Germline control of somatic Kras mutations in mouse lung tumors
Full metadata record
DC Field | Value | Language |
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dc.contributor | Laboratório de Imunogenética | pt_BR |
dc.contributor.author | Borrego, Andrea | pt_BR |
dc.contributor.author | Cabrera, Wafa Hanna Koury | pt_BR |
dc.contributor.author | Jensen, José Ricardo | pt_BR |
dc.contributor.author | Corrêa, Mara Adriana | pt_BR |
dc.contributor.author | Ribeiro, Orlando Garcia | pt_BR |
dc.contributor.author | Starobinas, Nancy | pt_BR |
dc.contributor.author | De Franco, Marcelo | pt_BR |
dc.contributor.author | Pettinicchio, Angela | pt_BR |
dc.contributor.author | Dragani, Tommaso A. | pt_BR |
dc.contributor.author | Ibañez, Olga Célia Martinez | pt_BR |
dc.contributor.author | Manenti, Giacomo | pt_BR |
dc.date.accessioned | 2020-07-09T21:20:40Z | - |
dc.date.available | 2020-07-09T21:20:40Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Borrego A, Cabrera WHK, Jensen JR, Corrêa MA, Ribeiro OG, Starobinas N, et al. Germline control of somatic Kras mutations in mouse lung tumors. Mol. Carcinog.. 2018 Jun;57(6):745-51. doi:10.1002/mc.22796. | pt_BR |
dc.identifier.issn | 0899-1987 | - |
dc.identifier.uri | https://repositorio.butantan.gov.br/handle/butantan/2509 | - |
dc.description.abstract | Somatic KRAS mutations are common in human lung adenocarcinomas and are associated with worse prognosis. In mice, Kras is frequently mutated in both spontaneous and experimentally induced lung tumors, although the pattern of mutation varies among strains, suggesting that such mutations are not random events. We tested if the occurrence of Kras mutations is under genetic control in two mouse intercrosses. Codon 61 mutations were prevalent, but the patterns of nucleotide changes differed between the intercrosses. Whole genome analysis with SNPs in (A/J x C57BL/6)F4 mice revealed a significant linkage between a locus on chromosome 19 and 2 particular codon 61 variants (CTA and CGA). In (AIRmaxxAIRmin) F2 mice, there was a significant linkage between SNPs located on distal chromosome 6 (around 135Mbp) and the frequency of codon 61 mutation. These results reveal the presence of two loci, on chromosomes 6 and 19, that modulate Kras mutation frequency in different mouse intercrosses. These findings indicate that somatic mutation frequency and type are not simple random events, but are under genetic control. | pt_BR |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | pt_BR |
dc.description.sponsorship | Associazione italiana per la ricerca sul cancro (AIRC) | pt_BR |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | pt_BR |
dc.format.extent | p. 745-51 | pt_BR |
dc.language | eng | pt_BR |
dc.publisher | Wiley | pt_BR |
dc.relation.ispartof | Molecular Carcinogenesis | pt_BR |
dc.title | Germline control of somatic Kras mutations in mouse lung tumors | pt_BR |
dc.type | Article | pt_BR |
dc.identifier.doi | 10.1002/mc.22796 | pt_BR |
dc.identifier.url | http://dx.doi.org/10.1002/mc.22796 | pt_BR |
dc.contributor.external | Fondazione IRCCS Istituto Nazionale dei Tumori¦¦Itália | pt_BR |
dc.publisher.city | Hoboken | pt_BR |
dc.identifier.citationvolume | 57 | pt_BR |
dc.identifier.citationissue | 6 | pt_BR |
dc.subject.keyword | genome-wide association study | pt_BR |
dc.subject.keyword | Kras | pt_BR |
dc.subject.keyword | lung cancer | pt_BR |
dc.subject.keyword | Pas1 | pt_BR |
dc.subject.keyword | polymorphisms | pt_BR |
dc.relation.ispartofabbreviated | Mol. Carcinog. | pt_BR |
dc.identifier.citationabnt | v. 57, n. 6, p. 745-751, jun. 2018 | pt_BR |
dc.identifier.citationvancouver | 2018 Jun;57(6):745-51 | pt_BR |
dc.publisher.country | United States | pt_BR |
dc.contributor.butantan | Cabrera, Wafa Hanna Koury|:Pesquisador|:Laboratório de Imunogenética|: | pt_BR |
dc.contributor.butantan | Jensen, José Ricardo|:Pesquisador|:Laboratório de Imunogenética|: | pt_BR |
dc.contributor.butantan | Corrêa, Mara Adriana|:Aluno|:Laboratório de Imunogenética|: | pt_BR |
dc.contributor.butantan | Ribeiro, Orlando Garcia|:Pesquisador|:Laboratório de Imunogenética|: | pt_BR |
dc.contributor.butantan | Starobinas, Nancy|:Pesquisador|:Laboratório de Imunogenética|: | pt_BR |
dc.contributor.butantan | De Franco, Marcelo|:Pesquisador|:Laboratório de Imunogenética|: | pt_BR |
dc.contributor.butantan | Ibañez, Olga Célia Martinez|:Pesquisador|:Laboratório de Imunogenética|: | pt_BR |
dc.contributor.butantan | Borrego, Andrea|:Pesquisador|:Laboratório de Imunogenética|:PrimeiroAutor | pt_BR |
dc.sponsorship.butantan | Associazione italiana per la ricerca sul cancro (AIRC)¦¦15797 | pt_BR |
dc.sponsorship.butantan | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦ | pt_BR |
dc.sponsorship.butantan | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/21129-6 | pt_BR |
dc.identifier.bvscc | BR78.1 | pt_BR |
dc.identifier.bvsdb | IBProd | pt_BR |
item.openairetype | Article | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | embargo_29990101 | - |
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