCs from CZS babies show a significantly different gene expression signature of mTOR and Wnt pathway regulators, key to a neurodevelopmental program. Following ZIKV in vitro infection, cells from affected individuals have significantly higher ZIKV replication and reduced cell growth. Whole-exome analysis in 18 affected CZS babies as compared to 5 unaffected twins and 609 controls excludes a monogenic model to explain resistance or increased susceptibility to CZS development. Overall, our results indicate that CZS is not a stochastic event and depends on NPC intrinsic susceptibility, possibly related to oligogenic and/or epigenetic mechanisms.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.extent475pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofNature Communicationspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleDiscordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cellspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1038/s41467-017-02790-9pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1038/s41467-017-02790-9pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(LNBio) Laboratório Nacional de Biociênciaspt_BR
dc.contributor.external(UNIFESP) Universidade Federal de São Paulopt_BR
dc.contributor.externalHospital Israelita Albert Einsteinpt_BR
dc.contributor.external(UMC) Universidade de Mogi das Cruzespt_BR
dc.contributor.external(AACD) Associação de Assistência à Criança Deficientept_BR
dc.contributor.external(CRER) Centro de Reabilitação e Readaptação Dr Henrique Santillopt_BR
dc.contributor.external(UFPE) Universidade Federal de Pernambucopt_BR
dc.contributor.external(UFRN) Universidade Federal do Rio Grande do Nortept_BR
dc.contributor.external(ISEA) Instituto de Saúde Elpídio de Almeidapt_BR
dc.contributor.external(UEPB) Universidade Estadual da Paraíbapt_BR
dc.contributor.external(UFBA) Universidade Federal da Bahiapt_BR
dc.contributor.external(FMJ) Faculdade de Medicina de Jundiaípt_BR
dc.contributor.external(UFS) Universidade Federal de Sergipept_BR
dc.identifier.citationvolume9pt_BR
dc.relation.ispartofabbreviatedNat Communpt_BR
dc.identifier.citationabntv. 9, 475, fev. 2018pt_BR
dc.identifier.citationvancouver2018 Feb;9:475pt_BR
dc.contributor.butantanSchanoski, Alessandra Soares|:Pesquisador|:Lab. Bacteriologia|:pt_BR
dc.contributor.butantanAmaral, Murilo Sena|:Técnico|:Lab. Parasitologia|:pt_BR
dc.contributor.butantanAstray, Renato Mancini|:Pesquisador|:Lab. Biotecnologia Viral|:pt_BR
dc.contributor.butantanSuarez-Patino, Sandra Fernanda|:Aluno|:|:pt_BR
dc.contributor.butantanVentini, Daniella Cristina|:Técnico|:Centro Bioindustrialpt_BR
dc.contributor.butantanVerjovski-Almeida, Sergio|:Pesquisador|:Lab. Parasitologia|:pt_BR
dc.contributor.butantanHo, Paulo Lee|:Pesquisador|:Centro Bioindustrial|:pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦465355/2014-5pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦440770/2016-5pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2013/08028-1pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦14/50931-3pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2014/03620-2pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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