Granzyme a in chikungunya and other arboviral infections [DELETAR]

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dc.contributorLaboratório de Bacteriologiapt_BR
dc.contributor.authorSchanoski, Alessandra Soarespt_BR
dc.contributor.authorLe, Thuy T.pt_BR
dc.contributor.authorKaiserman, Dionpt_BR
dc.contributor.authorRowe, Caitlinpt_BR
dc.contributor.authorProw, Natalie A.pt_BR
dc.contributor.authorBarboza, Diego Damascopt_BR
dc.contributor.authorSantos, Cliomar A.pt_BR
dc.contributor.authorZanotto, Paolo M. A.pt_BR
dc.contributor.authorMagalhães, Kelly G.pt_BR
dc.contributor.authorAurelio, Luigipt_BR
dc.contributor.authorMuller, Davidpt_BR
dc.contributor.authorYoung, Paulpt_BR
dc.contributor.authorZhao, Peishenpt_BR
dc.contributor.authorBird, Phillip I.pt_BR
dc.contributor.authorSuhrbier, Andreaspt_BR
dc.date.accessioned2020-11-27T19:50:40Z-
dc.date.available2020-11-27T19:50:40Z-
dc.date.issued2020-
dc.identifier.citationSchanoski AS, Le TT., Kaiserman D, Rowe C, Prow NA., Barboza DD, et al. Granzyme a in chikungunya and other arboviral infections. Front. Immunol.. 2020 Jan;10:3083. doi:10.3389/fimmu.2019.03083.pt_BR
dc.identifier.issn1664-3224-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3314-
dc.description.abstractGranzyme A (GzmA) is secreted by cytotoxic lymphocytes and has traditionally been viewed as a mediator of cell death. However, a growing body of data suggests the physiological role of GzmA is promotion of inflammation. Here, we show that GzmA is significantly elevated in the sera of chikungunya virus (CHIKV) patients and that GzmA levels correlated with viral loads and disease scores in these patients. Serum GzmA levels were also elevated in CHIKV mouse models, with NK cells the likely source. Infection of mice deficient in type I interferon responses with CHIKV, Zika virus, or dengue virus resulted in high levels of circulating GzmA. We also show that subcutaneous injection of enzymically active recombinant mouse GzmA was able to mediate inflammation, both locally at the injection site as well as at a distant site. Protease activated receptors (PARs) may represent targets for GzmA, and we show that treatment with PAR antagonist ameliorated GzmA- and CHIKV-mediated inflammation.pt_BR
dc.description.sponsorshipFundação Butantanpt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Apoio à Pesquisa do Distrito Federal (FAPDF)pt_BR
dc.description.sponsorshipNational Health and Medical Research Council (NHMRC)pt_BR
dc.format.extent3083pt_BR
dc.languageengpt_BR
dc.publisherFrontiers Research Foundationpt_BR
dc.relation.ispartofFrontiers in Immunologypt_BR
dc.rightsOpen Accesspt_BR
dc.titleGranzyme a in chikungunya and other arboviral infections [DELETAR]pt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3389/fimmu.2019.03083pt_BR
dc.identifier.urlhttps://doi.org/10.3389/fimmu.2019.03083pt_BR
dc.contributor.externalQIMR Berghofer Medical Research Institutept_BR
dc.contributor.externalMonash Universitypt_BR
dc.contributor.externalUniversity of Queensland (UQ)pt_BR
dc.contributor.externalFundação de Saúde Parreiras Horta (FSPH)pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.contributor.externalUniversidade de Brasília (UNB)pt_BR
dc.publisher.cityLausannept_BR
dc.identifier.citationvolume10pt_BR
dc.subject.keywordchikungunyapt_BR
dc.subject.keywordgranzyme Apt_BR
dc.subject.keywordNK cellpt_BR
dc.subject.keywordarthritispt_BR
dc.subject.keywordarboviruspt_BR
dc.relation.ispartofabbreviatedFront. Immunol.pt_BR
dc.identifier.citationabntv. 10, 3083, jan. 2020pt_BR
dc.identifier.citationvancouver2020 Jan;10:3083pt_BR
dc.publisher.countrySwitzerlandpt_BR
dc.contributor.butantanSchanoski, Alessandra Soares|:Pesquisador|:Laboratório de Bacteriologia|:Autor de correspondênciapt_BR
dc.contributor.butantanBarboza, Diego Damasco|:Aluno|:Laboratório de Bacteriologiapt_BR
dc.sponsorship.butantanFundação Butantan¦¦pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦443371/2016-4pt_BR
dc.sponsorship.butantanFundação de Apoio à Pesquisa do Distrito Federal (FAPDF)¦¦193.001.621/2016pt_BR
dc.sponsorship.butantanNational Health and Medical Research Council (NHMRC)¦¦APP1078468pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
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