Zebrafish as a model to study inflammation: a tool for drug discovery

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dc.contributor(LBI) Laboratório de Imunoquímicapt_BR
dc.contributor.authorBelo, Marco A.A.pt_BR
dc.contributor.authorOliveira, Melque F.pt_BR
dc.contributor.authorOliveira, Susana L.pt_BR
dc.contributor.authorAracati, Mayumi F.pt_BR
dc.contributor.authorRodrigues, Letícia F.pt_BR
dc.contributor.authorCosta, Camila C.pt_BR
dc.contributor.authorConde, Gabrielpt_BR
dc.contributor.authorGomes, Juliana M.M.pt_BR
dc.contributor.authorPrata, Mariana N.L.pt_BR
dc.contributor.authorBarra, Ayslanpt_BR
dc.contributor.authorValverde, Thalita M.pt_BR
dc.contributor.authorMelo, Daniela C. dept_BR
dc.contributor.authorEto, Silas F.pt_BR
dc.contributor.authorFernandes, Dayanne Carlapt_BR
dc.contributor.authorRomero, Marina G.M.C.pt_BR
dc.contributor.authorCorrêa Júnior, José D.pt_BR
dc.contributor.authorSilva, Juliana O.pt_BR
dc.contributor.authorBarros, Andre L.B.pt_BR
dc.contributor.authorPerez, Andrea C.pt_BR
dc.contributor.authorCharlie-Silva, Ivespt_BR
dc.date.accessioned2021-11-12T18:45:54Z-
dc.date.available2021-11-12T18:45:54Z-
dc.date.issued2021pt_BR
dc.identifier.citationBelo MA.A., Oliveira MF., Oliveira SL., Aracati MF., Rodrigues LF., Costa CC., et al. Zebrafish as a model to study inflammation: a tool for drug discovery. Biomed. Pharmacother.. 2021 Dec;144:112310. doi:10.1016/j.biopha.2021.112310.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/3975-
dc.description.abstractThis study aims to demonstrate the applicability and importance of zebrafish (Danio rerio) model to study acute and chronic inflammatory responses induced by different stimuli: carrageenan phlogogen (nonimmune); acute infection by bacteria (immune); foreign body reaction (chronic inflammation by round glass coverslip implantation); reaction induced by xenotransplantation. In addition to the advantages of presenting low breeding cost, high prolificity, transparent embryos, high number of individuals belonging to the same spawning and high genetic similarity that favor translational responses to vertebrate organisms like humans, zebrafish proved to be an excellent tool, allowing the evaluation of edema formation, accumulation of inflammatory cells in the exudate, mediators, signaling pathways, gene expression and production of specific proteins. Our studies demonstrated the versatility of fish models to investigate the inflammatory response and its pathophysiology, essential for the successful development of studies to discover innovative pharmacological strategies.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(FAPEMIG) Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent112310pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofBiomedicine & Pharmacotherapypt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/pt_BR
dc.titleZebrafish as a model to study inflammation: a tool for drug discoverypt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BY-NC-NDpt_BR
dc.identifier.doi10.1016/j.biopha.2021.112310pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.biopha.2021.112310pt_BR
dc.contributor.externalUniversidade Brasilpt_BR
dc.contributor.external(UNESP) Universidade Estadual Paulista Júlio de Mesquita Filhopt_BR
dc.contributor.external(UFMG) Universidade Federal de Minas Geraispt_BR
dc.contributor.external(UFRR) Universidade Federal de Roraimapt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.identifier.citationvolume144pt_BR
dc.subject.keywordInflammatory reactionpt_BR
dc.subject.keywordTeleost fishpt_BR
dc.subject.keywordInnate Immunitypt_BR
dc.subject.keywordAcute and chronic inflammationpt_BR
dc.subject.keywordForeign body reactionpt_BR
dc.subject.keywordXenotransplantationpt_BR
dc.relation.ispartofabbreviatedBiomed. Pharmacother.pt_BR
dc.identifier.citationabntv. 144, 112310, dez. 2021pt_BR
dc.identifier.citationvancouver2021 Dec;144:112310pt_BR
dc.contributor.butantanFernandes, Dayanne Carla|:Pós-doc|:Laboratório de Imunoquímicapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2013/25971-9pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/07098-0pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/19939-1pt_BR
dc.sponsorship.butantan(FAPEMIG) Fundação de Amparo à Pesquisa do Estado de Minas Gerais¦¦APQ-02913-17pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦477816/2013-4pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦301473 / 2016-1pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦307526/2018-6pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
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item.languageiso639-1English-
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