Retrospective spatio-temporal dynamics of dengue virus 1, 2 and 4 in Paraguay

Publication type
Access rights
Open access
Terms of use
Appears in Collections:
Dengue virus (DENV) has been a major public health concern in Paraguay, with frequent outbreaks occurring since early 1988. Although control measures have been implemented, dengue remains a significant health threat in the country, and continued efforts are required for prevention and control. In response to that, in collaboration with the Central Public Health Laboratory in Asunción, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate DENV viral strains circulating in Paraguay over the past epidemics. Our genomic surveillance activities revealed the co-circulation of multiple DENV serotypes: DENV-1 genotype V, the emerging DENV-2 genotype III, BR4-L2 clade, and DENV-4 genotype II. Results additionally highlight the possible role of Brazil as a source for the international dispersion of different viral strains to other countries in the Americas emphasizing the need for increased surveillance across the borders, for the early detection and response to outbreaks. This, in turn, emphasizes the critical role of genomic surveillance in monitoring and understanding arbovirus transmission and persistence locally and over long distances.
Vazquez C, Alcantara LCJ, Fonseca V, Lima ARJ, Elias MC, Sampaio SC. Retrospective spatio-temporal dynamics of dengue virus 1, 2 and 4 in Paraguay. Viruses. 2023 May; 15(6):1275. doi:10.3390/v15061275.
Link to cite this reference
Journal title
Issue Date

Files in This Item:

Show full item record

This item is licensed under a Creative Commons License Creative Commons