Sphingomyelinase D activity in Sicarius Tropicus Venom: toxic potential and clues to the evolution of SMases D in the Sicariidae family

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dc.contributorLab. Imunoquímicapt_BR
dc.contributorLEEV - Laboratório de Ecologia e Evoluçãopt_BR
dc.contributor.authorLopes, Priscila Hesspt_BR
dc.contributor.authorFukushima, Caroline Sayuript_BR
dc.contributor.authorShoji, Rosana de Fátimapt_BR
dc.contributor.authorBertani, Rogériopt_BR
dc.contributor.authorTambourgi, Denise Vilarinhopt_BR
dc.date.accessioned2021-05-04T20:01:33Z-
dc.date.available2021-05-04T20:01:33Z-
dc.date.issued2021pt_BR
dc.identifier.citationLopes PH, Fukushima CS, Shoji RF, Bertani R, Tambourgi DV. Sphingomyelinase D activity in Sicarius Tropicus Venom: toxic potential and clues to the evolution of SMases D in the Sicariidae family. Toxins. 2021 Apr;13(4):256. doi:10.3390/toxins13040256.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3696-
dc.description.abstractThe spider family Sicariidae includes three genera, Hexophthalma, Sicarius and Loxosceles. The three genera share a common characteristic in their venoms: the presence of Sphingomyelinases D (SMase D). SMases D are considered the toxins that cause the main pathological effects of the Loxosceles venom, that is, those responsible for the development of loxoscelism. Some studies have shown that Sicarius spiders have less or undetectable SMase D activity in their venoms, when compared to Hexophthalma. In contrast, our group has shown that Sicarius ornatus, a Brazilian species, has active SMase D and toxic potential to envenomation. However, few species of Sicarius have been characterized for their toxic potential. In order to contribute to a better understanding about the toxicity of Sicarius venoms, the aim of this study was to characterize the toxic properties of male and female venoms from Sicarius tropicus and compare them with that from Loxosceles laeta, one of the most toxic Loxosceles venoms. We show here that S. tropicus venom presents active SMases D. However, regarding hemolysis development, it seems that these toxins in this species present different molecular mechanisms of action than that described for Loxosceles venoms, whereas it is similar to those present in bacteria containing SMase D. Besides, our results also suggest that, in addition to the interspecific differences, intraspecific variations in the venoms’ composition may play a role in the toxic potential of venoms from Sicarius species.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipKone Foundationpt_BR
dc.format.extent256pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofToxinspt_BR
dc.rightsOpen Accesspt_BR
dc.titleSphingomyelinase D activity in Sicarius Tropicus Venom: toxic potential and clues to the evolution of SMases D in the Sicariidae familypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/toxins13040256pt_BR
dc.identifier.urlhttps://doi.org/10.3390/toxins13040256pt_BR
dc.contributor.externalUniversity of Helsinkipt_BR
dc.identifier.citationvolume13pt_BR
dc.identifier.citationissue4pt_BR
dc.subject.keywordSicariuspt_BR
dc.subject.keywordLoxoscelespt_BR
dc.subject.keywordspiderspt_BR
dc.subject.keywordsphingomyelinase Dpt_BR
dc.subject.keywordhemolysispt_BR
dc.subject.keywordvenoms variationspt_BR
dc.relation.ispartofabbreviatedToxinspt_BR
dc.identifier.citationabntv. 13, n. 4, 256, abr. 2021pt_BR
dc.identifier.citationvancouver2021 Apr;13(4):256pt_BR
dc.contributor.butantanLopes, Priscila Hess|:Aluno|:Lab. Imunoquímica|:PrimeiroAutorpt_BR
dc.contributor.butantanFukushima, Caroline Sayuri|:Aluno|:LEEV - Laboratório de Ecologia e Evoluçãopt_BR
dc.contributor.butantanShoji, Rosana de Fátima|:Técnico|:Lab. Imunoquímicapt_BR
dc.contributor.butantanBertani, Rogério|:Pesquisador|:LEEV - Laboratório de Ecologia e Evoluçãopt_BR
dc.contributor.butantanTambourgi, Denise Vilarinho|:Pesquisador:Docente Permanente PPGTOX|:Lab. Imunoquímica|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/17053-5pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦301358/2017-6pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦307704/2017-3pt_BR
dc.sponsorship.butantanCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)¦¦23038.00814/2011-83pt_BR
dc.sponsorship.butantanKone Foundation¦¦2018pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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