COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: a single-center observational study

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dc.contributor(LEDS) Laboratório de Dor e Sinalizaçãopt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributorIniciação Científicapt_BR
dc.contributor.authorKimura, Louise Faggionatopt_BR
dc.contributor.authorSant´Anna, Morena Brazil Martinspt_BR
dc.contributor.authorChudzinski, Sonia Aparecida de Andradept_BR
dc.contributor.authorEbram, Matteo Celanopt_BR
dc.contributor.authorLima, Cristiane Ferreira Graça dept_BR
dc.contributor.authorCelano, Rosa M.G.pt_BR
dc.contributor.authorViégas, Ruy F.M.pt_BR
dc.contributor.authorPicolo, Giselept_BR
dc.date.accessioned2021-10-04T16:42:45Z-
dc.date.available2021-10-04T16:42:45Z-
dc.date.issued2021pt_BR
dc.identifier.citationKimura LF, Sant´Anna MBM, Chudzinski SAA, Ebram MC, Lima CFG, Celano RM.G., et al. COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study. Blood Cells Mol Dis. 2021 Dec;92:102604. doi:10.1016/j.bcmd.2021.102604.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3948-
dc.description.abstractPatients with COVID-19 can be asymptomatic or present mild to severe symptoms, leading to respiratory and cardiovascular complications and death. Type 2 diabetes mellitus (T2DM) and obesity are considered risk factors for COVID-19 poor prognosis. In parallel, COVID-19 severe patients exhibit dyslipidemia and alterations in neutrophil to lymphocyte ratio (NLR) associated with disease severity and mortality. To investigate whether such alterations are caused by the infection or results from preexisting comorbidities, this work analyzed dyslipidemia and the hemogram profile of COVID-19 patients according to the severity and compared with patients without T2DM or obesity comorbidities. Dyslipidemia, with a marked decrease in HDL levels, and increased NLR accompanied the disease severity, even in non-T2DM and non-obese patients, indicating that COVID-19 causes the observed alterations. Because decreased hemoglobin is involved in COVID-19 severity, and hemoglobin concentration is associated with metabolic diseases, the erythrogram of patients was also evaluated. We verified a drop in hemoglobin and erythrocyte number in severe patients, independently of T2DM and obesity, which may explain in part the need for artificial ventilation in severe cases. Thus, the control of such parameters (especially HDL levels, NLR, and hemoglobin concentration) could be a good strategy to prevent COVID-19 complications and death.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.extent102604pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofBlood cells, molecules & diseasespt_BR
dc.rightsRestricted accesspt_BR
dc.titleCOVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: a single-center observational studypt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.bcmd.2021.102604pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.bcmd.2021.102604pt_BR
dc.contributor.external(UNITAU) Universidade de Taubatépt_BR
dc.identifier.citationvolume92pt_BR
dc.subject.keywordSARS-CoV-2pt_BR
dc.subject.keywordCOVID-19pt_BR
dc.subject.keywordDyslipidemiapt_BR
dc.subject.keywordHemoglobin concentrationpt_BR
dc.subject.keywordNeutrophil to lymphocyte ratiopt_BR
dc.relation.ispartofabbreviatedBlood Cells Mol Dispt_BR
dc.identifier.citationabntv. 92, 102604, dez. 2021pt_BR
dc.identifier.citationvancouver2021 Dec;92:102604pt_BR
dc.contributor.butantanKimura, Louise Faggionato|:Aluno Egresso|:Laboratório de Dor e Sinalização:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)|:PrimeiroAutorpt_BR
dc.contributor.butantanSant´Anna, Morena Brazil Martins|:Pós-Doc|:Laboratório de Dor e Sinalização:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.butantanChudzinski, Sonia Aparecida de Andrade|:Pesquisador:Docente Colaborador PPGTox|:Laboratório de Dor e Sinalizaçãopt_BR
dc.contributor.butantanEbram, Matteo Celano|:Aluno|:Laboratório de Dor e Sinalização:Iniciação Científicapt_BR
dc.contributor.butantanLima, Cristiane Ferreira Graça de|:Aluno|:Laboratório de Dor e SinalizaçãoPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.butantanPicolo, Gisele|:Pesquisador|:Laboratório de Dor e Sinalização|:Autor de correspondênciapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/05882-8pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2013/07467-1pt_BR
dc.sponsorship.butantan(CAPES) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior¦¦001pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.grantfulltextembargo_29990101-
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item.openairetypeArticle-
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