Distinct environmental enrichment protocols reduce anxiety but differentially modulate pain sensitivity in rats

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dc.contributorLaboratório de Dor e Sinalizaçãopt_BR
dc.contributorBiotério Centralpt_BR
dc.contributor.authorKimura, Louise Faggionatopt_BR
dc.contributor.authorMattaraia, Vânia Gomes de Mourapt_BR
dc.contributor.authorPicolo, Giselept_BR
dc.date.accessioned2020-07-09T21:23:41Z-
dc.date.available2020-07-09T21:23:41Z-
dc.date.issued2019pt_BR
dc.identifier.citationKimura LF, Mattaraia VGM, Picolo G. Distinct environmental enrichment protocols reduce anxiety but differentially modulate pain sensitivity in rats. Behav Brain Res. 2019 May;364,442-446. doi:10.1016/j.bbr.2017.11.012.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2727-
dc.description.abstractEnvironmental enrichment (EE) can alter anxiety as well as perception of nociceptive stimuli, suggesting a relationship between well-being and analgesia. Considering that, we aimed to evaluate the influence of different EE types on anxiety and peripheral pain sensitivity of male Wistar rats. Animals were submitted to two different types of EE: On the first one, animals were housed in standard size cages after weaning and received three different objects, one type per week, on a regular basis (simple EE – sEE). On the second one, animals were born in an already enriched environment and, after five weeks, were housed in larger cages and received five different objects, three of each type per week, on a regular basis (improved EE – iEE). Control group remained in standard cages and did not receive objects. Within 7 weeks of life, anxiety and thermal sensibility were evaluated using elevated plus maze and tail flick tests, respectively. Mechanical hyperalgesia was analyzed in the presence of acute and chronic noxious stimuli by paw pressure test. Both EE protocols tested were effective in diminish anxiety but they did not alter thermal sensibility. On the other hand, sEE protocol did not alter acute and chronic induced mechanical hypersensitivity, whereas iEE completely abolished such pain behavior, even without exercise wheel as part of the enrichment. Our results show that specific parameters (anxiety and pain sensitivity) can be differentially modulated depending on EE protocol used, making possible the implementation of welfare to experimental animals in pain research.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipInstituto Nacional de Ciência e Tecnologia em Toxinas (INCT-TOX)pt_BR
dc.format.extentp. 442-446pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofBehavioural Brain Researchpt_BR
dc.titleDistinct environmental enrichment protocols reduce anxiety but differentially modulate pain sensitivity in ratspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.bbr.2017.11.012pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.bbr.2017.11.012pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume364pt_BR
dc.subject.keywordWelfarept_BR
dc.subject.keywordEnvironmental enrichmentpt_BR
dc.subject.keywordAnxietypt_BR
dc.subject.keywordAcute painpt_BR
dc.subject.keywordChronic painpt_BR
dc.relation.ispartofabbreviatedBehav Brain Respt_BR
dc.identifier.citationabntv. 364, p. 442-446, mai. 2019pt_BR
dc.identifier.citationvancouver2019 May;364,442-446pt_BR
dc.contributor.butantanKimura, Louise Faggionato|:Aluno|:Laboratório de Dor e Sinalização|:PrimeiroAutorpt_BR
dc.contributor.butantanPicolo, Gisele|:Pesquisador:Docente Permanente PPGTOX|:Laboratório de Dor e Sinalização|:Autor de correspondênciapt_BR
dc.contributor.butantanMattaraia, Vânia Gomes de Moura|:Pesquisador|:Biotério Central|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦141161/2013-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/20795-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/17974-2pt_BR
dc.sponsorship.butantanInstituto Nacional de Ciência e Tecnologia em Toxinas (INCT-TOX)¦¦2008/57898-0pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
item.grantfulltextembargo_29990101-
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crisitem.author.orcid0000-0001-9986-4754-
crisitem.author.orcid0000-0001-6784-8266-
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