Medical applications of clustered regularly interspaced short palindromic repeats (CRISPR/Cas) tool: a comprehensive overview

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dc.contributorLaboratório de Genéticapt_BR
dc.contributorLaboratório Especial de Desenvolvimento de Vacinas (LEDV)pt_BR
dc.contributor.authorAraldi, Rodrigo Pinheiropt_BR
dc.contributor.authorKhalil, Charbelpt_BR
dc.contributor.authorGrignet, Pedro Henriquept_BR
dc.contributor.authorTeixeira, Michelli Ramirespt_BR
dc.contributor.authorMelo, Thatiana Correa dept_BR
dc.contributor.authorMódolo, Diego Grandopt_BR
dc.contributor.authorFernandes, Luis Guilherme Vírgíliopt_BR
dc.contributor.authorRuiz, Jorgept_BR
dc.contributor.authorSouza, Edislane Barreiros dept_BR
dc.date.accessioned2020-07-09T21:27:18Z-
dc.date.available2020-07-09T21:27:18Z-
dc.date.issued2020-
dc.identifier.citationAraldi RP, Khalil C, Grignet PH, Teixeira MR, Melo TC, Módolo DG, et al. Medical applications of clustered regularly interspaced short palindromic repeats (CRISPR/Cas) tool: a comprehensive overview. Gene. 2020 Mar;745:144636. doi:10.1016/j.gene.2020.144636.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/2999-
dc.description.abstractSince the discovery of the double helix and the introduction of genetic engineering, the possibility to develop new strategies to manipulate the genome has fascinated scientists around the world. Currently scientists have the knowledge and ability to edit the genomes. Several methodologies of gene editing have been established, all of them working like "scissor", creating double strand breaks at specific spots. The introduction of a new technology, which was adapted from the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas bacterial immune system, has revolutionized the genetic therapy field, as it allows a much more precise editing of gene than the previously described tools and, therefore, to prevent and treat disease in humans. This review aims to revisit the genome editing history that led to the rediscovery of the CRISPR/Cas technology and to explore the technical aspects, applications and perspectives of this fascinating, powerful, precise, simpler and cheaper technology in different fieldspt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipSociedade Brasileira de Endocrinologia e Metabologia (SBEM)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent144636pt_BR
dc.languageengpt_BR
dc.relation.ispartofGenept_BR
dc.titleMedical applications of clustered regularly interspaced short palindromic repeats (CRISPR/Cas) toolpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.gene.2020.144636pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.gene.2020.144636pt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)¦¦Brasilpt_BR
dc.contributor.externalUniversidade Federal da Integração Latino-Americana (UNILA)¦¦Brasilpt_BR
dc.contributor.externalLebanese University¦¦Líbanopt_BR
dc.contributor.externalUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP)¦¦Brasilpt_BR
dc.title.suba comprehensive overviewpt_BR
dc.identifier.citationvolume745pt_BR
dc.subject.keywordCRISPR/Cas9pt_BR
dc.subject.keywordgene editingpt_BR
dc.subject.keywordpersonalized medicinept_BR
dc.subject.keywordtechnical recommendationspt_BR
dc.subject.keywordmedical applicationspt_BR
dc.relation.ispartofabbreviatedGenept_BR
dc.identifier.citationabntv. 745, 144636, mar. 2020pt_BR
dc.identifier.citationvancouver2020 Mar;745:144636pt_BR
dc.contributor.butantanMódolo, Diego Grando|:Aluno|:Laboratório de Genética|:pt_BR
dc.contributor.butantanFernandes, Luis Guilherme Virgílio|:Aluno|:Laboratório Especial de Desenvolvimento de Vacinas (LEDV)|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦408037/2018-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/06570-6pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/14948-7pt_BR
dc.sponsorship.butantanSociedade Brasileira de Endocrinologia e Metabologia (SBEM)¦¦2018pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
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