Biological effects and biodistribution of bufotenine on mice

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dc.contributorLab. Bioquímicapt_BR
dc.contributorLab. Biologia Molecularpt_BR
dc.contributorLaboratório de Toxinologia Aplicadapt_BR
dc.contributorLab. Biologia Estruturalpt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorVigerelli, Hugopt_BR
dc.contributor.authorSciani, Juliana Mozerpt_BR
dc.contributor.authorCamarano, María Andrea Eulapt_BR
dc.contributor.authorSato, Luciana Almeidapt_BR
dc.contributor.authorAntoniazzi, Marta Mariapt_BR
dc.contributor.authorJared, Carlospt_BR
dc.contributor.authorPimenta, Daniel Carvalhopt_BR
dc.date.accessioned2020-07-09T21:20:06Z-
dc.date.available2020-07-09T21:20:06Z-
dc.date.issued2018pt_BR
dc.identifier.citationVigerelli H, Sciani JM, Camarano MAE, Sato LA, Antoniazzi MM, Jared C, et al. Biological effects and biodistribution of bufotenine on mice. Biomed Res. Int.. 2018;2018:1032638. doi:10.1155/2018/1032638.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2469-
dc.description.abstractBufotenine is an alkaloid derived fromserotonin, structurally similar to LSD and psilocin. Thismolecule is able to inhibit the rabies virus infection in in vitro and in vivo models, increasing the survival rate of infected animals. Being a very promising molecule for an incurable disease and because of the fact that there is no consensus regarding its neurological effects, this study aimed to evaluate chronic treatment of bufotenine on behavior, pathophysiology, and pharmacokinetics of mice. Animals were daily treated for 21 consecutive days with 0.63, 1.05, and 2.1 mg/animal/day bufotenine and evaluated by open field test and physiological parameters during all the experiment. After this period, organs were collected for histopathological and biodistribution analysis. Animals treated with bufotenine had mild behavioral alterations compared to the control group, being dose-response relationship. On the other hand, animals showed normal physiological functions and no histological alterations in the organs. With high doses, an inflammatory reaction was observed in the site of injection, but with no cellular damage. The alkaloid could be found in the heart and kidney with all doses and in the lungs and brain with higher doses. These results show that the effective dose, 0.63 mg/day, is safe to be administered in mice, since it did not cause significant effects on the animals' physiology and on the CNS. Higher doses were well tolerated, causing only mild behavioral effects. Thus, bufotenine might be a drug prototype for rabies treatment, an incurable disease.pt_BR
dc.format.extent1032638pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofBioMed Research Internationalpt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleBiological effects and biodistribution of bufotenine on micept_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.1155/2018/1032638pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1155/2018/1032638pt_BR
dc.identifier.citationvolume2018pt_BR
dc.relation.ispartofabbreviatedBiomed Res Intpt_BR
dc.identifier.citationabntv. 2018, 1032638, 2018pt_BR
dc.identifier.citationvancouver2018;2018:1032638pt_BR
dc.contributor.butantanSciani, Juliana Mozer|:Técnico:Docente Colaborador PPGTOX|:Lab. Biologia Molecular|:Autor de correspondênciapt_BR
dc.contributor.butantanSato, Luciana Almeida|:Técnico:Aluno|:Lab. Biologia Estrutural:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:pt_BR
dc.contributor.butantanAntoniazzi, Marta Maria|:Pesquisador:Docente Permanente PPGTOX|:Lab. Biologia Estrutural|:pt_BR
dc.contributor.butantanJared, Carlos|:Pesquisador:Docente Permanente PPGTOX|:Lab. Biologia Estrutural|:pt_BR
dc.contributor.butantanPimenta, Daniel Carvalho|:Pesquisador:Docente Permanente PPGTOX|:Lab. Bioquímica|:pt_BR
dc.contributor.butantanCamarano, María Andrea Eula|:Aluno|:Laboratório de Toxinologia Aplicada:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:pt_BR
dc.contributor.butantanVigerelli, Hugo|:Aluno Egresso|:Lab. Bioquímica:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:PrimeiroAutorpt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
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