Ubiquitin proteasome system (UPS) activation in the cardiac hypertrophy of hyperthyroidism

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dc.contributorLab. Biofísicapt_BR
dc.contributor.authorLino, Caroline Antunespt_BR
dc.contributor.authorDemasi, Marilenept_BR
dc.contributor.authorBarreto-Chaves, Maria Luizapt_BR
dc.date.accessioned2020-07-09T21:24:15Z-
dc.date.available2020-07-09T21:24:15Z-
dc.date.issued2019pt_BR
dc.identifier.citationLino CA, Demasi M, Barreto-Chaves ML. Ubiquitin proteasome system (UPS) activation in the cardiac hypertrophy of hyperthyroidism. Mol. cell. endocrinol.. 2019 Aug;493:110451. doi:10.1016/j.mce.2019.110451.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2769-
dc.description.abstractUbiquitin proteasome system (UPS) is the main proteolytic pathway in eukaryotic cells. Changes in proteasome expression and activity have been associated to cardiovascular diseases as cardiac hypertrophy. Considering that cardiac hypertrophy is commonly associated to hyperthyroidism condition, the present study aimed to investigate the contribution of UPS in cardiac hypertrophy induced by thyroid hormones. Hyperthyroidism was induced in male Wistar rats by intraperitoneal injections of triiodothyronine (T3; 7 µg/100g of body weight) for 7 days and confirmed by raised levels of total T3 and decreased levels of total T4. In addition, systolic blood pressure and heart rate were significantly increased in hyperthyroid group. Cardiac hypertrophy was confirmed in hyperthyroid group by increased heart weight/tibia length ratio and by increased a-MHC/ß-MHC relative expression. Both catalytic (20SPT) and regulatory subunits (19SPT) of the constitutive proteasome were upregulated in hyperthyroid hearts. In addition, the transcripts that encode immunoproteasome subunits were also elevated. Furthermore, ATP-dependent chymotrypsin-like activity (26SPT) was significantly increased in hyperthyroid group. Despite the upregulation and activation of UPS in hyperthyroid hearts, the content of polyubiquitinated proteins was unaltered in relation to control. Together, these results evidence the activation of cardiac proteasome by thyroid hormones, which possibly contribute to the maintenance of protein quality control and regulation of cardiac hypertrophy in response to thyroid hormones.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent110451pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofMolecular and Cellular Endocrinologypt_BR
dc.titleUbiquitin proteasome system (UPS) activation in the cardiac hypertrophy of hyperthyroidismpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.mce.2019.110451pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.mce.2019.110451pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume493pt_BR
dc.subject.keywordProteolysispt_BR
dc.subject.keywordprotein quality controlpt_BR
dc.subject.keywordthyroid hormonept_BR
dc.subject.keywordheartpt_BR
dc.subject.keywordproteasomept_BR
dc.relation.ispartofabbreviatedMol cell endocrinolpt_BR
dc.identifier.citationabntv. 493, 110451, ago. 2019pt_BR
dc.identifier.citationvancouver2019 Aug;493:110451pt_BR
dc.contributor.butantanDemasi, Marilene|:Pesquisador|:Lab. Biofísica|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦305182/2014-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/01291-3pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
item.languageiso639-1English-
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crisitem.author.orcid0000-0002-3749-1160-
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