Prioritisation of potential drug targets against bartonella bacilliformis by an integrative in-silico approach

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dc.contributorLaboratório de Bacteriologiapt_BR
dc.contributor.authorFarfán-López, Mariellapt_BR
dc.contributor.authorEspinoza-Culupú, Abrahampt_BR
dc.contributor.authorGarcía-de-la-Guarda, Ruthpt_BR
dc.contributor.authorSerral, Federicopt_BR
dc.contributor.authorSosa, Ezequielpt_BR
dc.contributor.authorPalomino, María Mercedespt_BR
dc.contributor.authorPorto, Darío A Fernández Dopt_BR
dc.date.accessioned2020-09-08T20:10:53Z-
dc.date.accessioned2020-09-08T20:10:58Z-
dc.date.available2020-09-08T20:10:53Z-
dc.date.available2020-09-08T20:10:58Z-
dc.date.issued2020-
dc.identifier.citationFarfán-López M, Espinoza-Culupú A, García-de-la-Guarda R, Serral F, Sosa E, Palomino MM, et al. Prioritisation of potential drug targets against bartonella bacilliformis by an integrative in-silico approach. Mem. Inst. Oswaldo Cruz. 2020 Jul;115:e200184. doi:10.1590/0074-02760200184.pt_BR
dc.identifier.issn0074-0276-
dc.identifier.issn1678-8060-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3184-
dc.description.abstractBACKGROUND Carrion’s disease (CD) is a neglected biphasic illness caused by Bartonella bacilliformis, a Gram-negative bacteria found in the Andean valleys. The spread of resistant strains underlines the need for novel antimicrobials against B. bacilliformis and related bacterial pathogens. OBJECTIVE The main aim of this study was to integrate genomic-scale data to shortlist a set of proteins that could serve as attractive targets for new antimicrobial discovery to combat B. bacilliformis. METHODS We performed a multidimensional genomic scale analysis of potential and relevant targets which includes structural druggability, metabolic analysis and essentiality criteria to select proteins with attractive features for drug discovery. FINDINGS We shortlisted seventeen relevant proteins to develop new drugs against the causative agent of Carrion’s disease. Particularly, the protein products of fabI, folA, aroA, trmFO, uppP and murE genes, meet an important number of desirable features that make them attractive targets for new drug development. This data compendium is freely available as a web server (http://target.sbg.qb.fcen.uba.ar/).pt_BR
dc.format.extente200184pt_BR
dc.languageengpt_BR
dc.relation.ispartofMemórias do Instituto Oswaldo Cruzpt_BR
dc.titlePrioritisation of potential drug targets against bartonella bacilliformis by an integrative in-silico approachpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1590/0074-02760200184pt_BR
dc.identifier.urlhttp://dx.doi.org/10.1590/0074-02760200184pt_BR
dc.contributor.externalUniversidad Nacional Mayor de San Marcos (UNMSM)pt_BR
dc.contributor.externalUniversidad de Buenos Aires (UBA)pt_BR
dc.identifier.citationvolume115pt_BR
dc.subject.keywordBartonella bacilliformispt_BR
dc.subject.keyworddrug targetspt_BR
dc.subject.keywordstructuromept_BR
dc.subject.keywordmetabolic networkspt_BR
dc.subject.keywordCarrion’s diseasept_BR
dc.relation.ispartofabbreviatedMem. Inst. Oswaldo Cruzpt_BR
dc.identifier.citationabntv. 115, e200184, jul. 2020pt_BR
dc.identifier.citationvancouver2020 Jul;115:e200184pt_BR
dc.contributor.butantanEspinoza-Culupú, Abraham Omar|:Aluno|:Laboratório de Bacteriologiapt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
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