Serine protease autotransporters of Enterobacteriaceae (SPATEs) are largely distributed among Escherichia coli isolated from the bloodstream [DELETAR]

Full metadata record
DC FieldValueLanguage
dc.contributorLaboratório de Bacteriologiapt_BR
dc.contributor.authorElias, Waldir Pereirapt_BR
dc.contributor.authorFreire, Claudia Andradept_BR
dc.contributor.authorSantos, Ana Carolina M.pt_BR
dc.contributor.authorSilva, Rosa M.pt_BR
dc.contributor.authorPignatari, Antonio C.pt_BR
dc.date.accessioned2021-02-02T16:40:44Z-
dc.date.available2021-02-02T16:40:44Z-
dc.date.issued2020pt_BR
dc.identifier.citationElias WP, Freire CA, Santos ACM., Silva RM., Pignatari AC.. Serine protease autotransporters of Enterobacteriaceae (SPATEs) are largely distributed among Escherichia coli isolated from the bloodstream. Braz J Microbiol. 2020 Jan;51: 447–454. doi:10.1007/s42770-020-00224-1.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3502-
dc.description.abstractExtraintestinal pathogenic Escherichia coli (ExPEC) is the major cause of Gram-negative-related sepsis. Bacterial survival in the bloodstream is mediated by a variety of virulence traits, including those mediating immune system evasion. Serine protease autotransporters of Enterobacteriaceae (SPATE) constitute a superfamily of virulence factors that can cause tissue damage and cleavage of molecules of the complement system, which is a key feature for the establishment of infection in the bloodstream. In this study, we analyzed 278 E. coli strains isolated from human bacteremia from inpatients of both genders, different ages, and clinical conditions. These strains were screened for the presence of SPATE-encoding genes as well as for phylogenetic classification and intrinsic virulence of ExPEC. SPATE-encoding genes were detected in 61.2% of the strains and most of these strains (44.6%) presented distinct SPATE-encoding gene profiles. sat was the most frequent gene among the entire collection, found in 34.2%, followed by vat (28.4%), pic (8.3%), and tsh (4.7%). Although in low frequencies, espC (0.7%), eatA (1.1%), and espI (1.1%) were detected and are being reported for the first time in extraintestinal isolates. The presence of SPATE-encoding genes was positively associated to phylogroup B2 and intrinsic virulent strains. These findings suggest that SPATEs are highly prevalent and involved in diverse steps of the pathogenesis of bacteremia caused by E. coli.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent447–454pt_BR
dc.languageengpt_BR
dc.relation.ispartofBrazilian Journal of Microbiologypt_BR
dc.titleSerine protease autotransporters of Enterobacteriaceae (SPATEs) are largely distributed among Escherichia coli isolated from the bloodstream [DELETAR]pt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1007/s42770-020-00224-1pt_BR
dc.identifier.urlhttps://doi.org/10.1007/s42770-020-00224-1pt_BR
dc.contributor.externalUniversidade Federal de São Paulo (UNIFESP)pt_BR
dc.identifier.citationvolume51pt_BR
dc.subject.keywordSPATE;pt_BR
dc.subject.keywordVirulence factors;pt_BR
dc.subject.keywordEscherichia coli;pt_BR
dc.subject.keywordBacteremia;pt_BR
dc.relation.ispartofabbreviatedBraz J Microbiolpt_BR
dc.identifier.citationabntv. 51, p. 447–454, jan. 2020pt_BR
dc.identifier.citationvancouver2020 Jan;51: 447–454pt_BR
dc.contributor.butantanElias, Waldir Pereira|:Pesquisador|:Laboratório de Bacteriologia|:PrimeiroAutor|:Autor de correspondênciapt_BR
dc.contributor.butantanFreire, Claudia Andrade|:Aluno|:Laboratório de Bacteriologiapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2011/14103-0pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦142053/2015-5pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
item.fulltextSem Texto completo-
item.grantfulltextnone-
crisitem.journal.journalissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.journal.journaleissn#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.dept#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
Appears in Collections:Artigos de periódicos

Show simple item record

The access to the publications deposited in this repository respects the licenses from journals and publishers.