QseC signaling in the outbreak O104:H4 escherichia coli strain combines multiple factors during infection

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dc.contributorLab. Bacteriologiapt_BR
dc.contributor.authorRibeiro, Tamara Renata Machadopt_BR
dc.contributor.authorLustri, Bruna Cardinalipt_BR
dc.contributor.authorElias, Waldir Pereirapt_BR
dc.contributor.authorMoreira, Cristiano Gallinapt_BR
dc.date.accessioned2020-07-09T21:24:59Z-
dc.date.available2020-07-09T21:24:59Z-
dc.date.issued2019pt_BR
dc.identifier.citationRibeiro TRM, Lustri BC, Elias WP, Moreira CG. QseC signaling in the outbreak O104:H4 escherichia coli strain combines multiple factors during infection. . 2019 Aug;201(17):e00203-19. doi:10.1128/JB.00203-19.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2825-
dc.description.abstractEnteroaggregative Escherichia coli (EAEC) from the O104:H4 specific serotype caused a large outbreak of bloody diarrhea with some complicated cases of hemolytic-uremic syndrome (HUS) in Europe in 2011. The outbreak strain consisted in an EAEC capable to produce the Shiga toxin (Stx) subtype 2a, a characteristic from enterohemorrhagic E. coli. QseBC two-component system detects AI-3/Epi/NE and mediates the chemical signaling between pathogen and mammalian host. This system coordinates a cascade of virulence genes expression in important human enteropathogens. The blocking of QseC of EAEC C227-11 (Stx) strain by N-phenyl-4- {[(phenylamino) thioxomethyl]amino}-benzenesulfonamide (also known as LED209) in vivo demonstrated a lower efficiency of colonization. The periplasmic protein VisP, which is related to survival mechanisms in a colitis model of infection, bacterial membrane maintenance, and stress resistance, here presented high levels of expression during the initial infection within the host. Under acid stress conditions, visP expression levels were differentiated in an Stx-dependent way. Together, these results emphasize the important role of VisP and the histidine kinase sensor QseC in the C227-11 (Stx) outbreak strain for the establishment of the infectious niche process in the C57BL/6 mouse model and of LED209 as a promising antivirulence drug strategy against these enteric pathogens.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extente00203-19pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Bacteriologypt_BR
dc.titleQseC signaling in the outbreak O104:H4 escherichia coli strain combines multiple factors during infectionpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1128/JB.00203-19pt_BR
dc.identifier.urlhttps://doi.org/10.1128/JB.00203-19pt_BR
dc.contributor.externalUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP)¦¦Brasilpt_BR
dc.identifier.citationvolume201pt_BR
dc.identifier.citationissue17pt_BR
dc.subject.keywordEAECpt_BR
dc.subject.keywordEscherichia colipt_BR
dc.subject.keywordO104:H4pt_BR
dc.subject.keywordQseCpt_BR
dc.subject.keywordShiga toxinpt_BR
dc.subject.keywordVisPpt_BR
dc.subject.keywordchemical signalingpt_BR
dc.relation.ispartofabbreviatedJ Bacteriolpt_BR
dc.identifier.citationabntv. 201, n. 17, e00203-19, aug. 2019pt_BR
dc.identifier.citationvancouver2019 Aug;201(17):e00203-19pt_BR
dc.contributor.butantanElias, Waldir Pereira|:Pesquisador|:Lab. Bacteriologiapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦441884/2014-8pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/06779-2pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
item.grantfulltextembargo_29990101-
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