Strategies used by Leptospira spirochetes to evade the host complement system

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dc.contributorLab. Bacteriologiapt_BR
dc.contributor.authorBarbosa, Angela Silvapt_BR
dc.contributor.authorIsaac, Lourdespt_BR
dc.date.accessioned2020-07-09T21:26:52Z-
dc.date.available2020-07-09T21:26:52Z-
dc.date.issued2020pt_BR
dc.identifier.citationBarbosa AS, Isaac L. Strategies used by Leptospira spirochetes to evade the host complement system. FEBS Lett.. 2020 mar;594(16):2633-2644. doi:10.1002/1873-3468.13768.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2970-
dc.description.abstractLeptospires are highly invasive spirochetes equipped with efficient strategies for dissemination in the host. The Leptospira genus currently comprises 64 species divided into two major clades: the saprophytes composed of nonpathogenic, free-living organisms, and the pathogens encompassing all the species that cause mild or severe infections in humans and animals. While saprophytes are highly susceptible to the lytic action of the complement system, pathogenic (virulent) strains have evolved virulence strategies that allow efficient colonization of a variety of hosts and target organs, including mechanisms to circumvent hosts' innate and acquired immune responses. Pathogenic Leptospira avoid complement-mediated killing by recruiting host complement regulatory proteins and by targeting complement proteins using own and host-expressed proteases. This review outlines the role of complement in eradicating saprophytic Leptospira and the stratagems adopted by pathogenic Leptospira to maneuver the host complement system for their benefit.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.format.extent2633-2644pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofFEBS Letterspt_BR
dc.titleStrategies used by Leptospira spirochetes to evade the host complement systempt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1002/1873-3468.13768pt_BR
dc.identifier.urlhttps://doi.org/10.1002/1873-3468.13768pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume594pt_BR
dc.identifier.citationissue16pt_BR
dc.subject.keywordcomplement systempt_BR
dc.subject.keywordimmune evasionpt_BR
dc.subject.keywordLeptospirapt_BR
dc.subject.keywordleptospirosispt_BR
dc.relation.ispartofabbreviatedFEBS Lettpt_BR
dc.identifier.citationabntv. 594, n. 16, p. 2633-2644, mar. 2020pt_BR
dc.identifier.citationvancouver2020 mar;594(16):2633-2644pt_BR
dc.contributor.butantanBarbosa, Angela Silva|:Pesquisador|:Lab. Bacteriologia|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/12924-3pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/12896-2pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
item.languageiso639-1English-
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crisitem.author.orcid0000-0002-6458-9489-
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