Early exposure to environmental enrichment protects male rats against neuropathic pain development after nerve injury

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dc.contributorLaboratório Especial de Dor e Sinalização (LEDS)pt_BR
dc.contributorLaboratório de Biologia Celularpt_BR
dc.contributorBiotério Centralpt_BR
dc.contributor.authorKimura, Louise Faggionatopt_BR
dc.contributor.authorSant´Anna, Morena Brazil Martinspt_BR
dc.contributor.authorZambelli, Vanessa Olzonpt_BR
dc.contributor.authorGiardini, Aline Carolinapt_BR
dc.contributor.authorJared, Simone Gonçalves Silvapt_BR
dc.contributor.authorAntoniazzi, Marta Mariapt_BR
dc.contributor.authorMattaraia, Vânia Gomes de Mourapt_BR
dc.contributor.authorPagano, Rosana Limapt_BR
dc.contributor.authorPicolo, Giselept_BR
dc.date.accessioned2020-07-09T21:28:17Z-
dc.date.available2020-07-09T21:28:17Z-
dc.date.issued2020pt_BR
dc.identifier.citationKimura LF, Sant´Anna MBM, Zambelli VO, Giardini AC, Jared SGS, Antoniazzi MM, et al. Early exposure to environmental enrichment protects male rats against neuropathic pain development after nerve injury. Exp. Neurol.. 2020 June;332:113390. doi:10.1016/j.expneurol.2020.113390.pt_BR
dc.identifier.issn0014-4886-
dc.identifier.issn1090-2430-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3080-
dc.description.abstractBecause environmental elements modify chronic pain development and endogenous mechanisms of pain control are still a great therapeutic source, we investigated the effects of an early exposure to environmental enrichment (EE) in a translational model of neuropathic pain. Young male rats born and bred in an enriched environment, which did not count on running wheel, underwent chronic constriction injury (CCI) of sciatic nerve. EE abolished neuropathic pain behavior 14?days after CCI. Opioid receptors' antagonism reversed EE-analgesic effect. ß-endorphin and met-enkephalin serum levels were increased only in EE-CCI group. Blockade of glucocorticoid receptors did not alter EE-analgesic effect, although corticosterone circulating levels were increased in EE animals. In the spinal cord, EE controlled CCI-induced serotonin increase. In DRG, EE blunted the expression of ATF-3 after CCI. Surprisingly, EE-CCI group showed a remarkable preservation of sciatic nerve fibers compared to NE-CCI group. This work demonstrated global effects induced by an EE protocol that explain, in part, the protective role of EE upon chronic noxious stimulation, reinforcing the importance of endogenous mechanisms in the prevention of chronic pain development.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent113390pt_BR
dc.languageengpt_BR
dc.publisherAcademic Presspt_BR
dc.relation.ispartofExperimental Neurologypt_BR
dc.titleEarly exposure to environmental enrichment protects male rats against neuropathic pain development after nerve injurypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.expneurol.2020.113390pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.expneurol.2020.113390pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)¦¦Brasilpt_BR
dc.contributor.externalStanford University¦¦Estados Unidospt_BR
dc.contributor.externalHospital Sírio Libanês¦¦Brasilpt_BR
dc.publisher.cityOrlandopt_BR
dc.identifier.citationvolume332pt_BR
dc.subject.keywordEnvironmental enrichmentpt_BR
dc.subject.keywordChronic neuropathic painpt_BR
dc.subject.keywordNerve injurypt_BR
dc.subject.keywordEndogenous opioidspt_BR
dc.subject.keywordCorticosteronept_BR
dc.subject.keywordSerotoninpt_BR
dc.subject.keywordWallerian degenerationpt_BR
dc.relation.ispartofabbreviatedExp. Neurol.pt_BR
dc.identifier.citationabntv. 332, 113390, jun. 2020pt_BR
dc.identifier.citationvancouver2020 June;332:113390pt_BR
dc.publisher.countryUnited Statespt_BR
dc.contributor.butantanKimura, Louise Faggionato|:Aluno|:Laboratório Especial de Dor e Sinalização (LEDS)|:PrimeiroAutorpt_BR
dc.contributor.butantanSant'Anna, Morena Brazil Martins|:Aluno|:Laboratório Especial de Dor e Sinalização (LEDS)|:pt_BR
dc.contributor.butantanZambelli, Vanessa Olzon|:Pesquisador:Docente Permanente PPGTOX|:Laboratório Especial de Dor e Sinalização (LEDS)|:pt_BR
dc.contributor.butantanGiardini, Aline Carolina|:Aluno|:Laboratório Especial de Dor e Sinalização (LEDS)|:pt_BR
dc.contributor.butantanJared, Simone Gonçalves Silva|:Técnico|:Laboratório de Biologia Celular|:pt_BR
dc.contributor.butantanAntoniazzi, Marta Maria|:Pesquisador:Docente Permanente PPGTOX|:Laboratório de Biologia Celular|:pt_BR
dc.contributor.butantanMattaraia, Vânia Gomes de Moura|:Pesquisador|:Biotério Central|:pt_BR
dc.contributor.butantanPicolo, Gisele|:Pesquisador:Docente Permanente PPGTOX|:Laboratório Especial de Dor e Sinalização (LEDS)|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦141161/2013-2pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2008/57898-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/20795-8pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
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