Encrypted antimicrobial peptides from proteins present in the plasma of the millipede Rhinocricus sp.

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dc.contributorLETA - Laboratório de Toxinologia Aplicadapt_BR
dc.contributorLCC - Laboratório de Ciclo Celularpt_BR
dc.contributor.authorSegura Ramirez, Paula Jimenapt_BR
dc.contributor.authorGodoy, Pedro Machado dept_BR
dc.contributor.authorAvino, Ivan Novaskipt_BR
dc.contributor.authorSilva Junior, Pedro Ismael dapt_BR
dc.date.accessioned2021-04-26T14:46:28Z-
dc.date.available2021-04-26T14:46:28Z-
dc.date.issued2021pt_BR
dc.identifier.citationSegura Ramirez PJ, Silva Junior PI. Encrypted antimicrobial peptides from proteins present in the plasma of the millipede Rhinocricus sp.. J Proteomics. 2021 apr;242:104239. doi:10.1016/j.jprot.2021.104239.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3682-
dc.description.abstractMillipedes are among the most diverse and abundant arthropods in terrestrial environments. However, little is known about their innate immune response against invading pathogenic microorganisms, which is very intriguing considering that the evolutionary success of millipedes is largely due to this complex and primitive defense system, since it allowed them to colonize a wide variety of microhabitats characterized by their high microbial proliferation. Accordingly, the aim of the present work was to determine the presence of antimicrobial peptides in the hemolymph of the millipede Rhinocricus sp. in total, four native peptides with potent antimicrobial activity against different microorganisms, lack of cytotoxicity against Vero cells and lack of hemolytic effects against human erythrocytes were isolated and named RP40–16, RP40–19, RP40–20/1 and RP40–20/2. The analysis with bioinformatics tools suggested that these peptides may be encrypted in large proteins present in the plasma: Hemocyanin and thioester-containing protein. Considering these results, it can be said that millipede hemolymph represents a promising source of molecules with potential for the development of non-conventional antibiotics. Therefore, in order to have a clearer notion of the biotechnological potential and the role of these peptides in the innate immune response of Rhinocricus sp., future studies should focus on elucidating their mechanisms of action, as well as additional biological propertiespt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent104239pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofJournal of Proteomicspt_BR
dc.rightsRestricted Accesspt_BR
dc.titleEncrypted antimicrobial peptides from proteins present in the plasma of the millipede Rhinocricus sp.pt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.jprot.2021.104239pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.jprot.2021.104239pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.identifier.citationvolume242pt_BR
dc.subject.keywordInnate immunitypt_BR
dc.subject.keywordAntimicrobial peptidept_BR
dc.subject.keywordPlasmapt_BR
dc.subject.keywordMillipedept_BR
dc.subject.keywordRhinocricuspt_BR
dc.relation.ispartofabbreviatedJ Proteomicspt_BR
dc.identifier.citationabntv. 242, 104239, apr. 2021pt_BR
dc.identifier.citationvancouver2021 apr;242:104239pt_BR
dc.contributor.butantanSegura Ramirez, Paula Jimena|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA)|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanGodoy, Pedro Machado de|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA)pt_BR
dc.contributor.butantanAvino, Ivan Novaski|:Técnico|:LCC - Laboratório de Ciclo Celularpt_BR
dc.contributor.butantanSilva Junior, Pedro Ismael da|:Pesquisador|:Laboratório Especial de Toxinologia Aplicada (LETA)|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467-1pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦72744/2012-7pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦90529/2017-2]¦¦190529/2017-2pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
item.fulltextCom Texto completo-
item.grantfulltextembargo_29990101-
item.languageiso639-1English-
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