Caspase-1 and cathepsin B inhibitors from marine invertebrates, aiming at a reduction in neuroinflammation

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dc.contributor(LEDS) Lab. Dor e Sinalizaçãopt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorMoreno, Rafaela Indaleciopt_BR
dc.contributor.authorZambelli, Vanessa Olzonpt_BR
dc.contributor.authorPicolo, Giselept_BR
dc.contributor.authorCury, Yarapt_BR
dc.contributor.authorMorandini, André C.pt_BR
dc.contributor.authorMarques, Antonio Carlospt_BR
dc.contributor.authorSciani, Juliana Mozerpt_BR
dc.date.accessioned2022-11-08T13:20:11Z-
dc.date.available2022-11-08T13:20:11Z-
dc.date.issued2022pt_BR
dc.identifier.citationRIM, VO.Z, Picolo G, Cury Y, AC.M, ACM, et al. Caspase-1 and cathepsin B inhibitors from marine invertebrates, aiming at a reduction in neuroinflammation. Mar Drugs. 2022 Sep; 20(10):614. doi:10.3390/md20100614.pt_BR
dc.identifier.urihttps://repositorio.butantan.gov.br/handle/butantan/4678-
dc.description.abstractNeuroinflammation is a condition associated with several types of dementia, such as Alzheimer’s disease (AD), mainly caused by an inflammatory response to amyloid peptides that induce microglial activation, with subsequent cytokine release. Neuronal caspase-1 from inflammasome and cathepsin B are key enzymes mediating neuroinflammation in AD, therefore, revealing new molecules to modulate these enzymes may be an interesting approach to treat eurodegenerative diseases. In this study, we searched for new caspase-1 and cathepsin B inhibitors from five species of Brazilian marine invertebrates (four cnidarians and one echinoderm). The results show that the extract of the box jellyfish Chiropsalmus quadrumanus inhibits caspase-1. This extract was fractionated, and the products monitored for their inhibitory activity, until the obtention of a pure molecule, which was identified as trigonelline by mass spectrometry. Moreover, four extracts inhibit cathepsin B, and Exaiptasia diaphana was selected for subsequent fractionation and characterization, resulting in the identification of betaine as being responsible for the inhibitory action. Both molecules are already found in marine organisms, however, this is the first study showing a potent inhibitory effect on caspase-1 and cathepsin B activities. Therefore, these new prototypes can be considered for the enzyme inhibition and subsequent control of the neuroinflammation.pt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.description.sponsorship(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.extent614pt_BR
dc.language.isoEnglishpt_BR
dc.relation.ispartofMarine Drugspt_BR
dc.rightsOpen accesspt_BR
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/pt_BR
dc.titleCaspase-1 and cathepsin B inhibitors from marine invertebrates, aiming at a reduction in neuroinflammationpt_BR
dc.typeArticlept_BR
dc.rights.licenseCC BYpt_BR
dc.identifier.doi10.3390/md20100614pt_BR
dc.contributor.external(USF) Universidade São Franciscopt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(UNIFAG) Unidade Integrada de Farmacologia e Gastroenterologiapt_BR
dc.identifier.citationvolume20pt_BR
dc.identifier.citationissue10pt_BR
dc.subject.keywordcaspase-1pt_BR
dc.subject.keywordcathepsin Bpt_BR
dc.subject.keywordinhibitorpt_BR
dc.subject.keywordCnidariapt_BR
dc.subject.keywordEchinodermatapt_BR
dc.subject.keywordneuroinflammationpt_BR
dc.subject.keywordtrigonellinept_BR
dc.subject.keywordbetainept_BR
dc.relation.ispartofabbreviatedMar Drugspt_BR
dc.identifier.citationabntv. 20, 10, 614, set. 2022pt_BR
dc.identifier.citationvancouver2022 Sep; 20(10):614pt_BR
dc.contributor.butantanPicolo, Gisele|:Pesquisador|:(LEDS) Lab. Dor e Sinalizaçãopt_BR
dc.contributor.butantanCury, Yara|:Pesquisador|:(LEDS) Lab. Dor e Sinalizaçãopt_BR
dc.contributor.butantanSciani, Juliana Mozer|:Desvinculado|:(LEDS) Lab. Dor e Sinalizaçãopt_BR
dc.contributor.butantanZambelli, Vanessa Olzon|:Pesquisador|:Docente PPGTOX|:(LEDS) Lab. Dor e Sinalização|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2019/19929-6pt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2013/07467-1pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦316095/2021-4pt_BR
dc.sponsorship.butantan(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico¦¦309440/2019-0pt_BR
dc.identifier.bvsccBR78.1pt_BR
dc.identifier.bvsdbIBProdpt_BR
dc.description.dbindexedYespt_BR
item.openairetypeArticle-
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item.languageiso639-1English-
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