Lipoatrophy-associated insulin resistance and hepatic steatosis are attenuated by intake of diet rich in omega 3 fatty acids

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dc.contributorLaboratório Especial de Toxinologia Aplicada (LETA)pt_BR
dc.contributor.authorMoreira, Rafael J.pt_BR
dc.contributor.authorCastro, Ériquept_BR
dc.contributor.authorOliveira, Tiago E.pt_BR
dc.contributor.authorBelchior, Thiagopt_BR
dc.contributor.authorPeixoto, Albert S.pt_BR
dc.contributor.authorChaves-Filho, Adriano B.pt_BR
dc.contributor.authorMoreno, Mayara F.pt_BR
dc.contributor.authorLima, Janayna D.pt_BR
dc.contributor.authorYoshinaga, Marcospt_BR
dc.contributor.authorMiyamoto, Sayuript_BR
dc.contributor.authorMorais, Mychel R. P. T.pt_BR
dc.contributor.authorZorn, Telma M. T.pt_BR
dc.contributor.authorCogliati, Brunopt_BR
dc.contributor.authorIwai, Leo Keipt_BR
dc.contributor.authorPalmisano, Giuseppept_BR
dc.contributor.authorCabral, Fernanda J.pt_BR
dc.contributor.authorFestuccia, Williampt_BR
dc.date.accessioned2020-07-09T21:26:28Z-
dc.date.available2020-07-09T21:26:28Z-
dc.date.issued2020-
dc.identifier.citationMoreira RJ., Castro E, Oliveira TE., Belchior T, Peixoto AS., Chaves-Filho AB., et al. Lipoatrophy-associated insulin resistance and hepatic steatosis are attenuated by intake of diet rich in omega 3 fatty acids. Mol. Nutr. Food. Res.. 2020, Jan;1900833. doi:10.1002/mnfr.201900833.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2936-
dc.description.abstractScope Glucose homeostasis and progression of nonalcoholic fatty liver disease (NAFLD) and hepatomegaly in severe lipoatrophic mice and their modulation by intake of a diet rich in omega 3 (n-3) fatty acids (HFO) are evaluated. Methods and results Severe lipoatrophic mice induced by PPAR-gama deletion exclusively in adipocytes (A-PPARgama KO) and littermate controls (A-PPARgama WT) are evaluated for glucose homeostasis and liver mass, proteomics, lipidomics, inflammation, and fibrosis. Lipoatrophic mice are heavier than controls, severely glucose intolerant, and hyperinsulinemic, and develop NAFLD characterized by increased liver glycogen, triacylglycerol, and diacylglycerol contents, mitotic index, apoptosis, inflammation, steatosis score, fibrosis, and fatty acid synthase (FAS) content and activity. Lipoatrophic mice also display liver enrichment with monounsaturated in detriment of polyunsaturated fatty acids including n-3 fatty acids, and increased content of cardiolipin, a tetracyl phospholipid exclusively found at the mitochondria inner membrane. Administration of a high-fat diet rich in n-3 fatty acids (HFO) to lipoatrophic mice enriches liver with n-3 fatty acids, reduces hepatic steatosis, FAS content and activity, apoptosis, inflammation, and improves glucose homeostasis. Conclusion Diet enrichment with n-3 fatty acids improves glucose homeostasis and reduces liver steatosis and inflammation without affecting hepatomegaly in severe lipoatrophic mice.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent1900833pt_BR
dc.languageengpt_BR
dc.relation.ispartofMolecular Nutrition & Food Researchpt_BR
dc.titleLipoatrophy-associated insulin resistance and hepatic steatosis are attenuated by intake of diet rich in omega 3 fatty acidspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1002/mnfr.201900833pt_BR
dc.identifier.urlhttps://doi.org/10.1002/mnfr.201900833pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Estadual de Campinas (UNICAMP)¦¦Brasilpt_BR
dc.subject.keywordinflammationpt_BR
dc.subject.keywordinsulin resistancept_BR
dc.subject.keywordlipoatrophypt_BR
dc.subject.keywordnonalcoholic fatty liver diseasept_BR
dc.subject.keywordomega 3 fatty acidspt_BR
dc.relation.ispartofabbreviatedMol. Nutr. Food. Res.pt_BR
dc.identifier.citationabnt1900833, jan. 2020pt_BR
dc.identifier.citationvancouver2020, Jan;1900833pt_BR
dc.contributor.butantanIwai, Leo Kei|:Pesquisador:Docente Colaborador PPGTOX|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦154750/2014-0pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦303459/2016-6pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07937-8pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/06863-3pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/19530-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/04000-3pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/17943-6pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/15549-1pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
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item.grantfulltextembargo_29990101-
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