The impact of rattlesnake venom on mice cerebellum proteomics points to synaptic inhibition and tissue damage

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dc.contributorLETA - Laboratório de Toxinologia Aplicadapt_BR
dc.contributorLab. Fisiopatologiapt_BR
dc.contributor.authorMontoni, Fabiopt_BR
dc.contributor.authorAndreotti, Diana Zukaspt_BR
dc.contributor.authorEichler, Rosangela Aparecida dos Santospt_BR
dc.contributor.authorSantos, Wellington da Silvapt_BR
dc.contributor.authorKisaki, Carolina Yukikopt_BR
dc.contributor.authorArcos, Stephanie Santos Suehiropt_BR
dc.contributor.authorLima, Ismael Feitosapt_BR
dc.contributor.authorSoares, Magna Aparecida Maltauropt_BR
dc.contributor.authorNishiyama Junior, Milton Yutakapt_BR
dc.contributor.authorNava-Rodrigues, Danielpt_BR
dc.contributor.authorFerro, Emer Suavinhopt_BR
dc.contributor.authorCarvalho, Valdemir Melechcopt_BR
dc.contributor.authorIwai, Leo Keipt_BR
dc.date.accessioned2020-07-09T21:27:21Z-
dc.date.available2020-07-09T21:27:21Z-
dc.date.issued2020pt_BR
dc.identifier.citationMontoni F, Andreotti DZ, Eichler RAS, Santos WS, Kisaki CY, Arcos SSS, et al. The impact of rattlesnake venom on mice cerebellum proteomics points to synaptic inhibition and tissue damage. J. Proteomics. 2020 Jun;221:103779. doi:doi.org/10.1016/j.jprot.2020.103779.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3004-
dc.description.abstractSnake envenomation is responsible for more than 130,000 deaths worldwide. In Brazil, the Crotalus rattlesnake is responsible for the second largest number of accidental snake bites in the country. Although there are many descriptions of the clinical and biochemical effects of Crotalus envenoming, there are few works describing the molecular events in the central nervous system of an organism due to envenomation. In this study, we analyzed the proteomic effect of Crotalus durissus terrificus snake venom on mice cerebellums. To monitor the envenomation over time, changes in the protein abundance were evaluated at 1 h, 6 h, 12 h and 24 h after venom injection by mass spectrometry. The analysis of the variation of over 4600 identified proteins over time showed a reduction in components of inhibitory synapse signaling, oxidative stress, and maintenance of neuronal cells, which paralleled increasing tissue damage and apoptosis factors. These analyses revealed the potential protein targets of the C. d. terrificus venom on the murine cerebellum, showing new aspects of the snake envenomation effect. These data may contribute to new therapeutic approaches (i.e., approaches directed at protein targets affected by the envenomation) on the treatment of envenomation by the neurotoxic C. d. terrificus snake venom. Significance Snakebites are a neglected global health problem that affects mostly rural and tropical areas of developing countries. It is estimated that over 5.4 million people are bitten by snakes each year, from which 2.7 million people are bitten by venomous snakes, resulting in disabilities such as amputations and in some cases leading to death. The C. d. terrificus snake is the most lethal snake in Brazil. Studying the molecular changes upon envenomation in a specific tissue may lead to a better understanding of the envenomation process by C. d. terrificus snakebites.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipUniversidade de São Paulo (USP)pt_BR
dc.format.extent103779pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Proteomicspt_BR
dc.titleThe impact of rattlesnake venom on mice cerebellum proteomics points to synaptic inhibition and tissue damagept_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.jprot.2020.103779pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.jprot.2020.103779pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalGrupo Fleury¦¦Brasilpt_BR
dc.contributor.externalThe Institute of Cancer Research¦¦Inglaterrapt_BR
dc.identifier.citationvolume221pt_BR
dc.subject.keywordMass spectrometrypt_BR
dc.subject.keywordProteome analysispt_BR
dc.subject.keywordCrotalus durissus terrificuspt_BR
dc.subject.keywordSnake envenomationpt_BR
dc.subject.keywordMus musculuspt_BR
dc.subject.keywordCerebellumpt_BR
dc.relation.ispartofabbreviatedJ Proteomicspt_BR
dc.identifier.citationabntv. 221, 103779, jun. 2020pt_BR
dc.identifier.citationvancouver2020 Jun;221:103779pt_BR
dc.contributor.butantanMontoni, Fábio|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA)|:PrimeiroAutorpt_BR
dc.contributor.butantanIwai, Leo Kei|:Pesquisador:Docente Colaborador PPGTOX|:Laboratório Especial de Toxinologia Aplicada (LETA)|:Autor de correspondênciapt_BR
dc.contributor.butantanSantos, Wellington da Silva|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.contributor.butantanKisaki, Carolina Yukiko|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.contributor.butantanArcos, Stephanie Santos Suehiro|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.contributor.butantanLima, Ismael Feitosa|:Técnico|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.contributor.butantanSoares, Magna Aparecida Maltauro|:Técnico|:Lab. Fisiopatologia|:pt_BR
dc.contributor.butantanNishiyama Junior, Milton Yutaka|:Pesquisador|:Laboratório Especial de Toxinologia Aplicada (LETA)|:pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦302809/2016-3pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦88882.442313/2019-01pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/04000-3pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/17943-6pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/50040-4pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/06496-9pt_BR
dc.sponsorship.butantanUniversidade de São Paulo (USP)¦¦131408/2019-4pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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