Effects of Kynurenic acid on the rat aorta ischemia—reperfusion model: pharmacological characterization and proteomic profiling

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dc.contributorLab. Biofísicapt_BR
dc.contributorLab. Genéticapt_BR
dc.contributor.authorLima, Viviane Soares Souzapt_BR
dc.contributor.authorMariano, Douglas Oscar Ceolinpt_BR
dc.contributor.authorVigerelli, Hugopt_BR
dc.contributor.authorJanussi, Sabrina Cardosopt_BR
dc.contributor.authorBaptista, Thayz Vanalli Limapt_BR
dc.contributor.authorClaudino, Mário Angelopt_BR
dc.contributor.authorPimenta, Daniel Carvalhopt_BR
dc.contributor.authorSciani, Juliana Mozerpt_BR
dc.date.accessioned2021-06-04T18:15:58Z-
dc.date.available2021-06-04T18:15:58Z-
dc.date.issued2021pt_BR
dc.identifier.citationLima VSS, Mariano DOC, Vigerelli H, Janussi SC, Baptista TVL, Claudino MA, et al. Effects of Kynurenic acid on the Rat Aorta Ischemia—Reperfusion model: pharmacological characterization and proteomic profiling. Molecules. 2021 May;26(10):2845. doi:10.3390/molecules26102845.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3818-
dc.description.abstractKynurenic acid (KYNA) is derived from tryptophan, formed by the kynurenic pathway. KYNA is being widely studied as a biomarker for neurological and cardiovascular diseases, as it is found in ischemic conditions as a protective agent; however, little is known about its effect after ischemia-reperfusion in the vascular system. We induced ischemia for 30 min followed by 5 min reperfusion (I/R) in the rat aorta for KYNA evaluation using functional assays combined with proteomics. KYNA recovered the exacerbated contraction induced by phenylephrine and relaxation induced by acetylcholine or sodium nitroprussiate in the I/R aorta, with vessel responses returning to values observed without I/R. The functional recovery can be related to the antioxidant activity of KYNA, which may be acting on the endothelium-injury prevention, especially during reperfusion, and to proteins that regulate neurotransmission and cell repair/growth, expressed after the KYNA treatment. These proteins interacted in a network, confirming a protein profile expression for endothelium and neuron repair after I/R. Thus, the KYNA treatment had the ability to recover the functionality of injured ischemic-reperfusion aorta, by tissue repairing and control of neurotransmitter release, which reinforces its role in the post-ischemic condition, and can be useful in the treatment of such diseasept_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.format.extent2845pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofMoleculespt_BR
dc.rightsOpen Accesspt_BR
dc.titleEffects of Kynurenic acid on the rat aorta ischemia—reperfusion model: pharmacological characterization and proteomic profilingpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.3390/molecules26102845pt_BR
dc.identifier.urlhttps://doi.org/10.3390/molecules26102845pt_BR
dc.contributor.externalUniversidade São Francisco (USF)pt_BR
dc.identifier.citationvolume26pt_BR
dc.identifier.citationissue10pt_BR
dc.subject.keywordkynurenic acidpt_BR
dc.subject.keywordischemia-reperfusionpt_BR
dc.subject.keywordaortapt_BR
dc.subject.keywordfunctionalitypt_BR
dc.subject.keywordproteomicspt_BR
dc.relation.ispartofabbreviatedMoleculespt_BR
dc.identifier.citationabntv. 26, n. 10, 2845, maio. 2021pt_BR
dc.identifier.citationvancouver2021 May;26(10):2845pt_BR
dc.contributor.butantanMariano, Douglas Oscar Ceolin|:Aluno|:Lab. Biofísicapt_BR
dc.contributor.butantanVigerelli, Hugo|:Pesquisador|:Lab. Genéticapt_BR
dc.contributor.butantanPimenta, Daniel Carvalho|:Pesquisador:Docente permanente PPGTOX|:Lab. Biofísicapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦301974/2019-5pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextembargo_29990101-
item.languageiso639-1English-
item.openairetypeArticle-
item.fulltextCom Texto completo-
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