Stem cell-derived exosomes as therapeutic approach for neurodegenerative disorders: from biology to biotechnology

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dc.contributorLaboratório de Genéticapt_BR
dc.contributor.authorAraldi, Rodrigo Pinheiropt_BR
dc.contributor.authorD’Amélio, Fernandapt_BR
dc.contributor.authorBarros, Hugo Vigerelli dept_BR
dc.contributor.authorMelo, Thatiana Correa dept_BR
dc.contributor.authorKerkis, Irinapt_BR
dc.date.accessioned2020-12-18T18:26:06Z-
dc.date.available2020-12-18T18:26:06Z-
dc.date.issued2020-
dc.identifier.citationAraldi RP, D’Amélio F, Barros HV, Melo TC, Kerkis I. Stem cell-derived exosomes as therapeutic approach for neurodegenerative disorders: from biology to biotechnology. Cells. 2020 Dec;9(12):2663. doi:10.3390/cells9122663.pt_BR
dc.identifier.issn2073-4409-
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3415-
dc.description.abstractThe aging population has contributed to the rapid rise in the global incidence of neurodegenerative diseases. Despite the medical advances, there are no effective treatments for these disorders. Therefore, there is an urgent need for new treatments for these diseases. In this sense, cell therapy has been recognized as the best candidate for treating incurable diseases, such as neurodegenerative disorders. However, the therapeutic use of these cells can be limited by several factors. Thus, there has been a rediscovery that extracellular vesicles, including exosomes, can be alternatively explored in the treatment of these diseases, overcoming the limits of cell-based therapy. In this sense, this review aims to revisit all areas from biology, including biogenesis and the content of exosomes, to biotechnology, proposing the minimal information required to isolate, characterize, and study the content of these vesicles for scientific and/or clinical purposes.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação Butantanpt_BR
dc.format.extent2663pt_BR
dc.languageengpt_BR
dc.publisherMDPIpt_BR
dc.relation.ispartofCellspt_BR
dc.rightsOpen Accesspt_BR
dc.titleStem cell-derived exosomes as therapeutic approach for neurodegenerative disorderspt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/cells9122663pt_BR
dc.identifier.urlhttps://doi.org/10.3390/cells9122663pt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)pt_BR
dc.title.subfrom biology to biotechnologypt_BR
dc.publisher.cityBaselpt_BR
dc.identifier.citationvolume9pt_BR
dc.identifier.citationissue12pt_BR
dc.subject.keywordneurodegenerative diseasespt_BR
dc.subject.keywordextracellular vesiclespt_BR
dc.subject.keywordexosomespt_BR
dc.subject.keywordstem cellpt_BR
dc.subject.keywordcell-free therapypt_BR
dc.relation.ispartofabbreviatedCellspt_BR
dc.identifier.citationabntv. 9, n. 12, 2663, dez. 2020pt_BR
dc.identifier.citationvancouver2020 Dec;9(12):2663pt_BR
dc.publisher.countrySwitzerlandpt_BR
dc.contributor.butantanAraldi, Rodrigo Pinheiro|:Aluno|:Laboratório de Genética|:PrimeiroAutorpt_BR
dc.contributor.butantanD’Amélio, Fernanda|:Aluno|:Laboratório de Genéticapt_BR
dc.contributor.butantanVigerelli, Hugo|:Aluno:Docente colaborador PPGTOX |:Laboratório de Genéticapt_BR
dc.contributor.butantanMelo, Thatiana Correa de|:Aluno|:Laboratório de Genéticapt_BR
dc.contributor.butantanKerkis, Irina|:Pesquisador:Docente permanente PPGTOX|:Laboratório de Genética|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2017/4849-7pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦10/51051-6pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦408037/2018-0pt_BR
dc.sponsorship.butantanFundação Butantan¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
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