Insights on zika virus envelope gene conservation in american outbreaks
Phylogenetic studies with Zika virus (ZIKV) have been conducted in Brazil. In this study, we sequenced 8 new sequences of the ZIKV envelope (E) gene from strains of cases from the Paraná and Mato Grosso do Sul states in 2016. A low phylogenetic signal was observed, with more than 40% of unresolved quartets, and the Maximum Likelihood Tree grouped all sequences in the Brazilian branches within the Asian genotype. In addition, a Shannon entropy analysis was conducted, showing a high stability in the E protein through the ZIKV polyprotein. Taken together, these results suggest a high degree of conservation in the ZIKV E gene from the recent American outbreaks.
Zika virus; Phylogenetic study; Entropy; Brazil
Thomazella MV., Lima Neto QA., Duarte Junior FF., Jorge FA., Moreira DC, Leal Junior AD., et al. Insights on zika virus envelope gene conservation in american outbreaks. Braz. J. Microbiol.. 2020 Aug. doi:10.1007/s42770-020-00349-3.
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