Genomic monitoring of the SARS-CoV-2 B1.1.7 (WHO VOC Alpha) in the Sao Paulo state, Brazil

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dc.contributorCentro Bioindustrialpt_BR
dc.contributor(LCC) Lab. Ciclo Celularpt_BR
dc.contributorLab. Bioquímicapt_BR
dc.contributor(LEDM) Lab. Estratégico de Diagnóstico Molecularpt_BR
dc.contributor(HVB) Hospital Vital Brazilpt_BR
dc.contributorDiretoria Técnicapt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorSlavov, Svetoslav Nanevpt_BR
dc.contributor.authorBezerra, Rafael dos Santospt_BR
dc.contributor.authorRodrigues, Evandra Strazzapt_BR
dc.contributor.authorLima, Alex Ranieri Jerônimopt_BR
dc.contributor.authorViala, Vincent Louispt_BR
dc.contributor.authorLima, Loyze Paola Oliveira dept_BR
dc.contributor.authorMartins, Antonio Jorgept_BR
dc.contributor.authorBarros, Claudia Renata dos Santospt_BR
dc.contributor.authorMarqueze, Elaine Cristinapt_BR
dc.contributor.authorBernardino, Jardelina de Souza Todãopt_BR
dc.contributor.authorMoretti, Debora Botequiopt_BR
dc.contributor.authorMachado Neto, Raulpt_BR
dc.contributor.authorCovas, Dimas Tadeupt_BR
dc.contributor.authorSampaio, Sandra Coccuzzopt_BR
dc.contributor.authorElias, Maria Carolinapt_BR
dc.date.accessioned2021-12-13T18:35:02Z-
dc.date.available2021-12-13T18:35:02Z-
dc.date.issued2022pt_BR
dc.identifier.citationSlavov SN, Bezerra RS, Rodrigues ES, Santos EV, Lima ARJ, Viala VL, et al. Genomic monitoring of the SARS-CoV-2 B1.1.7 (WHO VOC Alpha) in the Sao Paulo state, Brazil. Virus Res. . doi:10.1016/j.virusres.2021.198643.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4026-
dc.description.abstractThe SARS-CoV-2 alpha VOC (also known as lineage B.1.1.7) initially described in the autumn, 2020 in UK, rapidly became the dominant lineage across much of Europe. Despite multiple studies reporting molecular evidence suggestive of its circulation in Brazil, much is still unknown about its genomic diversity in the state of São Paulo, the main Brazilian economic and transportation hub. To get more insight regarding its transmission dynamics into the State we performed phylogenetic analysis on all alpha VOC strains obtained between February and August 2021 from the Sao Paulo state Network for Pandemic Alert of Emerging SARS-CoV-2 variants. The performed phylogenetic analysis showed that most of the alpha VOC genomes were interspersed with viral strains sampled from different Brazilian states and other countries suggesting that multiple independent Alpha VOC introductions from Brazil and overseas have occurred in the São Paulo State over time. Nevertheless, large monophyletic clusters were also observed especially from the Central-West part of the São Paulo State (the city of Bauru) and the metropolitan region of the São Paulo city. Our results highlight the Alpha VOC molecular epidemiology in the São Paulo state and reinforce the need for continued genomic surveillance strategies for the real-time monitoring of potential emerging SARS-CoV-2 variants during the ever-growing vaccination process.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(FINEP) Financiadora de Estudos e Projetospt_BR
dc.description.sponsorshipHemocentro de Ribeirão Pretopt_BR
dc.description.sponsorship(OPAS) Pan American Health Organizationpt_BR
dc.format.extent198643pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofVirus Researchpt_BR
dc.rightsRestricted accesspt_BR
dc.titleGenomic monitoring of the SARS-CoV-2 B1.1.7 (WHO VOC Alpha) in the Sao Paulo state, Brazilpt_BR
dc.typeArticlept_BR
dc.identifier.doi10.1016/j.virusres.2021.198643pt_BR
dc.identifier.urlhttps://doi.org/10.1016/j.virusres.2021.198643pt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.externalNGS Soluções Genômicaspt_BR
dc.contributor.externalMendelics Análise Genômicapt_BR
dc.contributor.external(UNESP) Universidade Estadual Paulista Júlio de Mesquita Filhopt_BR
dc.contributor.external(FAMERP) Faculdade de Medicina de São José do Rio Pretopt_BR
dc.contributor.externalHospital das Clínicas de Botucatupt_BR
dc.contributor.external(UFMG) Universidade Federal de Minas Geraispt_BR
dc.contributor.external(ICC-FIOCRUZ) Instituto Carlos Chagaspt_BR
dc.identifier.citationvolume308pt_BR
dc.subject.keywordGenomic surveillancept_BR
dc.subject.keywordSARS-CoV-2pt_BR
dc.subject.keywordAlpha VOCpt_BR
dc.subject.keywordB.1.1.7pt_BR
dc.subject.keywordSão Paulopt_BR
dc.subject.keywordBrazilpt_BR
dc.relation.ispartofabbreviatedVirus Respt_BR
dc.identifier.citationabntv. 308, 198643, jan. 2022pt_BR
dc.identifier.citationvancouver2022 Jan; 308:198643pt_BR
dc.contributor.butantanSlavov, Svetoslav Nanev|:Outros|:Centro Bioindustrialpt_BR
dc.contributor.butantanPatané, José Salvatore Leister|:Desvinculado|:LCC - Laboratório de Ciclo Celularpt_BR
dc.contributor.butantanLima, Alex Ranieri Jeronimo|:Outros|:LCC - Laboratório de Ciclo Celularpt_BR
dc.contributor.butantanViala, Vincent Louis|:Técnico|:Lab. Bioquímicapt_BR
dc.contributor.butantanLima, Loyze Paola Oliveira de|:Técnico|:(LEDM) Lab. Estratégico de Diagnóstico Molecularpt_BR
dc.contributor.butantanMartins, Antonio Jorge|:Outros|:(HVB) Hospital Vital Brazilpt_BR
dc.contributor.butantanBarros, Claudia Renata dos Santos|:Outros|:Diretoria Técnicapt_BR
dc.contributor.butantanBernardino, Jardelina de Souza Todão|:Outros|:Centro Bioindustrialpt_BR
dc.contributor.butantanMoretti, Debora Botequio|:Outros|:Diretoria Técnicapt_BR
dc.contributor.butantanMachado Neto, Raul|:Outros|:Diretoria Técnicapt_BR
dc.contributor.butantanCovas, Dimas Tadeu|:Outros|:Diretoria Técnicapt_BR
dc.contributor.butantanSampaio, Sandra Coccuzzo|:Pesquisador:Docente Permanente PPGTox|:Lab. Fisiopatologiapt_BR
dc.contributor.butantanElias, Maria Carolina|:Pesquisador|:LCC - Laboratório de Ciclo Celularpt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/10127pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2020/05367–3pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2018/15826–5pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/08528–0pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/26950–6pt_BR
dc.sponsorship.butantanFinanciadora de Estudos e Projetos (FINEP)¦¦207.234pt_BR
dc.sponsorship.butantanHemocentro de Ribeirão Preto¦¦pt_BR
dc.sponsorship.butantan(OPAS) Pan American Health Organization¦¦pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
dc.description.internalPolítica de depósito: liberado apenas preprintpt_BR
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