The immunomodulatory potential role of mesenchymal stem cells in diseases of the central nervous system

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dc.contributor(LG) Lab. Genéticapt_BR
dc.contributorPrograma de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.authorRufino, Rodrigo de Andradept_BR
dc.contributor.authorPereira-Rufino, Laís da Silvapt_BR
dc.contributor.authorVissoto, Thays Cristina Silvapt_BR
dc.contributor.authorKerkis, Irinapt_BR
dc.contributor.authorCosta-Neves, Adrianapt_BR
dc.contributor.authorSilva, Marcelo Cavenaghi Pereira dapt_BR
dc.identifier.citationRufino RA, Pereira-Rufino LS, Vissoto TCS, Kerkis I, Costa-Neves A, Silva MCP. The immunomodulatory potential role of mesenchymal stem cells in diseases of the central nervous system. Neurodegener Dis. 2022 Nov; 22:68-82. doi:10.1159/000528036.pt_BR
dc.description.abstractSeveral studies indicate the role of mesenchymal stem cells (MSCs) as an important tool in regenerative medicine associated with injuries that affect the central nervous system (CNS). The MSCs have the capacity to differentiate into cells of the embryonal tissue, such as the mesoderm. So, these cells can be found in a variety of tissues. Also, the MSCs can release immunomodulatory and neurotrophic factors performance as inflammation mediators operating in injured tissue the regeneration. Furthermore, they can differentiate into neural, like cells in vitro. Thereby, because of the high immunomodulatory role of MSCs, this review sought to describe the main immunomodulatory mechanisms performed by MSCs in CNS recovery after tissue injury or neurodegenerative diseases. Methods: PubMed and ScienceDirect were searched between January 2011 to March 2021 and 43 articles met the criteria of the review. Results: This systematic review indicate that MSCs were used in vivo experimental Multiple Sclerosis (MS), Parkinson's disease (PA), Alzheimer's disease (AD), Amyotrophic Lateral Sclerosis (ALS), Ischemic Stroke (IS) and Traumatic Brain Injury (TBI). The treatment MSCs were usually from human origin, derived from bone marrow and administered intravenously. Discussion/Conclusion: It was shown that MSCs, independent from origin or administration pathway, can reduce inflammation and help in the recovery and preservation of injured neural tissue. Thus, the use of MSCs represents a potential therapeutic option in the treatment of neurological disorders mediated by inflammatory processes.pt_BR
dc.relation.ispartofNeurodegenerative Diseasespt_BR
dc.rightsOpen accesspt_BR
dc.titleThe immunomodulatory potential role of mesenchymal stem cells in diseases of the central nervous systempt_BR
dc.rights.licenseCC BYpt_BR
dc.contributor.external(UNIFESP) Universidade Federal de São Paulopt_BR
dc.subject.keywordmesenchymal stem cellspt_BR
dc.subject.keywordmedicinal signaling cellspt_BR
dc.subject.keywordcentral nervous systempt_BR
dc.subject.keywordneurodegenerative diseasespt_BR
dc.relation.ispartofabbreviatedNeurodegener Dispt_BR
dc.identifier.citationabntv. 22, 68-82, nov. 2022pt_BR
dc.identifier.citationvancouver2022 Nov; 22:68-82pt_BR
dc.contributor.butantanKerkis, Irina|:Pesquisador|:Docente PPGTOX|:(LG) Lab. Genética|:Programa de Pós-Graduação em Ciências – Toxinologia (PPGTox)pt_BR
dc.contributor.butantanCosta-Neves, Adriana|:Pesquisador|:(LG) Lab. Genéticapt_BR
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