Tb1, a neurotoxin from Tityus bahiensis scorpion venom, induces epileptic seizures by increasing glutamate release

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dc.contributorLab. Farmacologiapt_BR
dc.contributorLab. Biofísicapt_BR
dc.contributor.authorBeraldo Neto, Emidiopt_BR
dc.contributor.authorFreitas, Lucas Alves dept_BR
dc.contributor.authorPimenta, Daniel Carvalhopt_BR
dc.contributor.authorLebrun, Ivopt_BR
dc.contributor.authorNencioni, Ana Leonor Abrahãopt_BR
dc.date.accessioned2020-07-09T21:27:16Z-
dc.date.available2020-07-09T21:27:16Z-
dc.date.issued2020pt_BR
dc.identifier.citationBeraldo Neto E, Freitas LA, Pimenta DC, Lebrun I, Nencioni ALA. Tb1, a neurotoxin from Tityus bahiensis scorpion venom, induces epileptic seizures by increasing glutamate release. Toxins. 2020 Jan;12(2):65. doi:10.3390/toxins12020065.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2997-
dc.description.abstractHere, we report the neurotoxic effects aroused by the intracerebral injection (in rats) of Tb1, which is a neurotoxin isolated from Tityus bahiensis scorpion venom. Biochemical analyses have demonstrated that this toxin is similar to the gamma toxin from T. serrulatus, which is a ß-scorpion toxin that acts on sodium channels, causing the activation process to occur at more hyperpolarized membrane voltages. Male Wistar rats were stereotaxically implanted with intrahippocampal electrodes and cannulas for electroencephalographic recording and the evaluation of amino acid neurotransmitters levels. Treated animals displayed behavioral and electroencephalographic alterations similar to epileptiform activities, such as myoclonus, wet dog shakes, convulsion, strong discharges, neuronal loss, and increased intracerebral levels of glutamate. Scorpion toxins are important pharmacological tools that are widely employed in ion channel dysregulation studies. The current work contributes to the understanding of channelopathies, particularly epilepsy, which may originate, among other events, from dysfunctional sodium channels, which are the main target of the Tb1 toxinpt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent65pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxinspt_BR
dc.rightsOpen Accesspt_BR
dc.titleTb1, a neurotoxin from Tityus bahiensis scorpion venom, induces epileptic seizures by increasing glutamate releasept_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/toxins12020065pt_BR
dc.identifier.urlhttps://doi.org/10.3390/toxins12020065pt_BR
dc.identifier.citationvolume12pt_BR
dc.identifier.citationissue2pt_BR
dc.subject.keywordscorpion toxinspt_BR
dc.subject.keywordhippocampuspt_BR
dc.subject.keywordseizurespt_BR
dc.subject.keywordneurotransmitterspt_BR
dc.subject.keywordneuronal damagept_BR
dc.subject.keywordepilepsypt_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 12, n. 2, 65. 2020pt_BR
dc.identifier.citationvancouver2020 Jan;12(2):65pt_BR
dc.contributor.butantanBeraldo Neto, Emidio|:Aluno|:Lab. Farmacologia|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanPimenta, Daniel Carvalho|:Pesquisador:Docente Permanente PPGTOX|:Lab. Biofísica|:Autor de correspondênciapt_BR
dc.contributor.butantanLebrun, Ivo|:Pesquisador:Docente Permanente PPGTOX|:Lab. Biofísica|:Autor de correspondênciapt_BR
dc.contributor.butantanNencioni, Ana Leonor Abrahão|:Pesquisador:Docente Colaborador PPGTOX|:Lab. Farmacologia|:pt_BR
dc.contributor.butantanFreitas, Lucas Alves de|:Aluno|:Lab. Farmacologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦406385/2018-1pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦303792/2016-7pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦1207/2011pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦01.09.0278.04pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦01.12.0450.03pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextopen-
item.languageiso639-1English-
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