New potential antiproliferative monophosphoester 2-aminoethyl dihydrogen phosphate in K-562 and K-562 MDR+ leukemia cells

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dc.contributor(LDI) Laboratório de Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.authorConceição, Thais de Oliveirapt_BR
dc.contributor.authorCabral, Laertty Garcia de Sousapt_BR
dc.contributor.authorSilva, Manuela Garcia Laveli dapt_BR
dc.contributor.authorCarlstron, Julio Pachecopt_BR
dc.contributor.authorAlves, Monique Goncalvespt_BR
dc.contributor.authorRabelo, DC.pt_BR
dc.contributor.authorLaiso, Rosa Andréa Nogueirapt_BR
dc.contributor.authorMaria, Durvanei Augustopt_BR
dc.date.accessioned2021-09-20T15:45:28Z-
dc.date.available2021-09-20T15:45:28Z-
dc.date.issued2021pt_BR
dc.identifier.citationConceição TO, Cabral LGS, Silva MGL, Carlstron JP, Alves MG, Rabelo DC., et al. New potential antiproliferative monophosphoester 2-aminoethyl dihydrogen phosphate in K-562 and K-562 MDR+ leukemia cells. Biomed. Pharmacother.. 2021 Oct;142:112054. doi:10.1016/j.biopha.2021.112054.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3936-
dc.description.abstractThe main obstacle in the treatment of cancer patients has been resistance to multiple drugs, leading to the need to develop molecules with a higher specificity target. The liposomal formulation DODAC/2-AEH2P has antitumor potential, inducing apoptosis in several tumor types. Human chronic myeloid leukemia K-562 and K-562 Lucena (MDR+) cells were treated with the DODAC carrier and the liposomal formulation 2-AEH2P. Viability, cell cycle phases, apoptosis, marker expression and mitochondrial potential were analyzed. Significant reduction in viability was observed for all treatments. Changes in the distribution of the cell cycle phases and expression of markers involved in the apoptosis pathways were observed. Reduction of the mitochondrial electrical potential mediated by Bcl-2, being regulated by the reduction of the MTCH2 protein linked to the progression of myeloid leukemia and an increase in the pro-apoptotic proteins Bad and Bax, dependent on p53. This study demonstrated a significant therapeutic potential through apoptotic effects in leukemic cells, regardless of the molecular resistance profile (MDR+).pt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent112054pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofBiomedicine & Pharmacotherapypt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/pt_BR
dc.titleNew potential antiproliferative monophosphoester 2-aminoethyl dihydrogen phosphate in K-562 and K-562 MDR+ leukemia cellspt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BY-NC-NDpt_BR
dc.identifier.doi10.1016/j.biopha.2021.112054pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.biopha.2021.112054pt_BR
dc.contributor.externalUniversidade de São Paulo (USP)pt_BR
dc.identifier.citationvolume142pt_BR
dc.subject.keywordLeukemiapt_BR
dc.subject.keywordDrug resistancept_BR
dc.subject.keywordDODAC carrierpt_BR
dc.subject.keywordLiposomal formulationpt_BR
dc.subject.keyword2-AEH2Ppt_BR
dc.relation.ispartofabbreviatedBiomed. Pharmacother.pt_BR
dc.identifier.citationabntv. 142, 112054, out. 2021pt_BR
dc.identifier.citationvancouver2021 Oct;142:112054pt_BR
dc.contributor.butantanConceição, Thais de Oliveira|:Desvinculado|:(LDI) Laboratório de Desenvolvimento e Inovação Industrial|:PrimeiroAutorpt_BR
dc.contributor.butantanCabral, Laertty Garcia de Sousa|:Desvinculado|:(LDI) Laboratório de Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.butantanSilva, Manuela Garcia Laveli da|:Desvinculado|:(LDI) Laboratório de Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.butantanCarlstron, Julio Pacheco|:Desvinculado|:(LDI) Laboratório de Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.butantanAlves, Monique Goncalves|:Desvinculado|:(LDI) Laboratório de Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.butantanLaiso, Rosa Andréa Nogueira|:Desvinculado|:(LDI) Laboratório de Desenvolvimento e Inovação Industrialpt_BR
dc.contributor.butantanMaria, Durvanei Augusto|:Pesquisador|:(LDI) Laboratório de Desenvolvimento e Inovação Industriall|:Autor de correspondênciapt_BR
dc.sponsorship.butantanConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)¦¦305056/2019-0pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
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