Influência do ciclo claro e escuro na recuperação da anestesia com cetamina e xilazina em camundongos

Abstract

In recent years, there has been an increasing interest in understanding the biological rhythm's influences on physiological, pathological, and therapeutic processes. As a result of the intimate relationship with the physiological processes, the drug's pharmacological and toxicological parameters can be affected by the circadian variation in organ activity. This research was a crossover interventional study to evaluate whether the light and dark cycle impacts the recovery from ketamine and xylazine anesthesia. The studied sample consisted of two groups of mice. One group underwent intervention in the light phase and the other in the dark phase. After a week, a crossover method application according to the light and dark cycle period. Indeed, the light and dark cycle impacted recovery from ketamine and xylazine anesthesia in mice.In the present study, the mice anesthetized in the dark (2.35h) recovered postural straightening significantly faster than mice anesthetized in the light (3.40h p<0.001), and this effect is independent of the sex of the animal.