Dynamic expression of long non-coding RNAs throughout parasite sexual and neural maturation in schistosoma japonicum

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dc.contributorLaboratório de Expressão Gênica em Eucariotospt_BR
dc.contributorLaboratório de Parasitologiapt_BR
dc.contributor.authorMaciel, Lucas Ferreirapt_BR
dc.contributor.authorVicente, David Abraham Moralespt_BR
dc.contributor.authorVerjovski-Almeida, Sergiopt_BR
dc.date.accessioned2020-07-09T21:27:19Z-
dc.date.available2020-07-09T21:27:19Z-
dc.date.issued2020-
dc.identifier.citationMaciel LF, Vicente DAM, Verjovski-Almeida S. Dynamic expression of long non-coding RNAs throughout parasite sexual and neural maturation in schistosoma japonicum. NonCoding RNA. 2020 Mar;6(2):15. doi:10.3390/ncrna6020015.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3000-
dc.description.abstractSchistosoma japonicum is a flatworm that causes schistosomiasis, a neglected tropical disease. S. japonicum RNA-Seq analyses has been previously reported in the literature on females and males obtained during sexual maturation from 14 to 28 days post-infection in mouse, resulting in the identification of protein-coding genes and pathways, whose expression levels were related to sexual development. However, this work did not include an analysis of long non-coding RNAs (lncRNAs). Here, we applied a pipeline to identify and annotate lncRNAs in 66 S. japonicum RNA-Seq publicly available libraries, from different life-cycle stages. We also performed co-expression analyses to find stage-specific lncRNAs possibly related to sexual maturation. We identified 12,291 S. japonicum expressed lncRNAs. Sequence similarity search and synteny conservation indicated that some 14% of S. japonicum intergenic lncRNAs have synteny conservation with S. mansoni intergenic lncRNAs. Co-expression analyses showed that lncRNAs and protein-coding genes in S. japonicum males and females have a dynamic co-expression throughout sexual maturation, showing differential expression between the sexes; the protein-coding genes were related to the nervous system development, lipid and drug metabolism, and overall parasite survival. Co-expression pattern suggests that lncRNAs possibly regulate these processes or are regulated by the same activation program as that of protein-coding genes.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent15pt_BR
dc.languageengpt_BR
dc.relation.ispartofNon-Coding RNApt_BR
dc.rightsOpen Accesspt_BR
dc.titleDynamic expression of long non-coding RNAs throughout parasite sexual and neural maturation in schistosoma japonicumpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/ncrna6020015pt_BR
dc.identifier.urlhttps://doi.org/10.3390/ncrna6020015pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.identifier.citationvolume6pt_BR
dc.identifier.citationissue2pt_BR
dc.subject.keywordparasitologypt_BR
dc.subject.keywordlncRNAspt_BR
dc.subject.keywordWGCNApt_BR
dc.subject.keywordgene co-expression networkpt_BR
dc.subject.keywordsyntenypt_BR
dc.subject.keywordnervous systempt_BR
dc.relation.ispartofabbreviatedNonCoding RNApt_BR
dc.identifier.citationabntv. 6, n. 2, 15, mar. 2020pt_BR
dc.identifier.citationvancouver2020 Mar;6(2):15pt_BR
dc.contributor.butantanMaciel, Lucas Ferreira|:Aluno|:Laboratório de Expressão Gênica em Eucariotos|:PrimeiroAutorpt_BR
dc.contributor.butantanVicente, David Abraham Morales|:Aluno|:Laboratório de Expressão Gênica em Eucariotos|:Autor de correspondênciapt_BR
dc.contributor.butantanVerjovski-Almeida, Sergio|:Pesquisador|:Laboratório de Expressão Gênica em Eucariotos|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/03620-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/23693-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/19591-2pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
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item.openairetypeArticle-
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