Rabies virus isolated from insectivorous bats induces different inflammatory responses in experimental model


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Article
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English
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Abstract
Rabies virus (RABV) is a neurotropic virus that causes fatal neuroinflammation in mammals. The insectivorous bat RABV strains are less pathogenic for mice than strains associated with other reservoirs. We characterized the tissue inflammatory response in the CNS of RABV isolated from insectivorous bats. Eptesicus furinalis (EPBRV)-infected mice had a robust inflammatory response and a greater amount of IL-1β, IL-6 and TNF-α, while Myotis nigricans (MNBRV)-infected mice showed a higher expression of IL-17 and greater activation of IFN-β. New approaches to understand the inflammatory response to different mechanisms of action may provide insights for the development of novel therapies for rabies.
Reference
Motta GH, Guimarães LP, Fernandes ER, Guedes F, Marques de Sá LR, Silva SR, et al. Rabies virus isolated from insectivorous bats induces different inflammatory responses in experimental model. J of Neuroim. 2022 Oct; 373:577974. doi:10.1016/j.jneuroim.2022.577974.
Link to cite this reference
https://repositorio.butantan.gov.br/handle/butantan/4694
URL
https://doi.org/10.1016/j.jneuroim.2022.577974
Issue Date
2022


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