
Effects of Kynurenic acid on the rat aorta ischemia—reperfusion model: pharmacological characterization and proteomic profiling
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DC Field | Value | Language |
---|---|---|
dc.contributor | Lab. Bioquímica | pt_BR |
dc.contributor | (LG) Lab. Genética | pt_BR |
dc.contributor | Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox) | pt_BR |
dc.contributor.author | Lima, Viviane Soares Souza | pt_BR |
dc.contributor.author | Mariano, Douglas Oscar Ceolin | pt_BR |
dc.contributor.author | Vigerelli, Hugo | pt_BR |
dc.contributor.author | Janussi, Sabrina Cardoso | pt_BR |
dc.contributor.author | Baptista, Thayz Vanalli Lima | pt_BR |
dc.contributor.author | Claudino, Mário Angelo | pt_BR |
dc.contributor.author | Pimenta, Daniel Carvalho | pt_BR |
dc.contributor.author | Sciani, Juliana Mozer | pt_BR |
dc.date.accessioned | 2021-06-04T18:15:58Z | - |
dc.date.available | 2021-06-04T18:15:58Z | - |
dc.date.issued | 2021 | pt_BR |
dc.identifier.citation | Lima VSS, Mariano DOC, Vigerelli H, Janussi SC, Baptista TVL, Claudino MA, et al. Effects of Kynurenic acid on the Rat Aorta Ischemia—Reperfusion model: pharmacological characterization and proteomic profiling. Molecules. 2021 May;26(10):2845. doi:10.3390/molecules26102845. | pt_BR |
dc.identifier.uri | https://repositorio.butantan.gov.br/handle/butantan/3818 | - |
dc.description.abstract | Kynurenic acid (KYNA) is derived from tryptophan, formed by the kynurenic pathway. KYNA is being widely studied as a biomarker for neurological and cardiovascular diseases, as it is found in ischemic conditions as a protective agent; however, little is known about its effect after ischemia-reperfusion in the vascular system. We induced ischemia for 30 min followed by 5 min reperfusion (I/R) in the rat aorta for KYNA evaluation using functional assays combined with proteomics. KYNA recovered the exacerbated contraction induced by phenylephrine and relaxation induced by acetylcholine or sodium nitroprussiate in the I/R aorta, with vessel responses returning to values observed without I/R. The functional recovery can be related to the antioxidant activity of KYNA, which may be acting on the endothelium-injury prevention, especially during reperfusion, and to proteins that regulate neurotransmission and cell repair/growth, expressed after the KYNA treatment. These proteins interacted in a network, confirming a protein profile expression for endothelium and neuron repair after I/R. Thus, the KYNA treatment had the ability to recover the functionality of injured ischemic-reperfusion aorta, by tissue repairing and control of neurotransmitter release, which reinforces its role in the post-ischemic condition, and can be useful in the treatment of such disease | pt_BR |
dc.description.sponsorship | (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico | pt_BR |
dc.format.extent | 2845 | pt_BR |
dc.language.iso | English | pt_BR |
dc.relation.ispartof | Molecules | pt_BR |
dc.rights | Open access | pt_BR |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | pt_BR |
dc.title | Effects of Kynurenic acid on the rat aorta ischemia—reperfusion model: pharmacological characterization and proteomic profiling | pt_BR |
dc.type | Article | pt_BR |
dc.rights.license | CC BY | pt_BR |
dc.identifier.doi | 10.3390/molecules26102845 | pt_BR |
dc.identifier.url | https://doi.org/10.3390/molecules26102845 | pt_BR |
dc.contributor.external | (USF) Universidade São Francisco | pt_BR |
dc.identifier.citationvolume | 26 | pt_BR |
dc.identifier.citationissue | 10 | pt_BR |
dc.subject.keyword | kynurenic acid | pt_BR |
dc.subject.keyword | ischemia-reperfusion | pt_BR |
dc.subject.keyword | aorta | pt_BR |
dc.subject.keyword | functionality | pt_BR |
dc.subject.keyword | proteomics | pt_BR |
dc.relation.ispartofabbreviated | Molecules | pt_BR |
dc.identifier.citationabnt | v. 26, n. 10, 2845, maio. 2021 | pt_BR |
dc.identifier.citationvancouver | 2021 May;26(10):2845 | pt_BR |
dc.contributor.butantan | Mariano, Douglas Oscar Ceolin|:Aluno Egresso|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:Lab. Bioquímica | pt_BR |
dc.contributor.butantan | Vigerelli, Hugo|:Pesquisador|:Lab. Genética | pt_BR |
dc.contributor.butantan | Pimenta, Daniel Carvalho|:Pesquisador:Docente permanente PPGTOX|:Lab. Bioquímica | pt_BR |
dc.sponsorship.butantan | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦301974/2019-5 | pt_BR |
dc.identifier.bvscc | BR78.1 | pt_BR |
dc.identifier.bvsdb | IBProd | pt_BR |
dc.description.dbindexed | Yes | pt_BR |
item.openairetype | Article | - |
item.languageiso639-1 | English | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
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