Crotoxin conjugated to SBA-15 nanostructured mesoporous silica induces long-last analgesic effect in the neuropathic pain model in mice

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dc.contributorLEDS - Laboratório de Dor e Sinalizaçãopt_BR
dc.contributorLab. Imunoquímicapt_BR
dc.contributor.authorSant´Anna, Morena Brazil Martinspt_BR
dc.contributor.authorLopes, Flávia Souza Ribeiropt_BR
dc.contributor.authorKimura, Louise Faggionatopt_BR
dc.contributor.authorGiardini, Aline Carolinapt_BR
dc.contributor.authorSant'Anna, Osvaldo Augusto Brazil Estevespt_BR
dc.contributor.authorPicolo, Giselept_BR
dc.date.accessioned2020-07-09T21:26:10Z-
dc.date.available2020-07-09T21:26:10Z-
dc.date.issued2019pt_BR
dc.identifier.citationSant´Anna MBM, Lopes FSR, Kimura LF, Giardini AC, Sant'Anna OABE, Picolo G. Crotoxin conjugated to SBA-15 nanostructured mesoporous silica induces long-last analgesic effect in the neuropathic pain model in mice. Toxins. 2019 Nov;11(12):679. doi:10.3390/toxins11120679.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2915-
dc.description.abstractNeuropathic pain is a disease caused by structural and functional plasticity in central and peripheral sensory pathways that produce alterations in nociceptive processing. Currently, pharmacological treatment for this condition remains a challenge. Crotoxin (CTX), the main neurotoxin of Crotalus durissus terrificus rattlesnake venom, has well described prolonged anti-inflammatory and antinociceptive activities. In spite of its potential benefits, the toxicity of CTX remains a limiting factor for its use. SBA-15 is an inert nanostructured mesoporous silica that, when used as a vehicle, may reduce toxicity and potentiate the activity of different compounds. Based on this, we propose to conjugate crotoxin with SBA-15 (CTX:SBA-15) in order to investigate if when adsorbed to silica, CTX would have its toxicity reduced and its analgesic effect enhanced in neuropathic pain induced by the partial sciatic nerve ligation (PSNL) model. SBA-15 enabled an increase of 35% of CTX dosage. Treatment with CTX:SBA-15 induced a long-lasting reduction of mechanical hypernociception, without modifying the previously known pathways involved in antinociception. Moreover, CTX:SBA-15 reduced IL-6 and increased IL-10 levels in the spinal cord. Surprisingly, the antinociceptive effect of CTX:SBA-15 was also observed after oral administration. These data indicate the potential use of the CTX:SBA-15 complex for neuropathic pain control and corroborates the protective potential of SBA-15pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extent679pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxinspt_BR
dc.rightsOpen Accesspt_BR
dc.titleCrotoxin conjugated to SBA-15 nanostructured mesoporous silica induces long-last analgesic effect in the neuropathic pain model in micept_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/toxins11120679pt_BR
dc.identifier.urlhttps://doi.org/10.3390/toxins11120679pt_BR
dc.identifier.citationvolume11pt_BR
dc.identifier.citationissue12pt_BR
dc.subject.keywordneuropathic pain 1pt_BR
dc.subject.keywordcrotoxin 2pt_BR
dc.subject.keywordSBA-15 nanostructured silica 3pt_BR
dc.subject.keywordpartial sciatic nerve ligation 4pt_BR
dc.subject.keywordanalgesia 5pt_BR
dc.subject.keywordhypernociception 6pt_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 11, n. 12, p. 679, nov. 2019pt_BR
dc.identifier.citationvancouver2019 Nov;11(12):679pt_BR
dc.contributor.butantanSant'Anna, Morena Brazil Martins|:Aluno|:LEDS - Laboratório de Dor e Sinalização|:PrimeiroAutorpt_BR
dc.contributor.butantanPicolo, Gisele|:Pesquisador:Docente Permanente PPGTOX|:LEDS - Laboratório de Dor e Sinalização|:Autor de correspondênciapt_BR
dc.contributor.butantanLopes, Flavia Souza Ribeiro|:Aluno|:LEDS - Laboratório de Dor e Sinalização|:pt_BR
dc.contributor.butantanKimura, Louise Faggionato|:Aluno|:LEDS - Laboratório de Dor e Sinalização|:pt_BR
dc.contributor.butantanGiardini, Aline Carolina|:Aluno|:LEDS - Laboratório de Dor e Sinalização|:pt_BR
dc.contributor.butantanSant'Anna, Osvaldo Augusto Brazil Esteves|:Pesquisador|:Lab. Imunoquímica|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦2008/57898-0pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦001pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/19397-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/01254-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/17844-8pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.subject.researchlineToxinas e sistemas biológicospt_BR
dc.description.dbindexedYespt_BR
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item.languageiso639-1English-
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