Extensive genomic reshuffling involved in the karyotype evolution of genus Cerradomys (Rodentia: Sigmodontinae: Oryzomyini) [DELETAR]

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dc.contributorLaboratório de Ecologia e Evolução (LEEV)pt_BR
dc.contributor.authorDi-Nizo, Camilla Brunopt_BR
dc.contributor.authorFerguson-Smith, Malcolm Andrewpt_BR
dc.contributor.authorSilva, Maria José De Jesuspt_BR
dc.date.accessioned2021-02-03T12:25:28Z-
dc.date.available2021-02-03T12:25:28Z-
dc.date.issued2020pt_BR
dc.identifier.citationDi-Nizo CB, Ferguson-Smith MA, Silva MJDJ. Extensive genomic reshuffling involved in the karyotype evolution of genus Cerradomys (Rodentia: Sigmodontinae: Oryzomyini). Genet Mol Biol. 2020 Nov;43(4):e20200149. doi:10.1590/1678-4685-gmb-2020-0149.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3506-
dc.description.abstractRodents of the genus Cerradomys belong to the tribe Oryzomyini and present high chromosome variability with diploid numbers ranging from 2n=46 to 60. Classical cytogenetics and fluorescence in situ hybridization (FISH) with telomeric and whole chromosome-specific probes of another Oryzomyini, Oligoryzomys moojeni (OMO), were used to assess the karyotype evolution of the genus. Results were integrated into a molecular phylogeny to infer the hypothetical direction of chromosome changes. The telomeric FISH showed signals in telomeres in species that diverged early in the phylogeny, plus interstitial telomeric signals (ITS) in some species from the most derived clades (C. langguthi, C. vivoi, C. goytaca, and C. subflavus). Chromosome painting revealed homology from 23 segments of C. maracajuensis and C. marinhus to 32 of C. vivoi. Extensive chromosome reorganization was responsible for karyotypic differences in closely related species. Major drivers for genomic reshuffling were in tandem and centric fusion, fission, paracentric and pericentric inversions or centromere repositioning. Chromosome evolution was associated with an increase and decrease in diploid number in different lineages and ITS indicate remnants of ancient telomeres. Cytogenetics results corroborates that C. goytaca is not a junior synonym of C. subflavus since the karyotypic differences found may lead to reproductive isolation.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipWellcome Trustpt_BR
dc.format.extente20200149pt_BR
dc.languageengpt_BR
dc.relation.ispartofGenetics and Molecular Biologypt_BR
dc.rightsOpen Accesspt_BR
dc.titleExtensive genomic reshuffling involved in the karyotype evolution of genus Cerradomys (Rodentia: Sigmodontinae: Oryzomyini) [DELETAR]pt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1590/1678-4685-gmb-2020-0149pt_BR
dc.identifier.urlhttps://doi.org/10.1590/1678-4685-gmb-2020-0149pt_BR
dc.contributor.externalUniversity of Cambridgept_BR
dc.identifier.citationvolume43pt_BR
dc.identifier.citationissue4pt_BR
dc.subject.keywordChromosomal evolutionpt_BR
dc.subject.keywordGTG-bandingpt_BR
dc.subject.keywordOryzomyinipt_BR
dc.subject.keywordZOO-FISHpt_BR
dc.relation.ispartofabbreviatedGenet Mol Biolpt_BR
dc.identifier.citationabntv. 43, n. 4, e20200149, nov. 2020pt_BR
dc.identifier.citationvancouver2020 Nov;43(4):e20200149pt_BR
dc.contributor.butantanDi-Nizo, Camilla Bruno|:Aluno|:Laboratório de Ecologia e Evolução (LEEV)|:PrimeiroAutor|:Autor de correspondênciapt_BR
dc.contributor.butantanSilva, Maria José De Jesus|:Pesquisador|:Laboratório de Ecologia e Evolução (LEEV)pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦001pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2014/02885-2pt_BR
dc.sponsorship.butantanWellcome Trust¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
item.openairetypeArticle-
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item.grantfulltextembargo_29990101-
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