Human immature dental pulp stem cells did not graft into a preexisting human lung Adenocarcinoma

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dc.contributor(LG) Laboratório de Genéticapt_BR
dc.contributor.authorSilva, Joyce Macedo dapt_BR
dc.contributor.authorAraldi, Rodrigo Pinheiropt_BR
dc.contributor.authorColozza-Gama, Gabriel Avelarpt_BR
dc.contributor.authorPagani, Eduardopt_BR
dc.contributor.authorSid, Ariyept_BR
dc.contributor.authorValverde, Cristiane Wenceslaupt_BR
dc.contributor.authorKerkis, Irinapt_BR
dc.identifier.citationSilva JM, Araldi RP, Colozza-Gama GA, Pagani E, Sid A, Valverde CW, et al. Human immature dental pulp stem cells did not graft into a preexisting human lung Adenocarcinoma. Case Rep. Oncol. 2022 Apr;15:413-422. doi:10.1159/issn.1662-6575.pt_BR
dc.description.abstractMesenchymal stem cell (MSC)-based therapies have been considered an attractive approach for treating Huntington’s disease (HD). However, due to the pulmonary first-passage effect associated with intravenous infusion (the most commonly used route of MSC administration), there is a rising concern that the cells could be entrapped in the lungs and grafted (homing) into preexisting lung cancer. Herein, we report the case of a patient with HD enrolled in a cell therapy phase I clinical trial for HD treatment having a preexisting pulmonary nodule. The nodule was found at the trial screening. The patient was referred to a pulmonologist who considered the nodule non-cancer and authorized enrollment. The patient received four intravenous administrations of human immature dental pulp stem cells (hIDPSCs) at the dose of 1 × 106 cells/kg of body weight within 2 years. One month after the last dose, a computerized tomography scan showed nodule growth. A bronchoscopy biopsy showed primary lung adenocarcinoma. The neoplasm was surgically excised (lung superior right lobectomy). The patient is cured of the neoplasm. The tumor was sectioned into six fragments, which were subjected to RNA-seq. The transcriptome of each tumor section was compared with the transcriptome of infused hIDPSCs using two statistical approaches: principal component analysis and NOIseq. Both results demonstrated a linear distance between the hIDPSCs and the lung adenocarcinoma. These results suggest that the infused hIDPSCs neither home nor graft within the pulmonary nodule.pt_BR
dc.relation.ispartofCase Reports in Oncologypt_BR
dc.rightsOpen accesspt_BR
dc.titleHuman immature dental pulp stem cells did not graft into a preexisting human lung Adenocarcinomapt_BR
dc.rights.licenseCC BY-NCpt_BR
dc.contributor.externalAzidus Brasilpt_BR
dc.contributor.externalCellavita Pesquisas Científicaspt_BR
dc.contributor.external(UNIFESP) Universidade Federal de São Paulopt_BR
dc.subject.keywordHuman immature dental pulp stem cellpt_BR
dc.subject.keywordHuntington’s diseasept_BR
dc.subject.keywordLung adenocarcinomapt_BR
dc.relation.ispartofabbreviatedCase Rep. Oncolpt_BR
dc.identifier.citationabntv. 15, p. 413-422, abr. 2022pt_BR
dc.identifier.citationvancouver2022 Apr;15:413-422pt_BR
dc.contributor.butantanAraldi, Rodrigo Pinheiro|:Desvinculado|(LG) Laboratório de Genética|:PrimeiroAutorpt_BR
dc.contributor.butantanKerkis, Irina|:Pesquisador:Docente Permanente PPGTox|:(LG) Laboratório de Genéticapt_BR
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