Low accuracy of microscopic hematuria in detecting coagulopathy from Bothrops pit viper bites, Brazilian Amazon

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dc.contributorLaboratório de Artrópodespt_BR
dc.contributor.authorSousa, José Diego de Britopt_BR
dc.contributor.authorOliveira, Sâmella Silva dept_BR
dc.contributor.authorSachett, Jacquelinept_BR
dc.contributor.authorFan, Hui Wenpt_BR
dc.contributor.authorMonteiro, Wuelton Marcelopt_BR
dc.date.accessioned2020-07-09T21:25:18Z-
dc.date.available2020-07-09T21:25:18Z-
dc.date.issued2019pt_BR
dc.identifier.citationSousa JDB, Oliveira SS, Sachett J, Fan HW, Monteiro WM. Low accuracy of microscopic hematuria in detecting coagulopathy from Bothrops pit viper bites, Brazilian Amazon. Clin. Toxicol.. 2019 Feb;57(9):816-818. doi:10.1080/15563650.2018.1560463.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2847-
dc.description.abstractIntroduction: The common lancehead snakes (Bothrops atrox) are responsible for up to 90% of snakebites in the Amazon, especially in remote areas. The prevalence of microhematuria is similar to that of coagulopathy in B. atrox envenomation in the Amazon. Thus, this study aimed to assess the reliability of microhematuria as an inexpensive and simple alternative to detect snake-induced consumption coagulopathy. Methods: We analyzed samples from patients with confirmed B. atrox envenomation in terms of plasma fibrinogen and microhematuria (>3 red blood cells per high power field) in order to access the reliability of microhematuria to detect snakebite-induced coagulopathy, within 12 hours from admission. Results: A total of 186 patients were recruited. From the total, 85.5% of patients had hypofibrinogenemia and only about 50% (n = 94) had a microscopic examination of urine within 12 hours where microhematuria was present in 39 (41.5%). Diagnostic performance showed 38.6% sensitivity and 36.4% specificity (cutpoint 200 mg/dL). No clear association was seen between microhematuria and hypofibrinogenemia (r: -0.10; p: .34). Conclusion: In this study, microhematuria presented poor diagnostic performance to detect coagulopathy. Further studies are necessary to screen inexpensive and simple alternative diagnostic tools.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extent816-818pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofClinical Toxicologypt_BR
dc.titleLow accuracy of microscopic hematuria in detecting coagulopathy from Bothrops pit viper bites, Brazilian Amazonpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1080/15563650.2018.1560463pt_BR
dc.identifier.urlhttps://doi.org/10.1080/15563650.2018.1560463pt_BR
dc.contributor.externalUniversidade do Estado do Amazonas (UEA)¦¦Brasilpt_BR
dc.contributor.externalFundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD)pt_BR
dc.identifier.citationvolume57pt_BR
dc.identifier.citationissue9pt_BR
dc.subject.keywordMicrohematuriapt_BR
dc.subject.keywordsnakebitept_BR
dc.subject.keywordcoagulopathypt_BR
dc.subject.keywordsensitivitypt_BR
dc.relation.ispartofabbreviatedClin Toxicolpt_BR
dc.identifier.citationabntv. 57, n. 9, p. 816-818, feb. 2019pt_BR
dc.identifier.citationvancouver2019 Feb;57(9):816-818pt_BR
dc.contributor.butantanFan, Hui Wen|:Pesquisador|:Laboratório de Artrópodes|:pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦001pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM)¦¦287/2013pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextSem Texto completo-
item.grantfulltextnone-
item.languageiso639-1English-
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