Strategies used by Leptospira spirochetes to evade the host complement system
Full metadata record
DC Field | Value | Language |
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dc.contributor | Laboratório de Bacteriologia | pt_BR |
dc.contributor.author | Barbosa, Angela Silva | pt_BR |
dc.contributor.author | Isaac, Lourdes | pt_BR |
dc.date.accessioned | 2020-07-09T21:26:52Z | - |
dc.date.available | 2020-07-09T21:26:52Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Barbosa AS, Isaac L. Strategies used by Leptospira spirochetes to evade the host complement system. FEBS Lett.. 2020 mar;594(16):2633-2644. doi:10.1002/1873-3468.13768. | pt_BR |
dc.identifier.uri | https://repositorio.butantan.gov.br/handle/butantan/2970 | - |
dc.description.abstract | Leptospires are highly invasive spirochetes equipped with efficient strategies for dissemination in the host. The Leptospira genus currently comprises 64 species divided into two major clades: the saprophytes composed of nonpathogenic, free-living organisms, and the pathogens encompassing all the species that cause mild or severe infections in humans and animals. While saprophytes are highly susceptible to the lytic action of the complement system, pathogenic (virulent) strains have evolved virulence strategies that allow efficient colonization of a variety of hosts and target organs, including mechanisms to circumvent hosts' innate and acquired immune responses. Pathogenic Leptospira avoid complement-mediated killing by recruiting host complement regulatory proteins and by targeting complement proteins using own and host-expressed proteases. This review outlines the role of complement in eradicating saprophytic Leptospira and the stratagems adopted by pathogenic Leptospira to maneuver the host complement system for their benefit. | pt_BR |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | pt_BR |
dc.format.extent | 2633-2644 | pt_BR |
dc.language | eng | pt_BR |
dc.relation.ispartof | FEBS Letters | pt_BR |
dc.title | Strategies used by Leptospira spirochetes to evade the host complement system | pt_BR |
dc.type | Article | pt_BR |
dc.identifier.doi | https://repositorio.butantan.gov.br/handle/butantan/2970 | pt_BR |
dc.identifier.url | https://doi.org/10.1002/1873-3468.13768 | pt_BR |
dc.contributor.external | Universidade de São Paulo (USP)¦¦Brasil | pt_BR |
dc.identifier.citationvolume | 594 | pt_BR |
dc.identifier.citationissue | 16 | pt_BR |
dc.subject.keyword | complement system | pt_BR |
dc.subject.keyword | immune evasion | pt_BR |
dc.subject.keyword | Leptospira | pt_BR |
dc.subject.keyword | leptospirosis | pt_BR |
dc.relation.ispartofabbreviated | FEBS Lett. | pt_BR |
dc.identifier.citationabnt | v. 594, n. 16, p. 2633-2644, mar. 2020 | pt_BR |
dc.identifier.citationvancouver | 2020 mar;594(16):2633-2644 | pt_BR |
dc.contributor.butantan | Barbosa, Angela Silva|:Pesquisador|:Laboratório de Bacteriologia|:PrimeiroAutor:Autor de correspondência | pt_BR |
dc.sponsorship.butantan | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/12924-3 | pt_BR |
dc.sponsorship.butantan | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/12896-2 | pt_BR |
dc.identifier.bvscc | BR78.1 | pt_BR |
dc.identifier.bvsdb | IBProd | pt_BR |
item.openairetype | Article | - |
item.grantfulltext | embargo_29990101 | - |
item.fulltext | Com Texto completo | - |
crisitem.journal.journalissn | #PLACEHOLDER_PARENT_METADATA_VALUE# | - |
crisitem.journal.journaleissn | #PLACEHOLDER_PARENT_METADATA_VALUE# | - |
crisitem.author.dept | #PLACEHOLDER_PARENT_METADATA_VALUE# | - |
crisitem.author.dept | #PLACEHOLDER_PARENT_METADATA_VALUE# | - |
crisitem.author.orcid | #PLACEHOLDER_PARENT_METADATA_VALUE# | - |
crisitem.author.orcid | #PLACEHOLDER_PARENT_METADATA_VALUE# | - |
crisitem.author.parentorg | #PLACEHOLDER_PARENT_METADATA_VALUE# | - |
Appears in Collections: | Artigos de periódicos |
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