NFKF is a synthetic fragment derived from rat hemopressin that protects mice from neurodegeneration

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dc.contributorLaboratório de Dor e Sinalizaçãopt_BR
dc.contributor.authorHeimann, Andrea S.pt_BR
dc.contributor.authorGiardini, Aline Carolinapt_BR
dc.contributor.authorSant´Anna, Morena Brazil Martinspt_BR
dc.contributor.authorSantos, Nilton B. dospt_BR
dc.contributor.authorGewehr, Mayara C.F.pt_BR
dc.contributor.authorMunhoz, Carolina D.pt_BR
dc.contributor.authorCastro, Leandro M.pt_BR
dc.contributor.authorPicolo, Giselept_BR
dc.contributor.authorRemer, Ricardo A.pt_BR
dc.contributor.authorFerro, Emer S.pt_BR
dc.date.accessioned2020-07-09T21:26:15Z-
dc.date.available2020-07-09T21:26:15Z-
dc.date.issued2020pt_BR
dc.identifier.citationHeimann AS., Giardini AC, Sant´Anna MBM, Santos NB., Gewehr MC.F., Munhoz CD., et al. NFKF is a synthetic fragment derived from rat hemopressin that protects mice from neurodegeneration. Neurosci. Lett.. 2020 Jan;721:134765. doi:10.1016/j.neulet.2020.134765.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2921-
dc.description.abstractPrevious studies suggested the pharmacological potential of rat hemopressin (PVNFKFLSH) and its shorter synthetic peptide NFKF, to protect from pilocarpine-induced seizures in mice. Orally administered NFKF was shown to be hundred times more potent than cannabidiol in delaying the first seizure induced by pilocarpine in mice. Here, using an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis we have shown that C57BL/6J mice orally administrated with NFKF (500µg/kg) presented better EAE clinical scores and improved locomotor activity compared to saline administrated control mice. NFKF blocked the production of IL-1beta and IL-6, and has high scores binding cannabinoid type 2 receptors. Therefore, NFKF is an exciting new possibility to neurodegenerative diseases therapeutics.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent134765pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofNeuroscience Letterspt_BR
dc.titleNFKF is a synthetic fragment derived from rat hemopressin that protects mice from neurodegenerationpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.neulet.2020.134765pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.neulet.2020.134765pt_BR
dc.contributor.externalProteimax Biotecnologia¦¦Brasilpt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.externalUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP)pt_BR
dc.contributor.externalRemer Consultores¦¦Brasilpt_BR
dc.identifier.citationvolume721pt_BR
dc.subject.keywordneurodegenerative diseasespt_BR
dc.subject.keywordintracellular peptidespt_BR
dc.subject.keywordcannabinoidpt_BR
dc.subject.keywordEAEpt_BR
dc.relation.ispartofabbreviatedNeurosci Lettpt_BR
dc.identifier.citationabntv. 721, 134765, jan. 2020pt_BR
dc.identifier.citationvancouver2020 Jan;721:134765pt_BR
dc.contributor.butantanPicolo, Gisele|:Pesquisador:Docente Permanente PPGTOX|:Laboratório de Dor e Sinalização|:pt_BR
dc.contributor.butantanGiardini, Aline Carolina|:Aluno|:Laboratório de Dor e Sinalização|:pt_BR
dc.contributor.butantanSant'Anna, Morena Brazil Martins|:Aluno|:Laboratório de Dor e Sinalização|:pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦445363/2014-2pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦400944/2014-6pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦400944/2014-6pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2016/04000-3pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
item.languageiso639-1English-
item.openairetypeArticle-
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