Early peritoneal CC chemokine production correlates with divergent inflammatory phenotypes and susceptibility to experimental arthritis in mice

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dc.contributorLaboratório de Imunogenéticapt_BR
dc.contributor.authorRossato, Cristianopt_BR
dc.contributor.authorCosta, Layra Lucy Maria Albuquerque dapt_BR
dc.contributor.authorKatz, Iana Suly Santospt_BR
dc.contributor.authorBorrego, Andreapt_BR
dc.contributor.authorCabrera, Wafa Hanna Kourypt_BR
dc.contributor.authorSpadafora-Ferreira, Mônicapt_BR
dc.contributor.authorRibeiro, Orlando Garciapt_BR
dc.contributor.authorStarobinas, Nancypt_BR
dc.contributor.authorIbañez, Olga Célia Martinezpt_BR
dc.contributor.authorDe Franco, Marcelopt_BR
dc.contributor.authorJensen, José Ricardopt_BR
dc.date.accessioned2020-07-09T21:23:20Z-
dc.date.available2020-07-09T21:23:20Z-
dc.date.issued2019-
dc.identifier.citationRossato C, Costa LLMA, Katz ISS, Borrego A, Cabrera WHK, Spadafora-Ferreira M, et al. Early peritoneal CC chemokine production correlates with divergent inflammatory phenotypes and susceptibility to experimental arthritis in mice. Biomed Res Int. 2019;2019:2641098. doi:10.1155/2019/2641098.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2701-
dc.description.abstractThe inflammatory and autoimmune events preceding clinical symptoms in rheumatoid arthritis (RA) and other autoimmune diseases are difficult to study in human patients. Therefore, animal models that share immunologic and clinical features with human RA, such as pristane-induced arthritis (PIA), are valuable tools for assessing the primordial events related to arthritis susceptibility. PIA-resistant HIII and susceptible LIII mice were injected i.p. with pristane, and peritoneal lavage fluid was harvested in the early (7 days) and late (35 days) preclinical phases of PIA. Chemokine and cytokine levels were measured in lavage supernatant with ELISA, peritoneal inflammatory leukocytes were immunophenotyped by flow cytometry, and gene expression was determined by qRT-PCR. Leukocyte recruitment was quantitatively and qualitatively divergent in the peritoneum of HIII and LIII mice, with an early increase of CC chemokines (CCL2/CCL3/CCL5/CCL12/CCL22) in the susceptible LIII strain. Also, cytokines such as IL-12p40, IL-23, and IL-18 were elevated in LIII mice while IL-6 was increased in HIII animals. The results show that an early peritoneal CC chemokine response is an important feature of arthritis susceptibility and defines potential biomarkers in this model.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent2641098pt_BR
dc.languageengpt_BR
dc.relation.ispartofBioMed Research Internationalpt_BR
dc.rightsOpen Accesspt_BR
dc.titleEarly peritoneal CC chemokine production correlates with divergent inflammatory phenotypes and susceptibility to experimental arthritis in micept_BR
dc.typeArticlept_BR
dc.identifier.doi10.1155/2019/2641098pt_BR
dc.identifier.urlhttps://doi.org/10.1155/2019/2641098pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalUnião Educacional do Norte (UNINORTE)pt_BR
dc.contributor.externalInstituto Pasteur¦¦Brasilpt_BR
dc.identifier.citationvolume2019pt_BR
dc.relation.ispartofabbreviatedBiomed Res Intpt_BR
dc.identifier.citationabntv. 2019, 2641098, 2019pt_BR
dc.identifier.citationvancouver2019;2019:2641098pt_BR
dc.contributor.butantanRossato, Cristiano|:Aluno|:Laboratório de Imunogenética|:PrimeiroAutorpt_BR
dc.contributor.butantanBorrego, Andrea|:Pesquisador|:Laboratório de Imunogenética|:pt_BR
dc.contributor.butantanCabrera, Wafa Hanna Koury|:Pesquisador|:Laboratório de Imunogenética|:pt_BR
dc.contributor.butantanSpadafora-Ferreira, Mônica|:Pesquisador|:Laboratório de Imunogenética|:pt_BR
dc.contributor.butantanRibeiro, Orlando Garcia|:Pesquisador|:Laboratório de Imunogenética|:pt_BR
dc.contributor.butantanStarobinas, Nancy|:Pesquisador|:Laboratório de Imunogenética|:pt_BR
dc.contributor.butantanIbañez, Olga Célia Martinez|:Pesquisador|:Laboratório de Imunogenética|:pt_BR
dc.contributor.butantanDe Franco, Marcelo|:Pesquisador|:Laboratório de Imunogenética|:pt_BR
dc.contributor.butantanJensen, José Ricardo|:Pesquisador|:Laboratório de Imunogenética|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦12/50764-4pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
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