Iron (III)-promoted synthesis of substituted 4H-Chalcogenochromenes and chemoselective functionalization

The iron(III)-promoted synthesis of densely-substituted 4H-chalcogenchromene from organochalcogen propargylamines in the presence of diaryl dichalcogenides is reported. Subsequent C2-functionalization with electrophiles and potassium trifluoroborate salts via Suzuki-Miyaura coupling reaction are also presented. A plausible mechanism based on HRMS experiments is proposed and discussed.
Keywords
Chalcogen;  4H-Chalcogenochromenes;  Heterocycles;  Iron;  Propargylamines

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Oliveira IM., Esteves C.HA., Darbem MP., Pimenta DC, Zukerman-Schpector J, Ferreira AG., et al. Iron (III)-promoted synthesis of substituted 4H-Chalcogenochromenes and chemoselective functionalization. Adv. synth. catal.. 2019 Apr;361(13):3163-3172. doi:10.1002/adsc.201900142.
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