Global SARS-CoV-2 genomic surveillance: what we have learned (so far)

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dc.contributor(LCC) Lab. Ciclo Celularpt_BR
dc.contributorGestão Científica dos Laboratóriospt_BR
dc.contributor(NUTERA-RP) Núcleo de Terapia Celular Avançadapt_BR
dc.contributor.authorTosta, Stephanept_BR
dc.contributor.authorMoreno, Keldennpt_BR
dc.contributor.authorSchuab, Gabrielpt_BR
dc.contributor.authorElias, Maria Carolinapt_BR
dc.contributor.authorSampaio, Sandra Coccuzzopt_BR
dc.contributor.authorSlavov, Svetoslav Nanevpt_BR
dc.identifier.citationTosta S, Moreno K, Schuab G, Fonseca V, Segovia FMC, Kashima S, et al. Global SARS-CoV-2 genomic surveillance: what we have learned (so far). Infect Genet Evol. 2023 Jan; 108:105405. doi:10.1016/j.meegid.2023.105405.pt_BR
dc.description.abstractThe COVID-19 pandemic has brought significant challenges for genomic surveillance strategies in public health systems worldwide. During the past thirty-four months, many countries faced several epidemic waves of SARS-CoV-2 infections, driven mainly by the emergence and spread of novel variants. In that line, genomic surveillance has been a crucial toolkit to study the real-time SARS-CoV-2 evolution, for the assessment and optimization of novel diagnostic assays, and to improve the efficacy of existing vaccines. During the pandemic, the identification of emerging lineages carrying lineage-specific mutations (particularly those in the Receptor Binding domain) showed how these mutations might significantly impact viral transmissibility, protection from reinfection and vaccination. So far, an unprecedented number of SARS-CoV-2 viral genomes has been released in public databases (i.e., GISAID, and NCBI), achieving 14 million genome sequences available as of early-November 2022. In the present review, we summarise the global landscape of SARS-CoV-2 during the first thirty-four months of viral circulation and evolution. It demonstrates the urgency and importance of sustained investment in genomic surveillance strategies to timely identify the emergence of any potential viral pathogen or associated variants, which in turn is key to epidemic and pandemic preparedness.pt_BR
dc.description.sponsorship(EC) European Commissionpt_BR
dc.description.sponsorship(ICGEB) International Centre for Genetic Engineering and Biotechnologypt_BR
dc.description.sponsorship(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.relation.ispartofInfection, Genetics and Evolutionpt_BR
dc.rightsOpen accesspt_BR
dc.titleGlobal SARS-CoV-2 genomic surveillance: what we have learned (so far)pt_BR
dc.rights.licenseCC BY-NC-NDpt_BR
dc.contributor.external(UFMG) Universidade Federal de Minas Geraispt_BR
dc.contributor.external(IOC) Instituto Oswaldo Cruzpt_BR
dc.contributor.external(UFRJ) Universidade Federal do Rio de Janeiropt_BR
dc.contributor.external(OPAS) Organização Pan-Americana da Saúdept_BR
dc.contributor.externalUniversidad Nacional de Asuncíonpt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.externalUniversity of Campus Bio-Medico di Romapt_BR
dc.subject.keywordviral evolutionpt_BR
dc.subject.keywordgenomic surveillancept_BR
dc.subject.keywordepidemic-pandemic preparednesspt_BR
dc.relation.ispartofabbreviatedInfect Genet Evolpt_BR
dc.identifier.citationabntv. 108, 105405, jan. 2023pt_BR
dc.identifier.citationvancouver2023 Jan; 108:105405pt_BR
dc.contributor.butantanElias, Maria Carolina|:Pesquisador|:(LCC) Lab. Ciclo Celular|:pt_BR
dc.contributor.butantanSampaio, Sandra Coccuzzo|:Pesquisador|:Gestão Científica dos Laboratórios|:pt_BR
dc.contributor.butantanSlavov, Svetoslav Nanev|:Pesquisador|:(NUTERA-RP) Núcleo de Terapia Celular Avançadapt_BR
dc.sponsorship.butantan(FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo¦¦2017/23205-8pt_BR
dc.sponsorship.butantan(EC) European Commission¦¦Ricerca e Innovazione¦¦2014-2020pt_BR
dc.sponsorship.butantan(ICGEB) International Centre for Genetic Engineering and Biotechnology¦¦CRP/BRA20-03pt_BR
dc.sponsorship.butantan(ICGEB) International Centre for Genetic Engineering and Biotechnology¦¦CRP/20/03pt_BR
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