Heparin-binding protein release is strongly induced by Leptospira species and is a candidate for an early diagnostic marker of human Leptospirosis

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dc.contributorLEDV - Laboratório de Desenvolvimento de Vacinaspt_BR
dc.contributorLETA - Laboratório de Toxinologia Aplicadapt_BR
dc.contributor.authorVieira, Mônica Laruccipt_BR
dc.contributor.authorPersson, Sandrapt_BR
dc.contributor.authorLopes-Ferreira, Monicapt_BR
dc.contributor.authorRomero, Eliete C.pt_BR
dc.contributor.authorKirchgatter, Karinpt_BR
dc.contributor.authorNascimento, Ana Lúcia Tabet Oller dopt_BR
dc.contributor.authorHerwald, Heikopt_BR
dc.date.accessioned2020-07-09T21:23:18Z-
dc.date.available2020-07-09T21:23:18Z-
dc.date.issued2019pt_BR
dc.identifier.citationVieira ML, Persson S, Lopes-Ferreira M, Romero EC., Kirchgatter K, Nascimento ALTO, et al. Heparin-binding protein release is strongly induced by Leptospira species and is a candidate for an early diagnostic marker of human Leptospirosis. J infect dis. 2019 Mar;219(6):996-1006. doi:10.1093/infdis/jiy589.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2698-
dc.description.abstractBackground Leptospirosis, caused by spirochetes of the genus Leptospira, is one of the most widespread zoonoses worldwide. Efficient diagnostic methods for early diagnosis of leptospirosis are still lacking, and acute disease presents with nonspecific symptomatology and is often misdiagnosed. The leptospires pathogenic processes and virulence mechanisms remain virtually unknown. In severe infections, hemostatic impairment is frequently observed, and pathophysiological complications often develop when the host response is modulated by the pathogen. The neutrophil heparin-binding protein (HBP) is an inflammatory mediator and potent inducer of vascular leakage. Results In this study, we found that leptospires and their secreted products induce the release of HBP from stimulated neutrophils through a controlled degranulation mechanism. We acknowledged 2 leptospiral proteins as able to induce HBP degranulation. These findings have clinical implications, as high levels of HBP were detected in serum from patients with leptospirosis, especially at the early phase of the disease. Conclusion In conclusion, we describe a new mechanism by which the leptospirosis pathophysiological complications may arise, such as vascular leakage and edema formation. We also propose HBP as a new early screening biomarker for human leptospirosis.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipAlfred Österlunds Stiftelsept_BR
dc.description.sponsorshipKnut and Alice Wallenberg Foundationpt_BR
dc.description.sponsorshipRagnar Söderbergs Stiftelsept_BR
dc.description.sponsorshipMedical Faculty of Lund Universitypt_BR
dc.description.sponsorshipSwedish Foundation for Strategic Research (SSF)pt_BR
dc.description.sponsorshipSwedish Research Councilpt_BR
dc.format.extentp. 996-1006pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofThe Journal of Infectious Diseasespt_BR
dc.titleHeparin-binding protein release is strongly induced by Leptospira species and is a candidate for an early diagnostic marker of human Leptospirosispt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1093/infdis/jiy589pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1093/infdis/jiy589pt_BR
dc.contributor.externalLunds Universitet¦¦Suéciapt_BR
dc.contributor.externalInstituto Adolfo Lutz (IAL)¦¦Brasilpt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume219pt_BR
dc.identifier.citationissue6pt_BR
dc.subject.keywordLeptospirapt_BR
dc.subject.keywordinflammationpt_BR
dc.subject.keywordinfectionpt_BR
dc.subject.keywordneutrophilspt_BR
dc.subject.keywordhost-pathogen-interactionspt_BR
dc.relation.ispartofabbreviatedJ infect dispt_BR
dc.identifier.citationabntv. 219, n. 6, p. 996-1006, mar. 2019pt_BR
dc.identifier.citationvancouver2019 Mar;219(6):996-1006pt_BR
dc.contributor.butantanVieira, Mônica Larucci|:Aluno|:LEDV - Laboratório de Desenvolvimento de Vacinas|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanLopes-Ferreira, Monica Valdyrce dos Anjos|:Pesquisador:Docente Permanente PPGTOX|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.contributor.butantanNascimento, Ana Lúcia Tabet Oller do|:Pesquisador|:LEDV - Laboratório de Desenvolvimento de Vacinas|:pt_BR
dc.sponsorship.butantanAlfred Österlunds Stiftelse¦¦pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦150520/2017-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/18337-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/07054-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/50981-0pt_BR
dc.sponsorship.butantanKnut and Alice Wallenberg Foundation¦¦pt_BR
dc.sponsorship.butantanMedical Faculty of Lund University¦¦pt_BR
dc.sponsorship.butantanRagnar Söderbergs Stiftelse¦¦pt_BR
dc.sponsorship.butantanSwedish Foundation for Strategic Research (SSF)¦¦K2014-56X-13413-15-3pt_BR
dc.sponsorship.butantanSwedish Research Council¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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