Germline control of somatic Kras mutations in mouse lung tumors

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dc.contributorLab. Imunogenéticapt_BR
dc.contributor.authorBorrego, Andreapt_BR
dc.contributor.authorCabrera, Wafa Hanna Kourypt_BR
dc.contributor.authorJensen, José Ricardopt_BR
dc.contributor.authorCorrêa, Mara Adrianapt_BR
dc.contributor.authorRibeiro, Orlando Garciapt_BR
dc.contributor.authorStarobinas, Nancypt_BR
dc.contributor.authorDe Franco, Marcelopt_BR
dc.contributor.authorPettinicchio, Angelapt_BR
dc.contributor.authorDragani, Tommaso A.pt_BR
dc.contributor.authorIbañez, Olga Célia Martinezpt_BR
dc.contributor.authorManenti, Giacomopt_BR
dc.identifier.citationBorrego A, Cabrera WHK, Jensen JR, Corrêa MA, Ribeiro OG, Starobinas N, et al. Germline control of somatic Kras mutations in mouse lung tumors. Mol. Carcinog.. 2018 Jun;57(6):745-51. doi:10.1002/mc.22796.pt_BR
dc.description.abstractSomatic KRAS mutations are common in human lung adenocarcinomas and are associated with worse prognosis. In mice, Kras is frequently mutated in both spontaneous and experimentally induced lung tumors, although the pattern of mutation varies among strains, suggesting that such mutations are not random events. We tested if the occurrence of Kras mutations is under genetic control in two mouse intercrosses. Codon 61 mutations were prevalent, but the patterns of nucleotide changes differed between the intercrosses. Whole genome analysis with SNPs in (A/J x C57BL/6)F4 mice revealed a significant linkage between a locus on chromosome 19 and 2 particular codon 61 variants (CTA and CGA). In (AIRmaxxAIRmin) F2 mice, there was a significant linkage between SNPs located on distal chromosome 6 (around 135Mbp) and the frequency of codon 61 mutation. These results reveal the presence of two loci, on chromosomes 6 and 19, that modulate Kras mutation frequency in different mouse intercrosses. These findings indicate that somatic mutation frequency and type are not simple random events, but are under genetic control.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipAssociazione italiana per la ricerca sul cancro (AIRC)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extentp. 745-51pt_BR
dc.relation.ispartofMolecular Carcinogenesispt_BR
dc.titleGermline control of somatic Kras mutations in mouse lung tumorspt_BR
dc.contributor.externalFondazione IRCCS Istituto Nazionale dei Tumori¦¦Itáliapt_BR
dc.subject.keywordgenome-wide association studypt_BR
dc.subject.keywordlung cancerpt_BR
dc.relation.ispartofabbreviatedMol Carcinogpt_BR
dc.identifier.citationabntv. 57, n. 6, p. 745-751, jun. 2018pt_BR
dc.identifier.citationvancouver2018 Jun;57(6):745-51pt_BR
dc.contributor.butantanCabrera, Wafa Hanna Koury|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanJensen, José Ricardo|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanCorrêa, Mara Adriana|:Aluno|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanRibeiro, Orlando Garcia|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanStarobinas, Nancy|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanDe Franco, Marcelo|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanIbañez, Olga Célia Martinez|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanBorrego, Andrea|:Pesquisador|:Lab. Imunogenética|:PrimeiroAutorpt_BR
dc.sponsorship.butantanAssociazione italiana per la ricerca sul cancro (AIRC)¦¦15797pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/21129-6pt_BR
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