Snake venom matrix metalloproteinases (svMMPs)

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dc.contributor(LETA) Lab. Toxinologia Aplicadapt_BR
dc.contributor.authorJunqueira-de-Azevedo, Inácio de Loiola Meirellespt_BR
dc.contributor.authorBayona-Serrano, Juan Davidpt_BR
dc.date.accessioned2022-08-09T17:59:18Z-
dc.date.available2022-08-09T17:59:18Z-
dc.date.issued2021pt_BR
dc.identifier.isbn9780429054204pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4455-
dc.description.abstractThe ability to cause local tissue damage and hemorrhage is a commonly seen trait in many venoms from front-fanged snakes, and it is generally associated with snake venom metalloproteinases (SVMPs), one of the two types of well-characterized proteinases found in snake venoms. However, a new type of proteolytic enzyme with a completely different origin was shown to be a part of the venom arsenal of some rear-fanged snakes: snake venom matrix metalloproteinases (svMMPs). These enzymes are part of the matrix metalloproteinase (MMP) family of proteinases (also called matrixins), which is one of the four members of the metzincin superfamily of Zn2+ proteinases, together with astacins, serralysins and adamalysins – where traditional SVMPs belong. svMMPs have unique structural features among MMPs, making them a distinct type of metalloproteinase exclusively found in the venoms of some rear-fanged snake groups. In this chapter, we summarize how svMMPs were discovered, present the phylogenetic distribution of this component among rear-fanged snakes, and review the structural, evolutionary and functional information currently available for this new venom proteinase.pt_BR
dc.format.extent381-388pt_BR
dc.language.isoEnglishpt_BR
dc.publisherCRC Presspt_BR
dc.rightsRestricted accesspt_BR
dc.titleSnake venom matrix metalloproteinases (svMMPs)pt_BR
dc.typeBook chapterpt_BR
dc.description.version2pt_BR
dc.contributor.butantanJunqueira-de-Azevedo, Inácio de Loiola Meirelles|:Pesquisador|:pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.languageiso639-1English-
item.grantfulltextnone-
item.openairetypeBook chapter-
item.fulltextSem Texto completo-
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crisitem.author.orcid0000-0003-4491-0180-
crisitem.author.orcid#PLACEHOLDER_PARENT_METADATA_VALUE#-
crisitem.author.parentorg#PLACEHOLDER_PARENT_METADATA_VALUE#-
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