Acanthoscurria gomesiana spider-derived Mygalin in the prelimbic prefrontal cortex modulates neuropathic pain and depression comorbid

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dc.contributor(CeTICS) Centro de Toxinas, Resposta-imune e Sinalização Celularpt_BR
dc.contributor(CEPID) Centro de Pesquisa, Inovação e Difusãopt_BR
dc.contributor(LETA) Lab. Toxinologia Aplicadapt_BR
dc.contributor.authorMedeiros, Ana Carolinapt_BR
dc.contributor.authorMedeiros, Priscilapt_BR
dc.contributor.authorRuggiero, Rafael Naimept_BR
dc.contributor.authorGregorio, Danilo dept_BR
dc.contributor.authorGobbi, Gabriellapt_BR
dc.contributor.authorSilva Junior, Pedro Ismael dapt_BR
dc.contributor.authorSantos, Wagner Ferreira dospt_BR
dc.contributor.authorCoimbra, Norberto Cysnept_BR
dc.contributor.authorFreitas, Renato Leonardo dept_BR
dc.identifier.citationMedeiros AC, Medeiros P, Ruggiero RN, Gregorio D, Gobbi G, Silva Junior PI, et al. Acanthoscurria gomesiana spider-derived Mygalin in the prelimbic prefrontal cortex modulates neuropathic pain and depression comorbid. J Biochem Mol Toxicol. 2023 Jul; 37(7):e23353. doi:10.1002/jbt.23353.pt_BR
dc.description.abstractDepression has a high rate of comorbidity with neuropathic pain. This study aims to investigate the effect of Mygalin, an acylpolyamine synthesized from a natural molecule in the hemolymph of the Acanthoscurria gomesiana spider, injected into the prelimbic (PrL) region of the medial prefrontal cortex on chronic neuropathic pain and depression comorbidity in rats. To investigate that comorbidity, neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve in male Wistar rats. The biotinylated biodextran amine (BDA) bidirectional neural tract tracer was microinjected into the PrL cortex to study brain connections. Rodents were further subjected to von Frey (mechanical allodynia), acetone (cold allodynia), and forced swim (depressive-like behavior) tests. BDA neural tract tracer-labeled perikarya were found in the dorsal columns of the periaqueductal gray matter (dPAG) and the dorsal raphe nucleus (DRN). Neuronal activity of DRN neurons decreased in CCI rats. However, PrL cortex treatment with Mygalin increased the number of spikes on DRN neurons. Mygalin treatment in the PrL cortex decreased both mechanical and cold allodynia and immobility behavior in CCI rats. PrL cortex treatment with N-methyl-D-aspartate (NMDA) receptor receptors attenuated the analgesic and antidepressive effects caused by Mygalin. The PrL cortex is connected with the dPAG and DRN, and Mygalin administration into the PrL increased the activity of DRN neurons. Mygalin in the PrL cortex produced antinociceptive and antidepressive-like effects, and the NMDA agonist reversed these effects.pt_BR
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologypt_BR
dc.rightsRestricted accesspt_BR
dc.titleAcanthoscurria gomesiana spider-derived Mygalin in the prelimbic prefrontal cortex modulates neuropathic pain and depression comorbidpt_BR
dc.contributor.external(USP) Universidade de São Paulopt_BR
dc.contributor.external(UFSCar) Universidade Federal de São Carlospt_BR
dc.contributor.externalMcGill Universitypt_BR
dc.relation.ispartofabbreviatedJ Biochem Mol Toxicolpt_BR
dc.identifier.citationabntv. 37, n. 7, e23353, jul. 2023pt_BR
dc.identifier.citationvancouver2023 Jul; 37(7):e23353pt_BR
dc.contributor.butantanSilva Junior, Pedro Ismael da|:Pesquisador|:(LETA) Lab. Toxinologia Aplicada|:(CeTICS) Centro de Toxinas, Resposta-imune e Sinalização Celular|:(CEPID) Centro de Pesquisa, Inovação e Difusãopt_BR
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