Beta-defensin genes of the Colubridae snakes Phalotris mertensi, Thamnodynastes hypoconia, and T. strigatus
beta-Defensins are cationic antimicrobial peptides showing little sequence similarity but highly conserved tertiary structure stabilized by a six-cysteines-motif. Using a PCR approach, we described beta-defensin sequences with two exons in three species of Colubridae snakes with high sequence similarity between them. The deduced amino acid sequence presented the characteristics of beta-defensin family. The phylogenetic analysis using beta-defensin coding sequences of different snakes grouped them in two main branches: genes organized in three or two exons.
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Keywords
Antimicrobial peptides; Colubrid snakes; ß-defensin genes
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Oliveira YS, Corrêa PG, Oguiura N. Beta-defensin genes of the Colubridae snakes Phalotris mertensi, Thamnodynastes hypoconia, and T. strigatus. Toxicon. 2018 May;146:124-8. doi:10.1016/j.toxicon.2018.02.048.
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