Immunohistochemical detection of Lp25 and LipL32 proteins in skeletal and cardiac muscles of fatal human leptospirosis

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dc.contributorLab. Bacteriologiapt_BR
dc.contributor.authorIglezias, Silvia D’Andrettapt_BR
dc.contributor.authorAbreu, Patricia Antonia Estimapt_BR
dc.contributor.authorKanamura, Cristinapt_BR
dc.contributor.authorMagaldi, Antonio Josépt_BR
dc.contributor.authorSeguro, Antonio Carlospt_BR
dc.contributor.authorBrito, Thales Dept_BR
dc.date.accessioned2020-11-26T13:50:22Z-
dc.date.available2020-11-26T13:50:22Z-
dc.date.issued2020pt_BR
dc.identifier.citationIglezias SDA, Aniz PAEA, Kanamura C, Magaldi AJ, Seguro AC, Brito TD. Immunohistochemical detection of Lp25 and LipL32 proteins in skeletal and cardiac muscles of fatal human leptospirosis. Rev. Inst. Med. Trop. Sao Paulo. 2020 Nov;62:e85. doi:10.1590/s1678-9946202062085.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3306-
dc.description.abstractLeptospirosis is an acute infection caused by pathogenic species of the genus Leptospira, which affects humans and animals in all world. In severe forms of the disease, kidneys, liver and lungs are the main affected organs, resulting in acute kidney injury, jaundice and pulmonary hemorrhage. Previous post-mortem studies have shown that lesions are not limited to these organs. Cardiac and striated muscle injuries have already been reported, but the pathophysiology of cardiac and skeletal lesions in leptospirosis is not fully understood. It has been suggested that the tissue damage observed in leptospirosis could be directly mediated by leptospires or by their toxic cellular components. LipL32 and Lp25 are leptospira membrane proteins with unknown functions, that are present only in pathogenic strains of Leptospira spp. Both proteins induce skeletal muscle lesions similar to those observed when normal guinea pigs are inoculated with leptospires. Through immunohistochemistry, this study showed the presence of LipL32 and Lp25 proteins on muscle cell membranes and in the underlying cytoplasm of skeletal muscles, as well as focal lesions in cardiac tissues of fatal cases of leptospirosis. Altogether, these results reinforce that both proteins can be important factors in the pathogenesis of leptospirosis.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(FESIMA) Fundo Especial de Saúde para Imunização em Massa e Controle de Doençaspt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extente85pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulopt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/pt_BR
dc.titleImmunohistochemical detection of Lp25 and LipL32 proteins in skeletal and cardiac muscles of fatal human leptospirosispt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BY-NCpt_BR
dc.identifier.doi10.1590/s1678-9946202062085pt_BR
dc.identifier.urlhttps://doi.org/10.1590/s1678-9946202062085pt_BR
dc.contributor.externalInstituto Adolfo Lutz (IAL)pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume62pt_BR
dc.subject.keywordLeptospirapt_BR
dc.subject.keywordLeptospirosispt_BR
dc.subject.keywordRhabdomyolysispt_BR
dc.subject.keywordWeil’s diseasept_BR
dc.subject.keywordLp25pt_BR
dc.subject.keywordLipL32pt_BR
dc.relation.ispartofabbreviatedRev Inst Med Trop Sao Paulopt_BR
dc.identifier.citationabntv. 62, e85, nov. 2020pt_BR
dc.identifier.citationvancouver2020 Nov;62:e85pt_BR
dc.contributor.butantanAbreu, Patricia Antonia Estima|:Pesquisador|:Lab. Bacteriologia|:Autor de correspondênciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/00546-0pt_BR
dc.sponsorship.butantan(FESIMA) Fundo Especial de Saúde para Imunização em Massa e Controle de Doenças¦¦2019/03773pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦302599/2018-5pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextopen-
item.languageiso639-1English-
item.fulltextCom Texto completo-
item.openairetypeArticle-
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