
Biological effects and biodistribution of bufotenine on mice
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DC Field | Value | Language |
---|---|---|
dc.contributor | Lab. Bioquímica | pt_BR |
dc.contributor | (LDI) Laboratório de Desenvolvimento e Inovação Industrial | pt_BR |
dc.contributor | Laboratório de Toxinologia Aplicada | pt_BR |
dc.contributor | Lab. Biologia Estrutural | pt_BR |
dc.contributor | Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox) | pt_BR |
dc.contributor.author | Vigerelli, Hugo | pt_BR |
dc.contributor.author | Sciani, Juliana Mozer | pt_BR |
dc.contributor.author | Camarano, María Andrea Eula | pt_BR |
dc.contributor.author | Sato, Luciana Almeida | pt_BR |
dc.contributor.author | Antoniazzi, Marta Maria | pt_BR |
dc.contributor.author | Jared, Carlos | pt_BR |
dc.contributor.author | Pimenta, Daniel Carvalho | pt_BR |
dc.date.accessioned | 2020-07-09T21:20:06Z | - |
dc.date.available | 2020-07-09T21:20:06Z | - |
dc.date.issued | 2018 | pt_BR |
dc.identifier.citation | Vigerelli H, Sciani JM, Camarano MAE, Sato LA, Antoniazzi MM, Jared C, et al. Biological effects and biodistribution of bufotenine on mice. Biomed Res. Int.. 2018;2018:1032638. doi:10.1155/2018/1032638. | pt_BR |
dc.identifier.uri | https://repositorio.butantan.gov.br/handle/butantan/2469 | - |
dc.description.abstract | Bufotenine is an alkaloid derived fromserotonin, structurally similar to LSD and psilocin. Thismolecule is able to inhibit the rabies virus infection in in vitro and in vivo models, increasing the survival rate of infected animals. Being a very promising molecule for an incurable disease and because of the fact that there is no consensus regarding its neurological effects, this study aimed to evaluate chronic treatment of bufotenine on behavior, pathophysiology, and pharmacokinetics of mice. Animals were daily treated for 21 consecutive days with 0.63, 1.05, and 2.1 mg/animal/day bufotenine and evaluated by open field test and physiological parameters during all the experiment. After this period, organs were collected for histopathological and biodistribution analysis. Animals treated with bufotenine had mild behavioral alterations compared to the control group, being dose-response relationship. On the other hand, animals showed normal physiological functions and no histological alterations in the organs. With high doses, an inflammatory reaction was observed in the site of injection, but with no cellular damage. The alkaloid could be found in the heart and kidney with all doses and in the lungs and brain with higher doses. These results show that the effective dose, 0.63 mg/day, is safe to be administered in mice, since it did not cause significant effects on the animals' physiology and on the CNS. Higher doses were well tolerated, causing only mild behavioral effects. Thus, bufotenine might be a drug prototype for rabies treatment, an incurable disease. | pt_BR |
dc.format.extent | 1032638 | pt_BR |
dc.language.iso | English | pt_BR |
dc.relation.ispartof | BioMed Research International | pt_BR |
dc.rights | Open access | pt_BR |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | pt_BR |
dc.title | Biological effects and biodistribution of bufotenine on mice | pt_BR |
dc.type | Article | pt_BR |
dc.rights.license | CC BY | pt_BR |
dc.identifier.doi | 10.1155/2018/1032638 | pt_BR |
dc.identifier.url | http://dx.doi.org/10.1155/2018/1032638 | pt_BR |
dc.identifier.citationvolume | 2018 | pt_BR |
dc.relation.ispartofabbreviated | Biomed Res Int | pt_BR |
dc.identifier.citationabnt | v. 2018, 1032638, 2018 | pt_BR |
dc.identifier.citationvancouver | 2018;2018:1032638 | pt_BR |
dc.contributor.butantan | Sciani, Juliana Mozer|:Técnico:Docente Colaborador PPGTOX|:Lab. Biologia Molecular|:Autor de correspondência | pt_BR |
dc.contributor.butantan | Sato, Luciana Almeida|:Técnico:Aluno|:Lab. Biologia Estrutural:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|: | pt_BR |
dc.contributor.butantan | Antoniazzi, Marta Maria|:Pesquisador:Docente Permanente PPGTOX|:Lab. Biologia Estrutural|: | pt_BR |
dc.contributor.butantan | Jared, Carlos|:Pesquisador:Docente Permanente PPGTOX|:Lab. Biologia Estrutural|: | pt_BR |
dc.contributor.butantan | Pimenta, Daniel Carvalho|:Pesquisador:Docente Permanente PPGTOX|:Lab. Bioquímica|: | pt_BR |
dc.contributor.butantan | Camarano, María Andrea Eula|:Aluno|:Laboratório de Toxinologia Aplicada:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|: | pt_BR |
dc.contributor.butantan | Vigerelli, Hugo|:Aluno Egresso|:Lab. Bioquímica:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:PrimeiroAutor | pt_BR |
dc.identifier.bvscc | BR78.1 | pt_BR |
dc.identifier.bvsdb | IBProd | pt_BR |
dc.description.dbindexed | Yes | pt_BR |
item.fulltext | Com Texto completo | - |
item.openairetype | Article | - |
item.languageiso639-1 | English | - |
item.grantfulltext | open | - |
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crisitem.author.dept | #PLACEHOLDER_PARENT_METADATA_VALUE# | - |
crisitem.author.orcid | 0000-0002-8197-2260 | - |
crisitem.author.orcid | 0000-0001-7213-206X | - |
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crisitem.author.orcid | 0000-0002-0575-7921 | - |
crisitem.author.orcid | 0000-0002-9117-6276 | - |
crisitem.author.orcid | 0000-0003-2406-0860 | - |
crisitem.journal.journalissn | #PLACEHOLDER_PARENT_METADATA_VALUE# | - |
crisitem.journal.journaleissn | #PLACEHOLDER_PARENT_METADATA_VALUE# | - |
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