Exercise increases insulin sensitivity and skeletal muscle AMPK expression in systemic lupus erythematosus: a randomized controlled trial

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dc.contributorLEDS - Laboratório de Dor e Sinalizaçãopt_BR
dc.contributor.authorBenatti, Fabiana B.pt_BR
dc.contributor.authorMiyake, Cintia N. H.pt_BR
dc.contributor.authorDantas, Wagner S.pt_BR
dc.contributor.authorZambelli, Vanessa Olzonpt_BR
dc.contributor.authorShinjo, Samuel K.pt_BR
dc.contributor.authorPereira, Rosa M. R.pt_BR
dc.contributor.authorSilva, Maria Elizabeth R.pt_BR
dc.contributor.authorSa-Pinto, Ana Luciapt_BR
dc.contributor.authorBorba, Eduardopt_BR
dc.contributor.authorBonfa, Eloisapt_BR
dc.contributor.authorGualano, Brunopt_BR
dc.date.accessioned2020-07-09T21:19:53Z-
dc.date.available2020-07-09T21:19:53Z-
dc.date.issued2018pt_BR
dc.identifier.citationBenatti FB., Miyake CN.H., Dantas WS., Zambelli VO, Shinjo SK., Pereira RM.R., et al. Exercise increases insulin sensitivity and skeletal muscle AMPK expression in systemic lupus erythematosus: a randomized controlled trial. Front. Immunol.. 2018 Apr;9:906. doi:10.3389/fimmu.2018.00906.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2454-
dc.description.abstractSystemic lupus erythematosus (SLE) patients may show increased insulin resistance (IR) when compared with their healthy peers. Exercise training has been shown to improve insulin sensitivity in other insulin-resistant populations, but it has never been tested in SLE. Therefore, the aim of the present study was to assess the efficacy of a moderate-intensity exercise training program on insulin sensitivity and potential underlying mechanisms in SLE patients with mild/inactive disease. A 12-week, randomized controlled trial was conducted. Nineteen SLE patients were randomly assigned into two groups: trained (SLE-TR, n = 9) and non-trained (SLE-NT, n = 10). Before and after 12 weeks of the exercise training program, patients underwent a meal test (MT), from which surrogates of insulin sensitivity and beta-cell function were determined. Muscle biopsies were performed after the MT for the assessment of total and membrane GLUT4 and proteins related to insulin signaling [ Akt and AMP-activated protein kinase (AMPK)]. SLE-TR showed, when compared with SLE-NT, significant decreases in fasting insulin [-39 vs. + 14%, p = 0.009, effect size (ES) = -1.0] and in the insulin response to MT (-23 vs. + 21%, p = 0.007, ES = -1.1), homeostasis model assessment IR (-30 vs. + 15%, p = 0.005, ES = -1.1), a tendency toward decreased proinsulin response to MT (-19 vs. + 6%, p = 0.07, ES = -0.9) and increased glucagon response to MT (+3 vs. -3%, p = 0.09, ES = 0.6), and significant increases in the Matsuda index (+66 vs. -31%, p = 0.004, ES = 0.9) and fasting glucagon (+4 vs. -8%, p = 0.03, ES = 0.7). No significant differences between SLT-TR and SLT-NT were observed in fasting glucose, glucose response to MT, and insulinogenic index (all p > 0.05). SLE-TR showed a significant increase in AMPK Thr 172 phosphorylation when compared to SLE-NT (+73 vs. -12%, p = 0.014, ES = 1.3), whereas no significant differences between groups were observed in Akt Ser 473 phosphorylation, total and membrane GLUT4 expression, and GLUT4 translocation (all p > 0.05). In conclusion, a 12-week moderate-intensity aerobic exercise training program improved insulin sensitivity in SLE patients with mild/inactive disease. This effect appears to be partially mediated by the increased insulin-stimulated skeletal muscle AMPK phosphorylation.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent906pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofFrontiers in Immunologypt_BR
dc.rightsOpen Accesspt_BR
dc.titleExercise increases insulin sensitivity and skeletal muscle AMPK expression in systemic lupus erythematosus: a randomized controlled trialpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3389/fimmu.2018.00906pt_BR
dc.identifier.urlhttps://doi.org/10.3389/fimmu.2018.00906pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Estadual de Campinas (UNICAMP)¦¦Brasilpt_BR
dc.identifier.citationvolume9pt_BR
dc.subject.keywordaerobic exercisept_BR
dc.subject.keywordinsulin resistancept_BR
dc.subject.keywordglucagonpt_BR
dc.subject.keywordGLUT4pt_BR
dc.subject.keywordinflammatory rheumatic diseasept_BR
dc.relation.ispartofabbreviatedFront Immunolpt_BR
dc.identifier.citationabntv. 9, 906, abr. 2018pt_BR
dc.identifier.citationvancouver2018 Apr;9:906pt_BR
dc.contributor.butantanZambelli, Vanessa Olzon|:Pesquisador:Docente Permanente PPGTOX|:LEDS - Laboratório de Dor e Sinalização|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦150737/2015-7pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦305068/2014-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/24093-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/08302-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/03756-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/02546-1pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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