Mice selected for acute inflammation present altered immune response during Pristane-induced arthritis progression

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dc.contributorLab. Imunogenéticapt_BR
dc.contributor.authorCorrêa, Mara Adrianapt_BR
dc.contributor.authorBorrego, Andreapt_BR
dc.contributor.authorJensen, José Ricardopt_BR
dc.contributor.authorCabrera, Wafa Hanna Kourypt_BR
dc.contributor.authorBarros, Michelept_BR
dc.contributor.authorKatz, Iana S. S.pt_BR
dc.contributor.authorCanhamero, Tatiane Aparecidapt_BR
dc.contributor.authorSpadafora-Ferreira, Mônicapt_BR
dc.contributor.authorFernandes, Jussara Gonçalvespt_BR
dc.contributor.authorStarobinas, Nancypt_BR
dc.contributor.authorRibeiro, Orlando Garciapt_BR
dc.contributor.authorIbañez, Olga Célia Martinezpt_BR
dc.contributor.authorDe Franco, Marcelopt_BR
dc.date.accessioned2020-07-09T21:21:56Z-
dc.date.available2020-07-09T21:21:56Z-
dc.date.issued2018pt_BR
dc.identifier.citationCorrêa MA, Borrego A, Jensen JR, Cabrera WHK, Barros M, Katz IS.S., et al. Mice selected for acute inflammation present altered immune response during Pristane-induced arthritis progression. Biomed Res. Int.. 2018;2018:1267038. doi:10.1155/2018/1267038.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2605-
dc.description.abstractMouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltration of lymphocytes, as well as monocytes/macrophages and neutrophils, producing higher levels of IL-1ß, IFN-?, TNF-a, IL-10, total IgG3, and chemokines. Resistant AIRmin mice controlled cell activation more efficiently than the AIRmax during arthritis progression. The weight alterations of the spleen and thymus in the course of PIA were observed. Our data suggest that selected AIRmax cellular and genetic immune mechanisms contribute to cartilage damage and arthritis severity, evidencing many targets for therapeutic actions.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent1267038pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofBioMed Research Internationalpt_BR
dc.rightsOpen Accesspt_BR
dc.titleMice selected for acute inflammation present altered immune response during Pristane-induced arthritis progressionpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1155/2018/1267038pt_BR
dc.identifier.urlhttps://doi.org/10.1155/2018/1267038pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalInstituto Pasteur¦¦Brasilpt_BR
dc.identifier.citationvolume2018pt_BR
dc.relation.ispartofabbreviatedBiomed Res Intpt_BR
dc.identifier.citationabntv. 2018, 1267038, 2018pt_BR
dc.identifier.citationvancouver2018;2018:1267038pt_BR
dc.contributor.butantanBorrego, Andrea|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanJensen, José Ricardo|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanCabrera, Wafa Hanna Koury|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanCanhamero, Tatiane Aparecida|:Aluno|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanSpadafora-Ferreira, Mônica|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanFernandes, Jussara Gonçalves|:Aluno|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanStarobinas, Nancy|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanRibeiro, Orlando Garcia|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanIbañez, Olga Célia Martinez|:Pesquisador|:Lab. Imunogenética|:pt_BR
dc.contributor.butantanDe Franco, Marcelo|:Pesquisador|:Lab. Imunogenética|:Autor de correspondênciapt_BR
dc.contributor.butantanCorrêa, Mara Adriana|:Aluno|:Lab. Imunogenética|:PrimeiroAutorpt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/18060-2pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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