Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease

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dc.contributorLaboratório de Imunoquímicapt_BR
dc.contributorLaboratório de Desenvolvimento e Inovaçãopt_BR
dc.contributorCentro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)pt_BR
dc.contributorLaboratório Especial de Toxinologia Aplicada (LETA)pt_BR
dc.contributor.authorTambourgi, Denise Vilarinhopt_BR
dc.contributor.authorSquaiella-Baptistão, Carla Cristinapt_BR
dc.contributor.authorVillas-Boas, Isadora Mariapt_BR
dc.contributor.authorPidde-Queiroz, Giselept_BR
dc.contributor.authorPaes-Leme, Adriana F.pt_BR
dc.contributor.authorMarques-Porto, Rafaelpt_BR
dc.contributor.authorNishiyama Junior, Milton Yutakapt_BR
dc.contributor.authorOliveira, Ursula Castropt_BR
dc.contributor.authorJunqueira-de-Azevedo, Inácio de Loiola Meirellespt_BR
dc.date.accessioned2021-01-27T17:11:39Z-
dc.date.available2021-01-27T17:11:39Z-
dc.date.issued2021-
dc.identifier.citationTambourgi DV, Squaiella-Baptistão CC, Villas-Boas IM, Pidde-Queiroz G, Paes-Leme AF., Marques-Porto R, et al. Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease. Sci Rep. 2021 Jan;11:1995. doi:10.1038/s41598-020-79769-y.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3484-
dc.description.abstractThe joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa. The chronic inflammatory process narrows the joint space and causes alterations in bone structure and cartilage degeneration, leading to joint stiffness. Aiming to determine the bristle components that could be responsible for this peculiar envenomation, in this work we have examined the toxin composition of the caterpillar bristles extract and compared it with the differentially expressed genes (DEGs) in synovial biopsies of patients affected with rheumatoid arthritis (RA) and osteoarthritis (OA). Among the proteins identified, 129 presented an average of 63% homology with human proteins and shared important conserved domains. Among the human homologous proteins, we identified seven DEGs upregulated in synovial biopsies from RA or OA patients using meta-analysis. This approach allowed us to suggest possible toxins from the pararama bristles that could be responsible for starting the joint disease observed in pararamosis. Moreover, the study of pararamosis, in turn, may lead to the discovery of specific pharmacological targets related to the early stages of articular diseases.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent1995pt_BR
dc.languageengpt_BR
dc.relation.ispartofScientific Reportspt_BR
dc.rightsOpen Accesspt_BR
dc.titleIntegrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint diseasept_BR
dc.typeArticlept_BR
dc.identifier.doi10.1038/s41598-020-79769-ypt_BR
dc.identifier.urlhttps://doi.org/10.1038/s41598-020-79769-ypt_BR
dc.contributor.externalCentro Nacional de Pesquisa em Energia e Materiais (CNPEM)pt_BR
dc.identifier.citationvolume11pt_BR
dc.relation.ispartofabbreviatedSci Reppt_BR
dc.identifier.citationabntv. 11, 1995, jan. 2021pt_BR
dc.identifier.citationvancouver2021 Jan;11:1995pt_BR
dc.contributor.butantanPidde-Queroz, Gisele|:Pesquisador|:Laboratório de Imunoquímica|:Primeiro autor|:Autor de correspondênciapt_BR
dc.contributor.butantanNishiyama Junior, Milton Yutaka|:Pesquisador|:Laboratório Especial de Toxinologia Aplicada (LETA)|:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)pt_BR
dc.contributor.butantanOliveira, Ursula Castro|:Aluno|:|:Laboratório Especial de Toxinologia Aplicada (LETA)|:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)pt_BR
dc.contributor.butantanVillas-Boas, Isadora Maria|:Aluno|:Laboratório de Imunoquímicapt_BR
dc.contributor.butantanJunqueira-de-Azevedo, Inácio de Loiola Meirelles|:Pesquisador:Docente Permanente PPGTOX|:Laboratório Especial de Toxinologia Aplicada (LETA):Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)pt_BR
dc.contributor.butantanMarques-Porto, Rafael|:Técnico|:Laboratório de Desenvolvimento e Inovaçãopt_BR
dc.contributor.butantanSquaiella-Baptistão, Carla Cristina|:Pesquisador|:Laboratório de Imunoquímicapt_BR
dc.contributor.butantanTambourgi, Denise Vilarinho|:Pesquisador:Docente Permanente PPGTOX|:Laboratório de Imunoquímica|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467-1pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦23038.000814/2011-83pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/50040-4pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq¦)¦01358/2017-6pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
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