Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome

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dc.contributorLETA - Laboratório de Toxinologia Aplicadapt_BR
dc.contributorCentro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)pt_BR
dc.contributorLab. Imunopatologiapt_BR
dc.contributorLab. Bacteriologiapt_BR
dc.contributor.authorAlmeida, Diego Dantaspt_BR
dc.contributor.authorViala, Vincent Louispt_BR
dc.contributor.authorNachtigall, Pedro Gabrielpt_BR
dc.contributor.authorBroe, Michaelpt_BR
dc.contributor.authorGibbs, H. Lislept_BR
dc.contributor.authorSerrano, Solange Maria de Toledopt_BR
dc.contributor.authorMoura-da-Silva, Ana Mariapt_BR
dc.contributor.authorHo, Paulo Leept_BR
dc.contributor.authorNishiyama Junior, Milton Yutakapt_BR
dc.contributor.authorJunqueira-de-Azevedo, Inácio de Loiola Meirellespt_BR
dc.date.accessioned2021-05-14T19:26:37Z-
dc.date.available2021-05-14T19:26:37Z-
dc.date.issued2021pt_BR
dc.identifier.citationAlmeida DD, Viala VL, Nachtigall PG, Broe M, Gibbs H.L, Serrano SMT, et al. Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome. Proc Natl Acad Sci U S A. 2021 Apr;118(20):e2015159118. doi:10.1073/pnas.2015159118.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3732-
dc.description.abstractVenom is a key adaptive innovation in snakes, and how nonvenom genes were co-opted to become part of the toxin arsenal is a significant evolutionary question. While this process has been investigated through the phylogenetic reconstruction of toxin sequences, evidence provided by the genomic context of toxin genes remains less explored. To investigate the process of toxin recruitment, we sequenced the genome of Bothrops jararaca, a clinically relevant pitviper. In addition to producing a road map with canonical structures of genes encoding 12 toxin families, we inferred most of the ancestral genes for their loci. We found evidence that 1) snake venom metalloproteinases (SVMPs) and phospholipases A2 (PLA2) have expanded in genomic proximity to their nonvenomous ancestors; 2) serine proteinases arose by co-opting a local gene that also gave rise to lizard gilatoxins and then expanded; 3) the bradykinin-potentiating peptides originated from a C-type natriuretic peptide gene backbone; and 4) VEGF-F was co-opted from a PGF-like gene and not from VEGF-A. We evaluated two scenarios for the original recruitment of nontoxin genes for snake venom: 1) in locus ancestral gene duplication and 2) in locus ancestral gene direct co-option. The first explains the origins of two important toxins (SVMP and PLA2), while the second explains the emergence of a greater number of venom components. Overall, our results support the idea of a locally assembled venom arsenal in which the most clinically relevant toxin families expanded through posterior gene duplications, regardless of whether they originated by duplication or gene co-optionpt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipNational Science Foundation (NSF)pt_BR
dc.format.extente2015159118pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americapt_BR
dc.rightsRestricted Accesspt_BR
dc.titleTracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genomept_BR
dc.typeArticlept_BR
dc.identifier.doi10.1073/pnas.2015159118pt_BR
dc.identifier.urlhttps://doi.org/10.1073/pnas.2015159118pt_BR
dc.contributor.externalOhio State Universitypt_BR
dc.contributor.externalUniversidade do Estado do Amazonas (UEA)pt_BR
dc.identifier.citationvolume118pt_BR
dc.identifier.citationissue20pt_BR
dc.subject.keywordsnake venompt_BR
dc.subject.keywordtoxin evolutionpt_BR
dc.subject.keywordgenomept_BR
dc.subject.keywordgene recruitmentpt_BR
dc.subject.keywordco-optionpt_BR
dc.relation.ispartofabbreviatedProc Natl Acad Sci U S Apt_BR
dc.identifier.citationabntv. 118, n. 20, e2015159118, abr. 2021pt_BR
dc.identifier.citationvancouver2021 Apr;118(20):e2015159118pt_BR
dc.contributor.butantanAlmeida, Diego Dantas|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA):Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)|:PrimeiroAutorpt_BR
dc.contributor.butantanViala, Vincent Louis|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA):Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)pt_BR
dc.contributor.butantanNachtigall, Pedro Gabriel|:Aluno|:Laboratório Especial de Toxinologia Aplicada (LETA):Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)|:PrimeiroAutor:Autor de correspondênciapt_BR
dc.contributor.butantanSerrano, Solange Maria de Toledo|:Pesquisador:Docente permanente PPGTOX|:Laboratório Especial de Toxinologia Aplicada (LETA)|:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)pt_BR
dc.contributor.butantanMoura-da-Silva, Ana Maria|:Pesquisador:Docente permanente PPGTOX|:Lab. Imunopatologiapt_BR
dc.contributor.butantanHo, Paulo Lee|:Pesquisador|:Lab. Bacteriologiapt_BR
dc.contributor.butantanNishiyama Junior, Milton Yutaka|:Pesquisador|:Laboratório Especial de Toxinologia Aplicada (LETA)|:Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)pt_BR
dc.contributor.butantanJunqueira-de-Azevedo, Inácio de Loiola Meirelles|:Pesquisador|:Laboratório Especial de Toxinologia Aplicada (LETA):Centro de Toxinas, Resposta-imune e Sinalização Celular (CeTICS)|:Autor de correspondênciapt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07467-1pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2012/00177-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2016/50127-5pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2013/07964-0pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2015/03509-7pt_BR
dc.sponsorship.butantanFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)¦¦2018/26520-4pt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦304532/20134pt_BR
dc.sponsorship.butantanNational Science Foundation (NSF)¦¦1638872pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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