Predicting acute renal failure in Bothrops snakebite patients in a tertiary reference center, Western Brazilian Amazon

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dc.contributorLaboratório de Imunopatologiapt_BR
dc.contributorLaboratório de Artrópodespt_BR
dc.contributor.authorAlves, Eliane Campospt_BR
dc.contributor.authorSachett, Jacqueline de Almeida Gonçalvespt_BR
dc.contributor.authorSampaio, Vanderson Souzapt_BR
dc.contributor.authorSousa, José Diego de Britopt_BR
dc.contributor.authorOliveira, Sâmella Silva dept_BR
dc.contributor.authordo Nascimento, Elizandra Freitaspt_BR
dc.contributor.authorSantos, Alessandra dos Santospt_BR
dc.contributor.authorSilva, Iran Mendonça dapt_BR
dc.contributor.authorMoura-da-Silva, Ana Mariapt_BR
dc.contributor.authorFan, Hui Wenpt_BR
dc.contributor.authorColombini, Mônicapt_BR
dc.contributor.authorLacerda, Marcus Vinicius Guimarães dept_BR
dc.contributor.authorMonteiro, Wuelton Marcelopt_BR
dc.contributor.authorde Lima Ferreira, Luiz Carlospt_BR
dc.identifier.citationAlves EC, Sachett JAG, Sampaio VS, Sousa JDB, Oliveira SS, do Nascimento EF, et al. Predicting acute renal failure in Bothrops snakebite patients in a tertiary reference center, Western Brazilian Amazon. PLoS One. 2018 Aug;13(8):e0202361. doi:10.1371/journal.pone.0202361.pt_BR
dc.description.abstractAcute Kidney Injury (AKI) is the main systemic complication and cause of death in viperid envenomation. Although there are hypotheses for the development of AKI, the mechanisms involved are still not established. The aim of this study was to evaluate the clinical-laboratorial-epidemiological factors associated with AKI in victims of Bothrops sp envenomation. This is an observational study carried out at the Fundac¸ão de Medicina Tropical Dr. Heitor Vieira Dourado. AKI was defined according to the guidelines of the Acute Kidney Injury Network (AKIN). Among the 186 patients evaluated, AKI was observed in 24 (12.9%) after 48 hours of admission. Stage I was present in 17 (70.8%) patients, II in 3 (12.5%) and III in 4 (16.7%). Epidemiological characterization showed predominance of men, occurrence in rural areas, aged between 16–60 years, feet as the most affected anatomical region, and time to medical assistance less than 3 hours. Hypertension and diabetes were the comorbidities identified. Most of the accidents were classified as moderate, and clinical manifestations included severe pain, mild edema, local bleeding and headache. Laboratory results showed blood uncoagulability, hypofibrinogenemia, leukocytosis, increase of creatine kinase, and high lactate dehydrogenase levels. Multivariate analysis showed an association with high LDH levels [AOR = 1.01 (95% CI = 1.01–1.01, p<0.002)], local bleeding [AOR = 0.13 (95%CI = 0.027–0.59, p<0.009)], and the presence of comorbidities [AOR = 60.96 (95%CI = 9.69–383.30; p<0.000)]. Herein, laboratory markers such as high LDH levels along with local bleeding and comorbidities may aid in the diagnosis of AKI.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)pt_BR
dc.publisherPublic Library Sciencept_BR
dc.relation.ispartofPloS Onept_BR
dc.rightsOpen Accesspt_BR
dc.titlePredicting acute renal failure in Bothrops snakebite patients in a tertiary reference center, Western Brazilian Amazonpt_BR
dc.contributor.externalUniversidade do Estado do Amazonas (UEA)¦¦Brasilpt_BR
dc.contributor.externalFundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD)¦¦Brasilpt_BR
dc.contributor.externalFundação Vigilância em Saúde do Amazonas (FVS-AM)¦¦Brasilpt_BR
dc.contributor.externalInstituto Leônidas & Maria Deane (ILMD/Fiocruz Amazônia)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal do Amazonas (UFAM)¦¦Brasilpt_BR
dc.publisher.citySan Franciscopt_BR
dc.relation.ispartofabbreviatedPLoS Onept_BR
dc.identifier.citationabntv. 13, n. 8, e0202361, ago. 2018pt_BR
dc.identifier.citationvancouver2018 Aug;13(8):e0202361pt_BR
dc.publisher.countryUnited Statespt_BR
dc.contributor.butantanMoura-da-Silva, Ana Maria|:Docente Permanente PPGTOX|:Laboratório de Imunopatologia|:pt_BR
dc.contributor.butantanFan, Hui Wen|:Pesquisador|:Laboratório de Artrópodes|:pt_BR
dc.contributor.butantanColombini, Mônica|:Técnico|:Laboratório de Imunopatologia|:pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)¦¦287/2013pt_BR
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