HIV-1 genetic diversity and divergence and its correlation with disease progression among antiretroviral naïve recently infected individuals

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dc.contributorLETA - Laboratório de Toxinologia Aplicadapt_BR
dc.contributor.authorLeda, Ana Rachelpt_BR
dc.contributor.authorHunter, Jamespt_BR
dc.contributor.authorOliveira, Ursula Castro dept_BR
dc.contributor.authorJunqueira-de-Azevedo, Inácio de Loiola Meirellespt_BR
dc.contributor.authorKallas, Esper G.pt_BR
dc.contributor.authorSucupira, Maria Cecilia Araripept_BR
dc.contributor.authorDiaz, Ricardo Sobhiept_BR
dc.date.accessioned2020-07-09T21:26:00Z-
dc.date.available2020-07-09T21:26:00Z-
dc.date.issued2020pt_BR
dc.identifier.citationLeda AR, Hunter J, Oliveira UC, Junqueira-de-Azevedo ILM, Kallas EG., Sucupira MCA, et al. HIV-1 genetic diversity and divergence and its correlation with disease progression among antiretroviral naïve recently infected individuals. Virology. 2020 Feb;541:13-24. doi:10.1016/j.virol.2019.11.006Get.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2901-
dc.description.abstractHIV-1 genetic diversity evolution was deeply characterized during the first year of infection among recently-infected patients using deep sequencing technology and correlated with disease progression surrogate markers. RNA and DNA samples from twenty-five individuals (13 female) encoding the protease and reverse transcriptase regions of the pol gene, and the V3 region of the env gene were evaluated at recent infection and during established infection. Infection by a unique HIV-1 strain was inferred in 70.1% of the individuals, with no differences between genders. Infections by multiple strains were associated with higher viral loads and faster CD4+ T cell declines. Either low or high levels of viral loads accompanied low levels of genetic diversity and lower selective pressure. With massive sequence data from 3 distinct genomic HIV-1 regions from plasma and PBMCs over time, we propose a model for HIV-1 genetic diversity, which correlates to basal viral loads of patients.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extent13-24pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofVirologypt_BR
dc.titleHIV-1 genetic diversity and divergence and its correlation with disease progression among antiretroviral naïve recently infected individualspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.virol.2019.11.006pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.virol.2019.11.006pt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume541pt_BR
dc.relation.ispartofabbreviatedVirologypt_BR
dc.identifier.citationabntv. 541, p. 13-24, fev. 2020pt_BR
dc.identifier.citationvancouver2020 Feb;541:13-24pt_BR
dc.contributor.butantanJunqueira-de-Azevedo, Inácio de Loiola Meirelles|:Pesquisador:Docente Permanente PPGTOX|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.contributor.butantanOliveira, Ursula Castro de|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/12156-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/50238-8pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
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item.grantfulltextembargo_29990101-
item.languageiso639-1English-
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