Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease

Full metadata record
DC FieldValueLanguage
dc.contributorLab. Farmacologiapt_BR
dc.contributor.authorSilva, Tiago Guardia de Souza ept_BR
dc.contributor.authorPaulo, Maria Eliza Ferreira do Val dept_BR
dc.contributor.authorSilva, Jeferson Rubens Mamona dapt_BR
dc.contributor.authorAlves, Adilson da Silvapt_BR
dc.contributor.authorBritto, Luiz Roberto G.pt_BR
dc.contributor.authorXavier, Gilberto Fernandopt_BR
dc.contributor.authorSandoval, Maria Regina Lopespt_BR
dc.date.accessioned2020-07-09T21:26:29Z-
dc.date.available2020-07-09T21:26:29Z-
dc.date.issued2020pt_BR
dc.identifier.citationSilva TGS, Paulo MEFV, Silva JRM, Alves AS, Britto LRG., Xavier GF, et al. Oral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's disease. Heliyon. 2020 Feb;6(2):e03281. doi:10.1016/j.heliyon.2020.e03281.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2938-
dc.description.abstractAlzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in cognitive function. Intracerebroventricular injection of streptozotocin (icv-STZ) has been used as an experimental model of Sporadic AD (SAD) in rodents and represents a promising tool for etiopathogenic analysis and evaluation of new therapeutic proposals for AD. The icv-STZ model shows many aspects of SAD abnormalities, resulting in decreased brain glucose and energy metabolism, cognitive impairment, oxidative stress, neuronal loss, and amyloid angiopathy. Royal jelly (RJ), a substance produced by worker honeybees of the Apis mellifera species, has been popularly used for more than 30 years in areas related to health eating and natural medicine. Researches indicate that RJ has a several pharmacological activities, including neuroprotective and improvement of cognitive function. The objective of this study was to investigate the effects of oral treatment with royal jelly during 2 weeks in Wistar rats submitted to icv-STZ on a working memory and neuroprotection, as evaluated by neurogenesis, neurodegeneration and oxidative stress. In this study, icv-STZ injection induced deleterious effects in the hippocampus, associated with cognitive impairments, and developed marked neurodegeneration, besides the reduction of neurogenesis and increased oxidative stress. On the other hand, RJ long-term oral administration induced beneficial effects in animals injured by icv-STZ injection, increasing retention time for working spatial memory, reducing neurodegeneration and oxidative stress level and increasing the proliferation of new neurons in the hippocampus. Thus, RJ promotes beneficial effects on cognitive functions and exhibits a neuroprotective action in the STZ experimental model of SAD.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.format.extente03281pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofHeliyonpt_BR
dc.rightsOpen Accesspt_BR
dc.titleOral treatment with royal jelly improves memory and presents neuroprotective effects on icv-STZ rat model of sporadic Alzheimer's diseasept_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.heliyon.2020.e03281pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.heliyon.2020.e03281pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume6pt_BR
dc.identifier.citationissue2pt_BR
dc.subject.keywordNeurosciencept_BR
dc.subject.keywordCell biologypt_BR
dc.subject.keywordPharmaceutical sciencept_BR
dc.subject.keywordLearning and memorypt_BR
dc.subject.keywordNeuroprotectionpt_BR
dc.subject.keywordOxidative stresspt_BR
dc.subject.keywordAlzheimer's diseasept_BR
dc.subject.keywordStreptozotocinpt_BR
dc.subject.keywordRoyal jellypt_BR
dc.relation.ispartofabbreviatedHeliyonpt_BR
dc.identifier.citationabntv. 6, n. 2, e03281, fev. 2020pt_BR
dc.identifier.citationvancouver2020 Feb;6(2):e03281pt_BR
dc.contributor.butantanTiago Guardia de Souza e Silva|:Aluno|:Lab. Farmacologia|:PrimeiroAutorpt_BR
dc.contributor.butantanMaria Eliza Ferreira do Val de Paulo|:Técnico|:Lab. Farmacologia|:pt_BR
dc.contributor.butantanJeferson Rubens Mamona da Silva|:Aluno|:Lab. Farmacologia|:pt_BR
dc.contributor.butantanSandoval, Maria Regina Lopes|:Pesquisador|:Lab. Farmacologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦33002010pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1English-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid0000-0002-7291-8051-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos de periódicos


Files in This Item:

10.1016j.heliyon.2020.e03281.pdf
Size: 4.21 MB
Format: Adobe PDF
View/Open
Show simple item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.